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01-03-2008 | Review

Heat shock proteins: linking danger and pathogen recognition

Authors: Anke Osterloh, Minka Breloer

Published in: Medical Microbiology and Immunology | Issue 1/2008

Abstract

Besides their central function in protein folding and transport within the cell, heat shock proteins (HSP) have been shown to modulate innate and adaptive immune response: (1) HSP mediate uptake and MHC presentation of HSP-associated peptides by antigen-presenting cells (APC). (2) HSP function as endogenous danger signals indicating cell stress and tissue damage to the immune system. (3) HSP bind pathogen-associated molecular pattern (PAMP) molecules and modulate PAMP-induced Toll-like receptor (TLR) signaling. Thus, HSP contribute to both, recognition of “danger” defined as uncontrolled tissue destruction and recognition of dangerous “nonself”. In this review these different aspects of immune stimulation by HSP will be discussed.

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Title: Heat shock proteins: linking danger and pathogen recognition
Authors: Anke Osterloh
Minka Breloer
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: Medical Microbiology and Immunology / Issue 1/2008
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-007-0055-0

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