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Open Access 01-01-2015 | Original Article

Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography

Authors: Michael Dayan, Monica Munoz, Sebastian Jentschke, Martin J. Chadwick, Janine M. Cooper, Kate Riney, Faraneh Vargha-Khadem, Chris A. Clark

Published in: Brain Structure and Function | Issue 1/2015

Abstract

The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5–18 years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

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Title: Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography
Authors: Michael Dayan
Monica Munoz
Sebastian Jentschke
Martin J. Chadwick
Janine M. Cooper
Kate Riney
Faraneh Vargha-Khadem
Chris A. Clark
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0655-y

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Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography

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