Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Neuroradiology
Published in: Neuroradiology 4/2004

01-04-2004 | Paediatric Neuroradiology

Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence

Authors: J. F. L. Schneider, K. A. Il’yasov, J. Hennig, E. Martin

Published in: Neuroradiology | Issue 4/2004

Login to get access

Abstract

We investigated the isotropic diffusion coefficient (D’) and fractional anisotropy (FA) in white matter (WM) during brain development, using an optimised diffusion-tensor imaging (DTI) method with whole brain coverage in a clinically acceptable time. We images 52 children with no evident neurological abnormality (30 boys, 22 girls aged 1 day–16 years) using high-angle DTI with optimised temporal gradient performance. D’ and FA were calculated in 10 regions of interest in white matter. We saw that the age-related reduction in D’ and increase in FA follow a mono- or biexponential model in white matter, probably depending on the compactness and myelination rate of the fibre tracts. In contrast to other areas, in which adult values were reached during the third year, there is a trend to continuous increase in FA in all deep white-matter areas, suggesting continuing maturation and organisation of deep tracts not detected on conventional MRI.
Literature
1.
Basser PJ, Mattiello J, LeBihan D (1994) MR diffusion tensor spectroscopy and imaging. Biophys J 66: 259–267PubMed
2.
Mori S, van Zijl PC (1995) Diffusion weighting by the trace of the diffusion tensor within a single scan. Magn Reson Med 33: 41–52PubMed
3.
Baratti C, Barnett AS, Pierpaoli C (1999) Comparative MR imaging study of brain maturation in kittens with T1, T2, and the trace of the diffusion tensor. Radiology 210: 133–142PubMed
4.
Huppi PS, Maier SE, Peled S, et al (1998) Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res 44: 584–590PubMed
5.
Klingberg T, Vaidya CJ, Gabrieli JD, et al (1999) Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport 10: 2817–2821PubMed
6.
Pierpaoli C, Basser PJ (1996) Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36: 893–906PubMed
7.
Pierpaoli C, Jezzard P, Basser PJ, et al (1996) Diffusion tensor MR imaging of the human brain. Radiology 201: 637–648PubMed
8.
Nomura Y, Sakuma H, Takeda K, et al (1994) Diffusional anisotropy of the human brain assessed with diffusion-weighted MR: relation with normal brain development and aging. AJNR 15: 231–238
9.
Morriss MC, Zimmerman RA, Bilaniuk LT, et al (1999) Changes in brain water diffusion during childhood. Neuroradiology 41: 929–934CrossRefPubMed
10.
Prayer D, Barkovich AJ, Kirschner DA, et al (2001) Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy. AJNR 22: 1572–1576
11.
Wimberger DM, Roberts TP, Barkovich AJ, et al (1995) Identification of “premyelination” by diffusion-weighted MRI. J Comput Assist Tomogr 19: 28–33PubMed
12.
Barkovich AJ (2000) Concepts of myelin and myelination in neuroradiology. AJNR 21: 1099–1109
13.
Neil JJ, Shiran SI, McKinstry RC, et al (1998) Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 209: 57–66PubMed
14.
Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111: 209–219PubMed
15.
Conturo TE, Lori NF, Cull TS, et al (1999) Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci USA 96: 10422–10427CrossRefPubMed
16.
Basser PJ, Pajevic S, Pierpaoli C, et al (2000) In vivo fiber tractography using DT-MRI data. Magn Reson Med 44: 625–632CrossRefPubMed
17.
Jones DK, Horsfield MA, Simmons A (1999) Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 42: 515–525CrossRefPubMed
18.
Bastin ME, Armitage PA (2000) On the use of water phantom images to calibrate and correct eddy current induced artefacts in MR diffusion tensor imaging. Magn Reson Imaging 18: 681–687CrossRefPubMed
19.
Simpson JH CH (1958) Diffusion and nuclear spin relaxation in water. Phys Rev 111: 1201–1202CrossRef
20.
Mukherjee P, Miller JH, Shimony JS, et al (2001) Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology 221: 349–358PubMed
21.
Jezzard P, Barnett AS, Pierpaoli C (1998) Characterization of and correction for eddy current artifacts in echo planar diffusion imaging. Magn Reson Med 39: 801–812PubMed
22.
Haselgrove JC, Moore JR (1996) Correction for distortion of echo-planar images used to calculate the apparent diffusion coefficient. Magn Reson Med 36: 960–964PubMed
23.
Papadakis NG, Xing D, Houston GC, et al (1999) A study of rotationally invariant and symmetric indices of diffusion anisotropy. Magn Reson Imaging 17: 881–892CrossRefPubMed
24.
Engelbrecht V, Scherer A, Rassek M, et al (2002) Diffusion-weighted MR imaging in the brain in children: findings in the normal brain and in the brain with white matter diseases. Radiology 222: 410–418PubMed
25.
Tanner SF, Ramenghi LA, Ridgway JP, et al (2000) Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants. Am J Roentgenol 174: 1643–1649PubMed
26.
Shimony JS, McKinstry RC, Akbudak E, et al (1999) Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiology 212: 770–784PubMed
27.
Cowley AR (1983) The Dyke Award. Influence of fiber tracts on the CT appearance of cerebral edema: anatomic-pathologic correlation. AJNR 4: 915–925
Metadata
Title
Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence
Authors
J. F. L. Schneider
K. A. Il’yasov
J. Hennig
E. Martin
Publication date
01-04-2004
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 4/2004
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-003-1154-2

Other articles of this Issue 4/2004

Neuroradiology 4/2004 Go to the issue

Announcements

April 2004

Letter to the Editor

Choice of cross size in stereology

Diagnostic Neuroradiology

ADC mapping of the aging frontal lobes in mild cognitive impairment

Diagnostic Neuroradiology

Aneurysmal sub-arachnoid haemorrhage in patients with Noonan syndrome: a report of two cases and review of neurovascular presentations in this syndrome

Interventional Neuroradiology

Intracranial arteriovenous fistula caused by endovascular stent-grafting and dilatation

Diagnostic Neuroradiology

Diffusion abnormalities of the globi pallidi in manganese neurotoxicity