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Brain Structure and Function
Published in: Brain Structure and Function 4/2016

01-05-2016 | Short Communication

Ryanodine-mediated conversion of STP to LTP is lacking in synaptopodin-deficient mice

Authors: Gayane Grigoryan, Menahem Segal

Published in: Brain Structure and Function | Issue 4/2016

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Abstract

In previous studies we and others have found that activation of ryanodine receptors (RyRs) facilitate expression of long-term potentiation (LTP) of reactivity to afferent stimulation in hippocampal slices, with a more pronounced action in the ventral hippocampus. We have also been able to link the involvement of synaptopodin (SP), an actin-binding protein, with neuronal plasticity via its interaction with RyRs. To test this link more directly, we have now compared the ability of ryanodine to convert short-term to LTP in hippocampal slices taken from normal and SP-knockout (SPKO) mice. Indeed, SPKO hippocampus expresses lower concentrations of RyRs and in slices of these mice ryanodine is unable to facilitate conversion of short-term to LTP. These observations link functionally SP with calcium stores.
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Metadata
Title
Ryanodine-mediated conversion of STP to LTP is lacking in synaptopodin-deficient mice
Authors
Gayane Grigoryan
Menahem Segal
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 4/2016
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-015-1026-7

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