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Published in: Medical Microbiology and Immunology 1/2014

01-02-2014 | Original Investigation

HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort

Authors: Syed Hani Abidi, Aniqa Shahid, Laila S. Lakhani, Reena Shah, Nancy Okinda, Peter Ojwang, Farhat Abbas, Sarah Rowland-Jones, Syed Ali

Published in: Medical Microbiology and Immunology | Issue 1/2014

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Abstract

In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient’s HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients’ viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection.
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Metadata
Title
HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort
Authors
Syed Hani Abidi
Aniqa Shahid
Laila S. Lakhani
Reena Shah
Nancy Okinda
Peter Ojwang
Farhat Abbas
Sarah Rowland-Jones
Syed Ali
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Medical Microbiology and Immunology / Issue 1/2014
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-013-0314-1

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