Skip to main content
Top
Published in: European Journal of Pediatrics 12/2003

01-12-2003 | Original Paper

Type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria

Authors: Birgit Rami, Edith Schober, Edith Nachbauer, Thomas Waldhör, Austrian Diabetes Incidence Study Group

Published in: European Journal of Pediatrics | Issue 12/2003

Login to get access

Abstract

Until recently, most children with diabetes mellitus had type 1 diabetes (T1DM). The prevalence of type 2 diabetes (T2DM) is on the rise in North America, especially in risk populations such as the American Indians. Few epidemiological data on the incidence of the disease exist in Europe. In a prospective population-based epidemiological study, all newly diagnosed cases of diabetes mellitus in patients under 15 years of age were registered nation-wide in Austria between 1999 and 2001. Differential diagnosis (according to the American Diabetes Association diagnostic criteria) was based on clinical case definition. During the 3 years of the study period, 529 cases of DM <15 years were documented, of which 510 were clinically assigned to T1DM (271 boys, 239 girls) resulting in an incidence rate of 12.4/100,000. In the same network, eight cases were diagnosed as T2DM (one boy, seven girls) and two cases with an atypical form of T2DM (two girls). The age of onset of T2DM was 12–15 years and all patients were overweight (body mass index >90th percentile).The calculated incidence for T2DM <15 years in Austria was 0.25/100,000. Conclusion: at present, type 2 diabetes mellitus is rare but exists in children aged under 15 years in Austria. Follow-up of this registration will help to describe the secular trend.
Literature
1.
go back to reference American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Pediatrics 105: 671–680PubMed American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Pediatrics 105: 671–680PubMed
2.
go back to reference Barrett TG, Ethisham S, Smith A, Hattersley AT (2002) UK Diabetes Survey shows type 2 diabetes present in 0.4% of newly diagnosed children, associated with overweight, female and ethnic minority status. Diabetes 51[Suppl]: A25 Barrett TG, Ethisham S, Smith A, Hattersley AT (2002) UK Diabetes Survey shows type 2 diabetes present in 0.4% of newly diagnosed children, associated with overweight, female and ethnic minority status. Diabetes 51[Suppl]: A25
3.
go back to reference Drake AJ, Smith A, Betts PR, Crowne EC, Shield JPH (2002) Type 2 diabetes in obese white children. Arch Dis Child 86: 207–208CrossRefPubMed Drake AJ, Smith A, Betts PR, Crowne EC, Shield JPH (2002) Type 2 diabetes in obese white children. Arch Dis Child 86: 207–208CrossRefPubMed
4.
go back to reference Ethisham S, Barrett TG, Shaw NJ (2000) Type 2 diabetes mellitus in UK children – an emerging problem. Diabetes Med 17: 867–871CrossRef Ethisham S, Barrett TG, Shaw NJ (2000) Type 2 diabetes mellitus in UK children – an emerging problem. Diabetes Med 17: 867–871CrossRef
5.
go back to reference EURODIAB ACE Study Group (2000) Variation and trends in incidence of childhood diabetes in Europe. Lancet 355: 873–876PubMed EURODIAB ACE Study Group (2000) Variation and trends in incidence of childhood diabetes in Europe. Lancet 355: 873–876PubMed
6.
go back to reference Fagot-Campagna A, Pettitt DJ, Engelau MM, Burrows NR, Geiss LS, Valdez R, Beckles GLA, Saaddine J, Gregg EW, Williamson DF, Narayan KMV (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136: 664–672CrossRefPubMed Fagot-Campagna A, Pettitt DJ, Engelau MM, Burrows NR, Geiss LS, Valdez R, Beckles GLA, Saaddine J, Gregg EW, Williamson DF, Narayan KMV (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136: 664–672CrossRefPubMed
7.
go back to reference Fagot-Campagna A, Saadine JB, Flegal KM, Beckles GLA (2001) Diabetes, impaired fasting glucose, and elevated HbA1c in U.S. adolescents: The Third National Health and Nutrition Examination Survey. Diabetes Care 24: 834–837PubMed Fagot-Campagna A, Saadine JB, Flegal KM, Beckles GLA (2001) Diabetes, impaired fasting glucose, and elevated HbA1c in U.S. adolescents: The Third National Health and Nutrition Examination Survey. Diabetes Care 24: 834–837PubMed
8.
go back to reference Kadiki OA, Reddy MR, Marzouk AA (1996) Incidence of insulin dependent and non-insulin dependent (0–34 years at onset) in Benghazi, Libya. Diabetes Res Clin Pract 32: 165–173CrossRefPubMed Kadiki OA, Reddy MR, Marzouk AA (1996) Incidence of insulin dependent and non-insulin dependent (0–34 years at onset) in Benghazi, Libya. Diabetes Res Clin Pract 32: 165–173CrossRefPubMed
9.
go back to reference Kitagawa T, Owada M, Urakami T, Yamuchi K (1998) Increased incidence of non-insulin dependent diabetes mellitus among Japanese school children correlates with an increased intake of animal protein and fat. Clin Pediatr 37: 111–116 Kitagawa T, Owada M, Urakami T, Yamuchi K (1998) Increased incidence of non-insulin dependent diabetes mellitus among Japanese school children correlates with an increased intake of animal protein and fat. Clin Pediatr 37: 111–116
10.
go back to reference Körner A, Madácsy L, Tulassay T (2000) Increasing prevalence of type 2 diabetes mellitus in children and adolescents in Hungary. Abstract IDF, Mexico Körner A, Madácsy L, Tulassay T (2000) Increasing prevalence of type 2 diabetes mellitus in children and adolescents in Hungary. Abstract IDF, Mexico
11.
go back to reference Kromeyer-Hauschild K, Wabitsch M, Kunze D, Geller F, Geiß HC, Hesse V, von Hippel A, Jaeger U, Johnson D, Korte W, Menner K, Müller G, Müller JM, Niemann-Pilatus A, Remer T, Schaefer F, Wittchen HU, Zabransky S, Zellner K, Ziegler A, Hebebrand J (2001) Perzentile für den Body-mass-Index für das Kindes-und-Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilk 149: 807–818CrossRef Kromeyer-Hauschild K, Wabitsch M, Kunze D, Geller F, Geiß HC, Hesse V, von Hippel A, Jaeger U, Johnson D, Korte W, Menner K, Müller G, Müller JM, Niemann-Pilatus A, Remer T, Schaefer F, Wittchen HU, Zabransky S, Zellner K, Ziegler A, Hebebrand J (2001) Perzentile für den Body-mass-Index für das Kindes-und-Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilk 149: 807–818CrossRef
12.
go back to reference Neufeld ND, Raffel LJ, Landon C, Chen YDI, Vadheim CM (1998) Early presentation of type 2 diabetes in Mexican-American youth. Diabetes Care 21: 80–86PubMed Neufeld ND, Raffel LJ, Landon C, Chen YDI, Vadheim CM (1998) Early presentation of type 2 diabetes in Mexican-American youth. Diabetes Care 21: 80–86PubMed
13.
go back to reference Ortega-Rodriguez E, Levy-Marchal C, Tubiana N, Czernikow P, Polak M (2001) Emergence of type 2 diabetes in a hospital based cohort of children with diabetes mellitus. Diabetes Metab 27: 574–578PubMed Ortega-Rodriguez E, Levy-Marchal C, Tubiana N, Czernikow P, Polak M (2001) Emergence of type 2 diabetes in a hospital based cohort of children with diabetes mellitus. Diabetes Metab 27: 574–578PubMed
14.
go back to reference Pinhas-Hamiel O, Dolan LM, Daniels SR, Stanford D, Khoury PR, Zeitler P (1996) Increased incidence of non insulin dependent diabetes mellitus among adolescents. J Pediatr 128: 608–615PubMed Pinhas-Hamiel O, Dolan LM, Daniels SR, Stanford D, Khoury PR, Zeitler P (1996) Increased incidence of non insulin dependent diabetes mellitus among adolescents. J Pediatr 128: 608–615PubMed
15.
go back to reference Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22: 345–354PubMed Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22: 345–354PubMed
16.
go back to reference Schober E, Waldhör T, Kirchengast S, Sefranek R (2002) Prevalences of overweight and obesity in male adolescents in Austria. A population-based study. J Pediatr Endocrinol Metab 15[Suppl 4]: 1068 Schober E, Waldhör T, Kirchengast S, Sefranek R (2002) Prevalences of overweight and obesity in male adolescents in Austria. A population-based study. J Pediatr Endocrinol Metab 15[Suppl 4]: 1068
17.
go back to reference Scott CR, Smith JM, Cradock MM, Pithoker C (1997) Characteristics of youth-onset non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 100: 84–91PubMed Scott CR, Smith JM, Cradock MM, Pithoker C (1997) Characteristics of youth-onset non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 100: 84–91PubMed
18.
go back to reference Shinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346: 802–810 Shinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346: 802–810
19.
go back to reference The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 26[Suppl 1]: S5–S20 The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 26[Suppl 1]: S5–S20
20.
go back to reference Waldhör T, Schober E, Karimian-Theherani D, Rami B and the Austrian Diabetes Incidence Study Group (2000) Regional differences and temporal incidence trend of type 1 diabetes mellitus in Austria from 1989 to 1999: a nationwide study. Diabetologia 43: 1449–1450 Waldhör T, Schober E, Karimian-Theherani D, Rami B and the Austrian Diabetes Incidence Study Group (2000) Regional differences and temporal incidence trend of type 1 diabetes mellitus in Austria from 1989 to 1999: a nationwide study. Diabetologia 43: 1449–1450
21.
go back to reference Waldhör T, Schober E, Rami B and the Austrian Diabetes Incidence Study Group (2003) Regional distribution of risk for childhood diabetes in Austria and possible association with BMI. Eur J Pediatr 162: 380–384PubMed Waldhör T, Schober E, Rami B and the Austrian Diabetes Incidence Study Group (2003) Regional distribution of risk for childhood diabetes in Austria and possible association with BMI. Eur J Pediatr 162: 380–384PubMed
22.
go back to reference Wilkin TJ (2001) The accelerator hypothesis: weight gain as the missing link between type 1 and type 2 diabetes. Diabetologia 44: 914–922PubMed Wilkin TJ (2001) The accelerator hypothesis: weight gain as the missing link between type 1 and type 2 diabetes. Diabetologia 44: 914–922PubMed
23.
go back to reference Young TK, Dean HJ, Flett B, Wood-Steinman P (2000) Childhood obesity in a population at high risk for type 2 diabetes. J Pediatr 136: 365–369PubMed Young TK, Dean HJ, Flett B, Wood-Steinman P (2000) Childhood obesity in a population at high risk for type 2 diabetes. J Pediatr 136: 365–369PubMed
Metadata
Title
Type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria
Authors
Birgit Rami
Edith Schober
Edith Nachbauer
Thomas Waldhör
Austrian Diabetes Incidence Study Group
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 12/2003
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-003-1323-7

Other articles of this Issue 12/2003

European Journal of Pediatrics 12/2003 Go to the issue

Acknowledgement to our Reviewers

Acknowledgement to our Reviewers