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Medical Microbiology and Immunology
Published in: Medical Microbiology and Immunology 6/2017

Open Access 01-12-2017 | Review

Immune response against rickettsiae: lessons from murine infection models

Author: Anke Osterloh

Published in: Medical Microbiology and Immunology | Issue 6/2017

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Abstract

Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections.
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Metadata
Title
Immune response against rickettsiae: lessons from murine infection models
Author
Anke Osterloh
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Medical Microbiology and Immunology / Issue 6/2017
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-017-0514-1

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