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Open Access 01-06-2018 | Original Article

Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution

Authors: Fani Memi, Nada Zecevic, Nevena Radonjić

Published in: Brain Structure and Function | Issue 5/2018

Abstract

Sonic Hedgehog (Shh) plays an instrumental role in brain development, fine-tuning processes such as cell proliferation, patterning, and fate specification. Although, mutations in the SHH pathway in humans are associated with various neurodevelopmental disorders, ranging from holoprosencephaly to schizophrenia, its expression pattern in the developing human brain is not well established. We now determined the previously not reported wide expression of SHH in the human fetal cerebral cortex during most of the gestation period (10–40 gestational weeks). This spatiotemporal distribution puts Shh in a position to influence the fundamental processes involved in corticogenesis. SHH expression increased during development, shifting from progenitor cells in the proliferative zones to neurons, both glutamatergic and GABAergic, and astrocytes in upper cortical compartments. Importantly, the expression of its downstream effectors and complementary receptors revealed evolutionary differences in SHH-pathway gene expression between humans and rodents.

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Title: Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution
Authors: Fani Memi
Nada Zecevic
Nevena Radonjić
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 5/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-018-1621-5

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Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution

Abstract

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Abstract

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