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Brain Structure and Function
Published in: Brain Structure and Function 5/2018

01-06-2018 | Original Article

Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity

Authors: Antonela Muca, Emily Standafer, Aaron K. Apawu, Farhan Ahmad, Farhad Ghoddoussi, Mirabela Hali, James Warila, Bruce A. Berkowitz, Avril Genene Holt

Published in: Brain Structure and Function | Issue 5/2018

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Abstract

Loud noise frequently results in hyperacusis or hearing loss (i.e., increased or decreased sensitivity to sound). These conditions are often accompanied by tinnitus (ringing in the ears) and changes in spontaneous neuronal activity (SNA). The ability to differentiate the contributions of hyperacusis and hearing loss to neural correlates of tinnitus has yet to be achieved. Towards this purpose, we used a combination of behavior, electrophysiology, and imaging tools to investigate two models of noise-induced tinnitus (either with temporary hearing loss or with permanent hearing loss). Manganese (Mn2+) uptake was used as a measure of calcium channel function and as an index of SNA. Manganese uptake was examined in vivo with manganese-enhanced magnetic resonance imaging (MEMRI) in key auditory brain regions implicated in tinnitus. Following acoustic trauma, MEMRI, the SNA index, showed evidence of spatially dependent rearrangement of Mn2+ uptake within specific brain nuclei (i.e., reorganization). Reorganization of Mn2+ uptake in the superior olivary complex and cochlear nucleus was dependent upon tinnitus status. However, reorganization of Mn2+ uptake in the inferior colliculus was dependent upon hearing sensitivity. Furthermore, following permanent hearing loss, reduced Mn2+ uptake was observed. Overall, by combining testing for hearing sensitivity, tinnitus, and SNA, our data move forward the possibility of discriminating the contributions of hyperacusis and hearing loss to tinnitus.
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Metadata
Title
Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity
Authors
Antonela Muca
Emily Standafer
Aaron K. Apawu
Farhan Ahmad
Farhad Ghoddoussi
Mirabela Hali
James Warila
Bruce A. Berkowitz
Avril Genene Holt
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 5/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-018-1635-z

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