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Open Access 01-01-2022 | Review

Papillary lesions of the breast

Authors: Janina Kulka, Lilla Madaras, Giuseppe Floris, Sigurd F. Lax

Published in: Virchows Archiv | Issue 1/2022

Abstract

Papillary lesions of the breast represent a heterogeneous group of lesions including benign papillomas, papillomas with focal epithelial atypia, fully fledged ductal carcinoma in situ (DCIS) or lobular neoplasia, papillary DCIS, encapsulated papillary carcinomas without or with invasion, solid papillary carcinomas, and invasive papillary carcinomas. A micropapillary pattern characterized by lack of fibrous stalks within the papillae is observed in micropapillary DCIS and invasive micropapillary carcinoma. In addition, a variety of other rare breast lesions reveals a papillary architecture such as tall cell carcinoma with reversed polarity (TCCRP) and mucinous cystadenocarcinoma, adenomyoepithelioma, and secretory carcinoma. In addition, benign lesions such as usual ductal hyperplasia, apocrine metaplasia, gynecomastia, and juvenile papillomatosis may show a papillary or micropapillary architecture. Fragments of a benign papilloma in a breast biopsy are considered a lesion of uncertain malignant potential (B3 in the European classification) and excision is mostly recommended. Although the knowledge about molecular pathology of papillary breast lesions has increased, there is not sufficient evidence for diagnostically useful molecular features, yet. The aim of this review is to provide an update on papillary and micropapillary lesions with emphasis on problematic areas for daily diagnostic work including biopsies.

Abdulwaasey M, Tariq MU, Minhas K, Kayani N (2020) Invasive breast carcinoma arising in a nipple adenoma after 15 years: report of a rare case and literature review. Cureus 12:e8586. https://doi.org/10.7759/cureus.8586CrossRefPubMedPubMedCentral

Acs G, Khakpour N, Kiluk J, Lee MC, Laronga C (2015) The presence of extensive retraction clefts in invasive breast carcinomas correlates with lymphatic invasion and nodal metastasis and predicts poor outcome: a prospective validation study of 2742 consecutive cases. Am J Surg Pathol 39:325–337. https://doi.org/10.1097/PAS.0000000000000339CrossRefPubMed

Adrada B, Arribas E, Gilcrease M, Yang WT (2009) Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol 193:W58-63. https://doi.org/10.2214/AJR.08.1537CrossRefPubMed

Agoumi M, Giambattista J, Hayes MM (2016) Practical considerations in breast papillary lesions: a review of the literature. Arch Pathol Lab Med 140:770–790. https://doi.org/10.5858/arpa.2015-0525-RACrossRefPubMed

Alsadoun N, MacGrogan G, Truntzer C, Lacroix-Triki M, Bedgedjian I, Koeb MH, El Alam E, Medioni D, Parent M, Wuithier P, Robert I, Boidot R, Arnould L (2018) Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases. Mod Pathol 31:1367–1380. https://doi.org/10.1038/s41379-018-0047-1CrossRefPubMed

Alsharif S, Daghistani R, Kamberoglu EA, Omeroglu A, Meterissian S, Mesurolle B (2014) Mammographic, sonographic and MR imaging features of invasive micropapillary breast cancer. Eur J Radiol 83:1375–1380. https://doi.org/10.1016/j.ejrad.2014.05.003CrossRefPubMed

ASBrS (2018) The American Society of Breast Surgeons Consensus Guideline on Concordance Assessment of Image-Guided Breast Biopsies and Management of Borderline or High-Risk Lesions. https://www.breastsurgeons.org/docs/statements/Consensus-Guideline-on-Concordance-Assessment-of-Image-Guided-Breast-Biopsies.pdf

Bianchi S, Bendinelli B, Saladino V, Vezzosi V, Brancato B, Nori J, Palli D (2015) Non-malignant breast papillary lesions - b3 diagnosed on ultrasound--guided 14-gauge needle core biopsy: analysis of 114 cases from a single institution and review of the literature. Pathol Oncol Res 21:535–546. https://doi.org/10.1007/s12253-014-9882-7CrossRefPubMed

Boecker W, Buerger H, Schmitz K, Ellis IA, van Diest PJ, Sinn HP, Geradts J, Diallo R, Poremba C, Herbst H (2001) Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns J Pathol 195:415–421. https://doi.org/10.1002/path.982CrossRefPubMed

10.

Brogi E, Horii R, MacGrogan G, Rakha EA, Troxell ML, Tse M (2019) Papillary neoplasms: introduction. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 49–52

11.

Brogi E, Krystel-Whittemore M (2021) Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy. Mod Pathol 34:78–93. https://doi.org/10.1038/s41379-020-00706-5CrossRefPubMed

12.

Burt M, Madan R, Fan F (2016) Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. Hum Pathol 56:143–146. https://doi.org/10.1016/j.humpath.2016.05.024CrossRefPubMed

13.

Calhoun BC, Collins LC (2016) Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature. Histopathology 68:138–151. https://doi.org/10.1111/his.12852CrossRefPubMed

14.

Castellano I, Marchio C, Tomatis M, Ponti A, Casella D, Bianchi S, Vezzosi V, Arisio R, Pietribiasi F, Frigerio A, Mano MP, Ricardi U, Allia E, Accortanzo V, Durando A, Bussolati G, Tot T, Sapino A (2010) Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study. Mod Pathol 23:260–269. https://doi.org/10.1038/modpathol.2009.169CrossRefPubMed

15.

Chang JM, Han W, Moon WK, Cho N, Noh DY, Park IA, Jung EJ (2011) Papillary lesions initially diagnosed at ultrasound-guided vacuum-assisted breast biopsy: rate of malignancy based on subsequent surgical excision. Ann Surg Oncol 18:2506–2514. https://doi.org/10.1245/s10434-011-1617-3CrossRefPubMed

16.

Chen AC, Paulino AC, Schwartz MR, Rodriguez AA, Bass BL, Chang JC, Teh BS (2014) Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer 111:619–622. https://doi.org/10.1038/bjc.2014.301CrossRefPubMedPubMedCentral

17.

Christgen M, Bartels S, van Luttikhuizen JL, Schieck M, Pertschy S, Kundu S, Lehmann U, Sander B, Pelz E, Langer F, Schlegelberger B, Steinemann D, Kreipe H (2017) Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma J Pathol. Clin Res 3:191–202. https://doi.org/10.1002/cjp2.76CrossRef

18.

Cimino-Mathews A (2021) Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls. Mod Pathol 34:62–77. https://doi.org/10.1038/s41379-020-00697-3CrossRefPubMed

19.

Collins LC, Carlo VP, Hwang H, Barry TS, Gown AM, Schnitt SJ (2006) Intracystic papillary carcinomas of the breast: a reevaluation using a panel of myoepithelial cell markers. Am J Surg Pathol 30:1002–1007. https://doi.org/10.1097/00000478-200608000-00011CrossRefPubMed

20.

Collins LC, Schnitt SJ (2008) Papillary lesions of the breast: selected diagnostic and management issues. Histopathology 52:20–29. https://doi.org/10.1111/j.1365-2559.2007.02898.xCrossRefPubMed

21.

Cserni G (2012) Benign apocrine papillary lesions of the breast lacking or virtually lacking myoepithelial cells-potential pitfalls in diagnosing malignancy. APMIS 120:249–252. https://doi.org/10.1111/j.1600-0463.2011.02840.xCrossRefPubMed

22.

Deman F, Punie K, Laenen A, Neven P, Oldenburger E, Smeets A, Nevelsteen I, Van Ongeval C, Baten A, Faes T, Christiaens M, Janssen H, Weltens C, Desmedt C, Wildiers H, Floris G (2020) Assessment of stromal tumor infiltrating lymphocytes and immunohistochemical features in invasive micropapillary breast carcinoma with long-term outcomes. Breast Cancer Res Treat 184:985–998. https://doi.org/10.1007/s10549-020-05913-xCrossRefPubMed

23.

Di Bonito M, Cantile M, Collina F, D’Aiuto M, Liguori RDEC, Botti G (2014) Adenoma of the nipple: a clinicopathological report of 13 cases. Oncol Lett 7:1839–1842. https://doi.org/10.3892/ol.2014.2000CrossRefPubMedPubMedCentral

24.

Di Cristofano C, Mrad K, Zavaglia K, Bertacca G, Aretini P, Cipollini G, Bevilacqua G, Ben Romdhane K, Cavazzana A (2005) Papillary lesions of the breast: a molecular progression? Breast Cancer Res Treat 90:71–76. https://doi.org/10.1007/s10549-004-3003-3CrossRefPubMed

25.

Duprez R, Wilkerson PM, Lacroix-Triki M, Lambros MB, MacKay A, A’Hern R, Gauthier A, Pawar V, Colombo PE, Daley F, Natrajan R, Ward E, MacGrogan G, Arbion F, Michenet P, Weigelt B, Vincent-Salomon A, Reis-Filho JS (2012) Immunophenotypic and genomic characterization of papillary carcinomas of the breast. J Pathol 226:427–441. https://doi.org/10.1002/path.3032CrossRefPubMed

26.

Foschini MP, Asioli S, Foreid S, Cserni G, Ellis IO, Eusebi V, Rosai J (2017) Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: a unique invasive tumor with indolent behavior. Am J Surg Pathol 41:887–895. https://doi.org/10.1097/PAS.0000000000000853CrossRefPubMed

27.

Foschini MP, Geyer FC, Hayes MM, Marchio C, Nishimura R (2019) Adenomyoepithelioma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 43–45

28.

Foschini MP, Geyer FC, Hayes MM, Marchio C, Nishimura R (2019) Malignant adenomyoepithelioma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 46–48

29.

Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V (2017) The morphological spectrum of salivary gland type tumours of the breast. Pathology 49:215–227. https://doi.org/10.1016/j.pathol.2016.10.011CrossRefPubMed

30.

Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt Reis-Filho BJS (2018) Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun 9:1816. https://doi.org/10.1038/s41467-018-04128-5CrossRefPubMedPubMedCentral

31.

Ginter PS, McIntire PJ, Kurtis B, Mirabelli S, Motanagh S, Hoda S, Elemento O, Shin SJ, Mosquera JM (2020) Adenomyoepithelial tumors of the breast: molecular underpinnings of a rare entity. Mod Pathol 33:1764–1772. https://doi.org/10.1038/s41379-020-0552-xCrossRefPubMed

32.

Gruel N, Benhamo V, Bhalshankar J, Popova T, Freneaux P, Arnould L, Mariani O, Stern MH, Raynal V, Sastre-Garau X, Rouzier R, Delattre O, Vincent-Salomon A (2014) Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Res 16:R46. https://doi.org/10.1186/bcr3653CrossRefPubMedPubMedCentral

33.

Hayes MM (2011) Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J Clin Pathol 64:477–484. https://doi.org/10.1136/jcp.2010.087718CrossRefPubMed

34.

Hoda RS, Brogi E, Pareja F, Nanjangud G, Murray MP, Weigelt B, Reis-Filho JS, Wen HY (2019) Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential. Histopathology 75:213–224. https://doi.org/10.1111/his.13879CrossRefPubMedPubMedCentral

35.

Corben AD, Brogi E (2014) Mucinous carcinoma. In: Hoda SA, Brogi E, Koerner FC, Rosen PP (eds) Rosen’s breast pathology, 4th edn. Lippincott Williams & Wilkins, a Wolters Kluwer business, Philadelphia, pp 621–622

36.

Horowitz DP, Sharma CS, Connolly E, Gidea-Addeo D, Deutsch I (2012) Secretory carcinoma of the breast: results from the survival, epidemiology and end results database. Breast 21:350–353. https://doi.org/10.1016/j.breast.2012.02.013CrossRefPubMed

37.

Jacob JD, Hodge C, Franko J, Pezzi CM, Goldman CD, Klimberg VS (2016) Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base. J Surg Oncol 113:721–725. https://doi.org/10.1002/jso.24241CrossRefPubMed

38.

Jain E, Kumar A, Jain R, Sharma S (2021) Primary mucinous cystadenocarcinoma of the breast: a rare case report with review of literature. Int J Surg Pathol 29:740–746. https://doi.org/10.1177/1066896921991650

39.

Jorns JM (2016) Papillary lesions of the breast: a practical approach to diagnosis. Arch Pathol Lab Med 140:1052–1059. https://doi.org/10.5858/arpa.2016-0219-RACrossRefPubMed

40.

Kader T, Elder K, Zethoven M, Semple T, Hill P, Goode DL, Thio N, Cheasley D, Rowley SM, Byrne DJ, Pang JM, Miligy IM, Green AR, Rakha EA, Fox SB, Mann GB, Campbell IG, Gorringe KL (2020) The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma NPJ. Breast Cancer 6:9. https://doi.org/10.1038/s41523-020-0150-6CrossRefPubMedPubMedCentral

41.

Khoury T, Hu Q, Liu S, Wang J (2014) Intracystic papillary carcinoma of breast: interrelationship with in situ and invasive carcinoma and a proposal of pathogenesis: array comparative genomic hybridization study of 14 cases. Mod Pathol 27:194–203. https://doi.org/10.1038/modpathol.2013.136CrossRefPubMed

42.

Koenig C, Tavassoli FA (1998) Mucinous cystadenocarcinoma of the breast. Am J Surg Pathol 22:698–703. https://doi.org/10.1097/00000478-199806000-00006CrossRefPubMed

43.

Kuehner G, Darbinian J, Habel L, Axelsson K, Butler S, Chang S, Chen R, Fehrenbacher L (2019) Benign papillary breast mass lesions: favorable outcomes with surgical excision or imaging surveillance. Ann Surg Oncol 26:1695–1703. https://doi.org/10.1245/s10434-019-07180-7CrossRefPubMed

44.

Kulka J, Varga Z (2019) Metastases to the breast. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 262–265

45.

Lavoue V, Fritel X, Antoine M, Beltjens F, Bendifallah S, Boisserie-Lacroix M, Boulanger L, Canlorbe G, Catteau-Jonard S, Chabbert-Buffet N, Chamming’s F, Chereau E, Chopier J, Coutant C, Demetz J, Guilhen N, Fauvet R, Kerdraon O, Laas E, Legendre G, Mathelin C, Nadeau C, Naggara IT, Ngo C, Ouldamer L, Rafii A, Roedlich MN, Seror J, Seror JY, Touboul C, Uzan C, E Darai French College of G, Obstetricians (2016) Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF): benign breast tumors - short text. Eur J Obstet Gynecol Reprod Biol 200:16–23. https://doi.org/10.1016/j.ejogrb.2016.02.017CrossRefPubMed

46.

Lewis JT, Hartmann LC, Vierkant RA, Maloney SD, Shane Pankratz V, Allers TM, Frost MH, Visscher DW (2006) An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. Am J Surg Pathol 30:665–672. https://doi.org/10.1097/00000478-200606000-00001CrossRefPubMed

47.

Li D, Xiao X, Yang W, Shui R, Tu X, Lu H, Shi D (2012) Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. Mod Pathol 25:567–575. https://doi.org/10.1038/modpathol.2011.190CrossRefPubMed

48.

Liau JY, Lee YH, Tsai JH, Yuan CT, Chu CY, Hong JB, Sheen YS (2017) Frequent PIK3CA activating mutations in nipple adenomas. Histopathology 70:195–202. https://doi.org/10.1111/his.13043CrossRefPubMed

49.

Lin LH, Ozerdem U, Cotzia P, Lee J, Chun J, Schnabel F, Darvishian F (2021) Upgrade rate of intraductal papilloma diagnosed on core needle biopsy in a single institution. Hum Pathol 110:43–49. https://doi.org/10.1016/j.humpath.2020.10.012CrossRefPubMed

50.

Mac Grogan G, Collins LC, Lerwill M, Rakha E, Tan BY (2019) Encapsulated papillary carcinoma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 60–62

51.

Mac Grogan G, Collins LC, Lerwill M, Rakha E, Tan BY (2019) Solid papillary carcinoma (in situ and invasive). In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 63–65

52.

MacColl C, Salehi A, Parpia S, Hodgson N, Ramonas M, Williams P (2019) Benign breast papillary lesions diagnosed on core biopsy: upgrade rate and risk factors associated with malignancy on surgical excision. Virchows Arch 475:701–707. https://doi.org/10.1007/s00428-019-02626-5CrossRefPubMed

53.

Maluf HM, Koerner FC (1995) Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma Am J Surg Pathol 19:1237–1244. https://doi.org/10.1097/00000478-199511000-00003CrossRefPubMed

54.

Marchio C, Horlings HM, Vincent-Salomon A (2019) Invasive micropapillary carcinoma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 128–130

55.

Marchio C, Iravani M, Natrajan R, Lambros MB, Geyer FC, Savage K, Parry S, Tamber N, Fenwick K, Mackay A, Schmitt FC, Bussolati G, Ellis I, Ashworth A, Sapino A, Reis-Filho JS (2009) Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components. J Pathol 218:301–315. https://doi.org/10.1002/path.2572CrossRefPubMed

56.

Marchio C, Iravani M, Natrajan R, Lambros MB, Savage K, Tamber N, Fenwick K, Mackay A, Senetta R, Di Palma S, Schmitt FC, Bussolati G, Ellis LO, Ashworth A, Sapino A, Reis-Filho JS (2008) Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. J Pathol 215:398–410. https://doi.org/10.1002/path.2368CrossRefPubMed

57.

Moritz AW, Wiedenhoefer JF, Profit AP, Jagirdar J (2016) Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: A case series emphasizing histologic, radiologic, and clinical correlation. Breast 29:132–139. https://doi.org/10.1016/j.breast.2016.07.018CrossRefPubMed

58.

Moseley T, Desai B, Whitman GJ, Robinson EK, Saunders T, Gonzalez A, He H (2021) Benign breast intraductal papillomas without atypia at core needle biopsies: is surgical excision necessary? Ann Surg Oncol 28:1347–1355. https://doi.org/10.1245/s10434-020-09061-wCrossRefPubMed

59.

Motanagh SA, Muller KE (2020) Invasive lobular carcinoma with papillary features: a newly described variant that poses a difficult histologic differential diagnosis. Breast J 26:1231–1233. https://doi.org/10.1111/tbj.13784CrossRefPubMed

60.

Moynihan A, Quinn EM, Smith CS, Stokes M, Kell M, Barry JM, Walsh SM (2020) Benign breast papilloma: is surgical excision necessary? Breast J 26:705–710. https://doi.org/10.1111/tbj.13642CrossRefPubMed

61.

Mulligan AM, O’Malley FP (2007) Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastases. Int J Surg Pathol 15:143–147. https://doi.org/10.1177/1066896906299119CrossRefPubMed

62.

Nakhlis F, Baker GM, Pilewskie M, Gelman R, Calvillo KZ, Ludwig K, McAuliffe PF, Willey S, Rosenberger LH, Parker C, Gallagher K, Jacobs L, Feldman S, Lange P, DeSantis SD, Schnitt SJ, King TA (2021) The incidence of adjacent synchronous invasive carcinoma and/or ductal carcinoma in situ in patients with intraductal papilloma without atypia on core biopsy: results from a prospective multi-institutional registry (TBCRC 034). Ann Surg Oncol 28:2573–2578. https://doi.org/10.1245/s10434-020-09215-wCrossRefPubMed

63.

Natrajan R, Wilkerson PM, Marchio C, Piscuoglio S, Ng CK, Wai P, Lambros MB, Samartzis EP, Dedes KJ, Frankum J, Bajrami I, Kopec A, Mackay A, A’Hern R, Fenwick K, Kozarewa I, Hakas J, Mitsopoulos C, Hardisson D, Lord CJ, Kumar-Sinha C, Ashworth A, Weigelt B, Sapino A, Chinnaiyan AM, Maher CA, Reis-Filho JS (2014) Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. J Pathol 232:553–565. https://doi.org/10.1002/path.4325CrossRefPubMedPubMedCentral

64.

Ni YB, Tse GM (2016) Pathological criteria and practical issues in papillary lesions of the breast - a review. Histopathology 68:22–32. https://doi.org/10.1111/his.12866CrossRefPubMed

65.

Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, Ogawa H, Nasuno H, Serizawa A, Kobayashi H (2007) Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int 57:421–429. https://doi.org/10.1111/j.1440-1827.2007.02118.xCrossRefPubMed

66.

Pareja F, Corben AD, Brennan SB, Murray MP, Bowser ZL, Jakate K, Sebastiano C, Morrow M, Morris EA, Brogi E (2016) Breast intraductal papillomas without atypia in radiologic-pathologic concordant core-needle biopsies: rate of upgrade to carcinoma at excision. Cancer 122:2819–2827. https://doi.org/10.1002/cncr.30118CrossRefPubMed

67.

Parikh P, Jameel Z, Falcon S, Rosa M, Kiluk J, Hoover S, Soliman H, Ataya D (2021) Adenomyoepithelioma of the breast: case series and literature review. Clin Imaging 75:157–164. https://doi.org/10.1016/j.clinimag.2021.02.002CrossRefPubMed

68.

Piscuoglio S, Ng CK, Martelotto LG, Eberle CA, Cowell CF, Natrajan R, Bidard FC, De Mattos-Arruda L, Wilkerson PM, Mariani O, Vincent-Salomon A, Weigelt B, Reis-Filho JS (2014) Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Mol Oncol 8:1588–1602. https://doi.org/10.1016/j.molonc.2014.06.011CrossRefPubMedPubMedCentral

69.

Rageth CJ, O’Flynn EAM, Pinker K, Kubik-Huch RA, Mundinger A, Decker T, Tausch C, Dammann F, Baltzer PA, Fallenberg EM, Foschini MP, Dellas S, Knauer M, Malhaire C, Sonnenschein M, Boos A, Morris E, Varga Z (2019) Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Res Treat 174:279–296. https://doi.org/10.1007/s10549-018-05071-1CrossRefPubMed

70.

Rakha E, Hoon Tan P, Ellis I, Quinn C (2021). Adenomyoepithelioma of the breast: a proposal for classification Histopathology. https://doi.org/10.1111/his.14380CrossRefPubMed

71.

Rakha EA (2016) Morphogenesis of the papillary lesions of the breast: phenotypic observation. J Clin Pathol 69:64–69. https://doi.org/10.1136/jclinpath-2015-203191CrossRefPubMed

72.

Rakha EA, Abbas A, Sheeran R (2016) Invasive lobular carcinoma mimicking papillary carcinoma: a report of three cases. Pathobiology 83:221–227. https://doi.org/10.1159/000442884CrossRefPubMed

73.

Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO (2016) Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management. Histopathology 68:45–56. https://doi.org/10.1111/his.12861CrossRefPubMedPubMedCentral

74.

Rakha EA, Ellis IO (2018) Diagnostic challenges in papillary lesions of the breast. Pathology 50:100–110. https://doi.org/10.1016/j.pathol.2017.10.005CrossRefPubMed

75.

Rakha EA, Gandhi N, Climent F, van Deurzen CH, Haider SA, Dunk L, Lee AH, Macmillan D, Ellis IO (2011) Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis. Am J Surg Pathol 35:1093–1103. https://doi.org/10.1097/PAS.0b013e31821b3f65CrossRefPubMed

76.

Rakha EA, Varga Z, Elsheik S, Ellis IO (2015) High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity. Histopathology 66:740–746. https://doi.org/10.1111/his.12591CrossRefPubMed

77.

RCPath (2016) The Royal College of Pathologists. Guidelines for non-operative diagnostic procedures and reporting in breast cancer screening. https://www.rcpath.org/uploads/assets/4b16f19c-f7bd-456c-b212f557f8040f66/G150-Non-op-reporting-breast-cancer-screening-Feb17.pdf

78.

Rosen PP, Caicco JA (1986) Florid papillomatosis of the nipple. A study of 51 patients, including nine with mammary carcinoma. Am J Surg Pathol 10:87–101CrossRef

79.

Roviello G, D’Angelo A, Sciortino M, Mini E, Nobili S, De Logu F, Massi D (2020) TRK fusion positive cancers: from first clinical data of a TRK inhibitor to future directions. Crit Rev Oncol Hematol 152:103011. https://doi.org/10.1016/j.critrevonc.2020.103011CrossRefPubMed

80.

Shui R, Cheng Y, Bai Q, Yang W (2017) Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. Histopathology 71:488–493. https://doi.org/10.1111/his.13232CrossRefPubMed

81.

Tabar L, Vitak B, Chen HH, Duffy SW, Yen MF, Chiang CF, Krusemo UB, Tot T, Smith RA (2000) The Swedish Two-County Trial twenty years later. Updated mortality results and new insights from long-term follow-up Radiol Clin North Am 38:625–651. https://doi.org/10.1016/s0033-8389(05)70191-3CrossRefPubMed

82.

Tavassoli FA, Eusebi V (2009) Carcinomas of low-grade malignancy. In: Silverberg SG, Sobin LH, Gardner WA (eds) Tumors of the mammary gland American Registry of Pathology in collaboration with Armed Forces Institute of Pathology Washington D.C, series 4, pp 194–195

83.

Tay TKY, Tan PH (2021) Papillary neoplasms of the breast-reviewing the spectrum. Mod Pathol 34:1044–1061. https://doi.org/10.1038/s41379-020-00732-3CrossRefPubMed

84.

Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PH (2002) Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2:367–376. https://doi.org/10.1016/s1535-6108(02)00180-0CrossRefPubMed

85.

Troxell ML, Boulos F, Denkert C, Horii R, Yamaguchi R (2019) Intraductal papilloma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 52–56

86.

Turashvili G, Brogi E, Morrow M, Hudis C, Dickler M, Norton L, Wen HY (2017) The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Breast Cancer Res Treat 165:65–76. https://doi.org/10.1007/s10549-017-4326-1CrossRefPubMedPubMedCentral

87.

Vasudev P, Onuma K (2011) Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. Arch Pathol Lab Med 135:1606–1610. https://doi.org/10.5858/arpa.2010-0351-RSCrossRefPubMed

88.

Wei S (2016) Papillary lesions of the breast: an update. Arch Pathol Lab Med 140:628–643. https://doi.org/10.5858/arpa.2015-0092-RACrossRefPubMed

89.

Weiss LM, Funari VA (2021) NTRK fusions and Trk proteins: what are they and how to test for them. Hum Pathol 112:59–69. https://doi.org/10.1016/j.humpath.2021.03.007CrossRefPubMed

90.

Wen HY, Desmedt C, Reis-Filho JS, Schmitt F (2019) Mucinous cystadenocarcinoma. In: WHO classification of tumours editorial board. Breast Tumours, Lyon (France), International Agency for Research on Cancer (WHO classification of tumours series, 5th edn, vol 2), pp 126–127

91.

Wilsher MJ, Desai AJ, Pinder SE (2020) Low-grade adenosquamous carcinoma arising in association with a nipple adenoma. Histopathology 76:784–787. https://doi.org/10.1111/his.14033CrossRefPubMed

92.

Wynveen CA, Nehhozina T, Akram M, Hassan M, Norton L, Van Zee KJ, Brogi E (2011) Intracystic papillary carcinoma of the breast: an in situ or invasive tumor? Results of immunohistochemical analysis and clinical follow-up Am J Surg Pathol 35:1–14. https://doi.org/10.1097/PAS.0b013e3181fbe20aCrossRefPubMed

93.

Yoshida M, Tsuda H, Yamamoto S, Kinoshita T, Akashi-Tanaka S, Hojo T, Fukutomi T (2012) Loss of heterozygosity on chromosome 16q suggests malignancy in core needle biopsy specimens of intraductal papillary breast lesions. Virchows Arch 460:497–504. https://doi.org/10.1007/s00428-012-1200-8CrossRefPubMed

94.

Zhong E, Scognamiglio T, D’Alfonso T, Song W, Tran H, Baek I, Hoda SA (2019) Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: molecular characterization by next-generation sequencing and histopathological comparison with tall cell papillary carcinoma of thyroid. Int J Surg Pathol 27:134–141. https://doi.org/10.1177/1066896918800779CrossRefPubMed

95.

Zhou S, Yang F, Bai Q, Li A, Li M, Zhong S, Lv H, Shui R, Tu X, Bi R, Xu X, Cheng Y, Yu B, Tang S, Sun X, Zhou X, Yang W (2020) Intense basolateral membrane staining indicates HER2 positivity in invasive micropapillary breast carcinoma. Mod Pathol 33:1275–1286. https://doi.org/10.1038/s41379-020-0461-zCrossRefPubMed

Title: Papillary lesions of the breast
Authors: Janina Kulka
Lilla Madaras
Giuseppe Floris
Sigurd F. Lax
Publication date: 01-01-2022
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 1/2022
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-021-03182-7

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Papillary lesions of the breast

Abstract

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Abstract

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