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Open Access 01-01-2018 | Original Article

Cortical morphology of the pars opercularis and its relationship to motor-inhibitory performance in a longitudinal, developing cohort

Authors: Lauren B. Curley, Erik Newman, Wesley K. Thompson, Timothy T. Brown, Donald J. Hagler Jr., Natacha Akshoomoff, Chase Reuter, Anders M. Dale, Terry L. Jernigan

Published in: Brain Structure and Function | Issue 1/2018

Abstract

This study investigates the relationship between variability in cortical surface area and thickness of the pars opercularis of the inferior frontal gyrus and motor-inhibitory performance on a stop-signal task in a longitudinal, typically developing cohort of children and adolescents. Linear mixed-effects models were used to investigate the hypotheses that (1) cortical thinning and (2) a relatively larger cortical surface area of the bilateral pars opercularis of the inferior frontal gyrus would predict better performance on the stop-signal task in a cohort of 110 children and adolescents 4–13 years of age, with one to four observations (totaling 232 observations). Cortical thickness of the bilateral opercular region was not related to inhibitory performance. However, independent of age, gender, and total cortical surface area, relatively larger cortical surface area of the bilateral opercular region of the inferior frontal gyrus was associated with better motor-inhibitory performance. Follow-up analyses showed a significant effect of surface area of the right pars opercularis, but no evidence for an effect of area of left pars opercularis, on motor-inhibitory performance. These findings are consistent with the previous work in adults showing that cortical morphology of the pars opercularis is related to inhibitory functioning. It also expands upon this literature by showing that, in contrast to earlier work highlighting the importance of cortical thickness of this region in adults, relative cortical surface area of the pars opercularis may be related to developing motor-inhibitory functions during childhood and adolescence. Relationships between cortical phenotypes and individual differences in behavioral measures may vary across the lifespan.

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Title: Cortical morphology of the pars opercularis and its relationship to motor-inhibitory performance in a longitudinal, developing cohort
Authors: Lauren B. Curley
Erik Newman
Wesley K. Thompson
Timothy T. Brown
Donald J. Hagler Jr.
Natacha Akshoomoff
Chase Reuter
Anders M. Dale
Terry L. Jernigan
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1480-5

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Cortical morphology of the pars opercularis and its relationship to motor-inhibitory performance in a longitudinal, developing cohort

Abstract

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Abstract

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