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01-05-2019 | Original Article

Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses

Authors: Eunjin Hwang, Ritchie E. Brown, Bernat Kocsis, Tae Kim, James T. McKenna, James M. McNally, Hio-Been Han, Jee Hyun Choi

Published in: Brain Structure and Function | Issue 4/2019

Abstract

High-density electroencephalographic (hdEEG) recordings are widely used in human studies to determine spatio-temporal patterns of cortical electrical activity. How these patterns of activity are modulated by subcortical arousal systems is poorly understood. Here, we couple selective optogenetic stimulation of a defined subcortical cell-type, basal forebrain (BF) parvalbumin (PV) neurons, with hdEEG recordings in mice (Opto-hdEEG). Stimulation of BF PV projection neurons preferentially generated time-locked gamma oscillations in frontal cortices. BF PV gamma-frequency stimulation potently modulated an auditory sensory paradigm used to probe cortical function in neuropsychiatric disorders, the auditory steady-state response (ASSR). Phase-locked excitation of BF PV neurons in advance of 40 Hz auditory stimuli enhanced the power, precision and reliability of cortical responses, and the relationship between responses in frontal and auditory cortices. Furthermore, synchronization within a frontal hub and long-range cortical interactions were enhanced. Thus, phasic discharge of BF PV neurons changes cortical processing in a manner reminiscent of global workspace models of attention and consciousness.

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Title: Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses
Authors: Eunjin Hwang
Ritchie E. Brown
Bernat Kocsis
Tae Kim
James T. McKenna
James M. McNally
Hio-Been Han
Jee Hyun Choi
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 4/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01845-5

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Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses

Abstract

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Abstract

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