What’s new in nerve sheath tumors

1.

Fetsch JF, Michal M, Miettinen M (2000) Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. Am J Surg Pathol 24:331–343. https://doi.org/10.1097/00000478-200003000-00001CrossRefPubMed

2.

Evans HL (2013) Sporadic superficial diffuse neurofibromas with repeated local recurrence over many years and a tendency toward malignant change: a report of 3 cases. Am J Surg Pathol 37:987–994. https://doi.org/10.1097/PAS.0b013e31827c96f4CrossRefPubMed

3.

Michal M, Kazakov DV, Hadravský L, Michalová K, Rychlý B, Michal M (2017) Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases. Hum Pathol 60:167–173. https://doi.org/10.1016/j.humpath.2016.10.010CrossRefPubMed

4.

Pižem J, Nicholson KM, Mraz J, Prieto VG (2013) Melanocytic differentiation is present in a significant proportion of nonpigmented diffuse neurofibromas: a potential diagnostic pitfall. Am J Surg Pathol 37:1182–1191. https://doi.org/10.1097/PAS.0b013e31828950a3CrossRefPubMed

5.

Laycock-Van Spyk S, Thomas N, Cooper DN, Upadhyaya M (2011) Neurofibromatosis type 1-associated tumours: their somatic mutational spectrum and pathogenesis. Hum Genomics 5:623–690. https://doi.org/10.1186/1479-7364-5-6-623CrossRefPubMed

6.

Husain S, Silvers DN (2013) Fingerprint CD34 immunopositivity to distinguish neurofibroma from an early/paucicellular desmoplastic melanoma can be misleading. J Cutan Pathol 40:985–987. https://doi.org/10.1111/cup.12206CrossRefPubMed

7.

Yeh I, McCalmont TH (2011) Distinguishing neurofibroma from desmoplastic melanoma: the value of the cd34 fingerprint. J Cutan Pathol 38:625–630. https://doi.org/10.1111/j.1600-0560.2011.01700.xCrossRefPubMed

8.

Elsensohn A, Shiu J, Grove N, Hosking AM, Barr R, de Feraudy S (2018) Distinguishing neurofibroma from desmoplastic melanoma: the value of p53. Am J Surg Pathol 42:372–375. https://doi.org/10.1097/PAS.0000000000000978CrossRefPubMedPubMedCentral

9.

Azizi AA, Slavc I, Theisen BE et al (2018) Monitoring of plexiform neurofibroma in children and adolescents with neurofibromatosis type 1 by [ 18 F]FDG-PET imaging. Is it of value in asymptomatic patients? Pediatr Blood Cancer 65:e26733. https://doi.org/10.1002/pbc.26733CrossRef

10.

Beert E, Brems H, Daniëls B, de Wever I, van Calenbergh F, Schoenaers J, Debiec-Rychter M, Gevaert O, de Raedt T, van den Bruel A, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E (2011) Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes Chromosomes Cancer 50:1021–1032. https://doi.org/10.1002/gcc.20921CrossRefPubMed

11.

Miettinen MM, Antonescu CR, Fletcher CDM, Kim A, Lazar AJ, Quezado MM, Reilly KM, Stemmer-Rachamimov A, Stewart DR, Viskochil D, Widemann B, Perry A (2017) Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1—a consensus overview. Hum Pathol 67:1–10. https://doi.org/10.1016/j.humpath.2017.05.010CrossRefPubMedPubMedCentral

12.

Higham CS, Dombi E, Rogiers A, Bhaumik S, Pans S, Connor SEJ, Miettinen M, Sciot R, Tirabosco R, Brems H, Baldwin A, Legius E, Widemann BC, Ferner RE (2018) The characteristics of 76 atypical neurofibromas as precursors to neurofibromatosis 1 associated malignant peripheral nerve sheath tumors. Neuro Oncol 20:818–825. https://doi.org/10.1093/neuonc/noy013CrossRefPubMedPubMedCentral

13.

Bernthal NM, Putnam A, Jones KB, Viskochil D, Randall RL (2014) The effect of surgical margins on outcomes for low grade MPNSTs and atypical neurofibroma. J Surg Oncol 110:813–816. https://doi.org/10.1002/jso.23736CrossRefPubMed

14.

Nielsen GP, Stemmer-Rachamimov AO, Ino Y et al (1999) Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Am J Pathol 155:1879–1884. https://doi.org/10.1016/S0002-9440(10)65507-1CrossRefPubMedPubMedCentral

15.

Erstine EM, Ko JS, Rubin BP, McKenney J, Goldblum JR, Billings SD (2017) Broadening the anatomic landscape of sclerosing perineurioma. Am J Dermatopathol 39:679–681. https://doi.org/10.1097/dad.0000000000000773CrossRefPubMed

16.

Hornick JL, Fletcher CDM (2005) Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 29:845–858. https://doi.org/10.1097/01.pas.0000155166.86409.d2CrossRefPubMed

17.

Graadt Van Roggen JF, McMenamin ME, Belchis DA et al (2001) Reticular perineurioma: a distinctive variant of soft tissue perineurioma. Am J Surg Pathol 25:485–493. https://doi.org/10.1097/00000478-200104000-00008CrossRefPubMed

18.

Michal M, Kazakov DV, Agaimy A, Hosova M, Michalova K, Grossmann P, Steiner P, Skenderi F, Vranic S, Michal M (2017) Whorling cellular perineurioma: a previously undescribed variant closely mimicking monophasic fibrous synovial sarcoma. Ann Diagn Pathol 27:74–78. https://doi.org/10.1016/j.anndiagpath.2017.02.001CrossRefPubMed

19.

Torres-Mora J, Ud Din N, Ahrens WA, Folpe AL (2016) Pseudolipoblastic perineurioma: an unusual morphological variant of perineurioma that may simulate liposarcoma. Hum Pathol 57:22–27. https://doi.org/10.1016/j.humpath.2016.06.017CrossRefPubMed

20.

Agaimy A (2014) Microscopic intraneural perineurial cell proliferations in patients with neurofibromatosis type 1. Ann Diagn Pathol 18:95–98. https://doi.org/10.1016/j.anndiagpath.2013.12.005CrossRefPubMed

21.

Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM (2007) Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma - a study from the French sarcoma gr. Am J Surg Pathol 31:1387–1402. https://doi.org/10.1097/PAS.0b013e3180321959CrossRefPubMed

22.

Doyle LA, Möller E, Cin PD et al (2011) MUC4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma. Am J Surg Pathol 35:733–741. https://doi.org/10.1097/PAS.0b013e318210c268CrossRefPubMed

23.

Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (1994) Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet 7:502–508. https://doi.org/10.1038/ng0894-502CrossRefPubMed

24.

Hirose T, Scheithauer BW, Sano T (1998) Perineurial malignant peripheral nerve sheath tumor (MPNST): a clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol 22:1368–1378. https://doi.org/10.1097/00000478-199811000-00007CrossRefPubMed

25.

Schrader KA, Nelson TN, De Luca A et al (2009) Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clin Genet 75:185–189. https://doi.org/10.1111/j.1399-0004.2008.01100.xCrossRefPubMed

26.

Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG (1998) Malignant granular cell tumor of soft tissue. Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 22:779–794. https://doi.org/10.1097/00000478-199807000-00001CrossRefPubMed

27.

Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S (2016) Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study. Int J Clin Oncol 21:808–816. https://doi.org/10.1007/s10147-016-0949-1CrossRefPubMed

28.

Pareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, Alemar B, Bi R, Lim RS, de Bruijn I, Fujisawa S, Gardner R, Feng E, Li A, da Silva EM, Lozada JR, Blecua P, Cohen-Gould L, Jungbluth AA, Rakha EA, Ellis IO, Edelweiss MIA, Palazzo J, Norton L, Hollmann T, Edelweiss M, Rubin BP, Weigelt B, Reis-Filho JS (2018) Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun 9:3533. https://doi.org/10.1038/s41467-018-05886-yCrossRefPubMedPubMedCentral

29.

Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H (2019) Frequent mutations of genes encoding vacuolar H + -ATPase components in granular cell tumors. Genes Chromosomes Cancer 58:373–380. https://doi.org/10.1002/gcc.22727CrossRefPubMed

30.

Lazar AJF, Fletcher CDM (2005) Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases. Am J Surg Pathol 29:927–934. https://doi.org/10.1097/01.pas.0000157294.55796.d3CrossRefPubMed

31.

Perret RE, Jullie ML, Vergier B, Coindre JM, le Loarer F (2018) A subset of so-called dermal non-neural granular cell tumours are underlined by ALK fusions, further supporting the idea that they represent a variant of epithelioid fibrous histiocytoma. Histopathology 73:532–534. https://doi.org/10.1111/his.13645CrossRefPubMed

32.

Cohen JN, Yeh I, Jordan RC, Wolsky RJ, Horvai AE, McCalmont T, LeBoit P (2018) Cutaneous non-neural granular cell tumors harbor. Am J Surg Pathol 42:1133–1142. https://doi.org/10.1097/PAS.0000000000001122CrossRefPubMed

33.

Liegl B, Bennett MW, Fletcher CDM (2008) Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations. Am J Surg Pathol 32:1080–1087. https://doi.org/10.1097/PAS.0b013e318160cfdaCrossRefPubMed

34.

Luzar B, Tanaka M, Schneider J, Calonje E (2016) Cutaneous microcystic/reticular schwannoma: a poorly recognized entity. J Cutan Pathol 43:93–100. https://doi.org/10.1111/cup.12624CrossRefPubMed

35.

Koubaa Mahjoub W, Jouini R, Khanchel F, Ben Brahim E, Llamas-Velasco M, Helel I, Khayat O, Chadli A, Badri T, Mentzel T (2019) Neuroblastoma-like schwannoma with giant rosette: a potential diagnostic pitfall for hyalinizing spindle cell tumor. J Cutan Pathol 46:234–237. https://doi.org/10.1111/cup.13405CrossRefPubMed

36.

Chuang ST, Wang HL (2007) An unusual case of glandular schwannoma. Hum Pathol 38:673–677. https://doi.org/10.1016/j.humpath.2006.10.016CrossRefPubMed

37.

Holliday AC, Mazloom SE, Coman GC, Kolodney MS, Chavan RN, Grider DJ (2017) Benign glandular schwannoma with ancient change. Am J Dermatopathol 39:300–303. https://doi.org/10.1097/DAD.0000000000000739CrossRefPubMed

38.

Lodding P, Kindblom LG, Angervall L, Stenman G (1990) Cellular schwannoma - a clinicopathologic study of 29 cases. Virchows Arch A Pathol Anat Histopathol 416:237–248. https://doi.org/10.1007/BF01678983CrossRefPubMed

39.

White W, Shiu MH, Rosenblum MK, Erlandson RA, Woodruff JM (1990) Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumors. Cancer 66:1266–1275. https://doi.org/10.1002/1097-0142(19900915)66:6<1266::AID-CNCR2820660628>3.0.CO;2-ECrossRefPubMed

40.

Hart J, Gardner JM, Edgar M, Weiss SW (2016) Epithelioid schwannomas: an analysis of 58 cases including atypical variants. Am J Surg Pathol 40:704–713. https://doi.org/10.1097/PAS.0000000000000589CrossRefPubMed

41.

Jo VY, Fletcher CDM (2017) SMARCB1/INI1 loss in epithelioid schwannoma. Am J Surg Pathol 41:1013–1022. https://doi.org/10.1097/PAS.0000000000000849CrossRefPubMed

42.

McMenamin ME, Fletcher CDM (2001) Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. Am J Surg Pathol 25:13–25. https://doi.org/10.1097/00000478-200101000-00002CrossRefPubMed

43.

Caltabiano R, Magro G, Polizzi A, Praticò AD, Ortensi A, D'Orazi V, Panunzi A, Milone P, Maiolino L, Nicita F, Capone GL, Sestini R, Paganini I, Muglia M, Cavallaro S, Lanzafame S, Papi L, Ruggieri M (2017) A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Child’s Nerv Syst 33:933–940. https://doi.org/10.1007/s00381-017-3340-2CrossRef

44.

Kehrer-Sawatzki H, Farschtschi S, Mautner VF, Cooper DN (2017) The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis. Hum Genet 136:129–148. https://doi.org/10.1007/s00439-016-1753-8CrossRefPubMed

45.

Kehrer-Sawatzki H, Kordes U, Seiffert S et al (2018) Co-occurrence of schwannomatosis and rhabdoid tumor predisposition syndrome 1. Mol Genet Genomic Med 6:627–637. https://doi.org/10.1002/mgg3.412CrossRefPubMedCentral

46.

Agaimy A, Foulkes WD (2018) Hereditary SWI/SNF complex deficiency syndromes. Semin Diagn Pathol 35:193–198. https://doi.org/10.1053/j.semdp.2018.01.002CrossRefPubMed

47.

Patil S, Perry A, MacCollin M et al (2008) Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas. Brain Pathol 18:517–519. https://doi.org/10.1111/j.1750-3639.2008.00155.xCrossRefPubMedPubMedCentral

48.

Carter JM, O’Hara C, Dundas G et al (2012) Epithelioid malignant peripheral nerve sheath tumor arising in a schwannoma, in a patient with “neuroblastoma-like” schwannomatosis and a novel germline SMARCB1 mutation. Am J Surg Pathol 36:154–160. https://doi.org/10.1097/PAS.0b013e3182380802CrossRefPubMedPubMedCentral

49.

Sulhyan KR, Deshmukh BD, Deshmukh D et al (2017) Case report neuroblastoma-like schwannoma in a case of schwannomatosis: report of a rare case. Int J Health Sci (Qassim) 9:1–4. https://doi.org/10.12816/0031629CrossRef

50.

Jo VY, Antonescu CR, Zhang L, Dal Cin P, Hornick JL, Fletcher CD (2013) Cutaneous syncytial myoepithelioma: clinicopathologic characterization in a series of 38 cases. Am J Surg Pathol 37:710–718. https://doi.org/10.1097/PAS.0b013e3182772bbaCrossRefPubMedPubMedCentral

51.

Miettinen M, McCue PA, Sarlomo-Rikala M, Biernat W, Czapiewski P, Kopczynski J, Thompson LD, Lasota J, Wang Z, Fetsch JF (2015) Sox10 - a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol 39:826–835. https://doi.org/10.1097/PAS.0000000000000398CrossRefPubMedPubMedCentral

52.

Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A (2015) Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol 28:187–200. https://doi.org/10.1038/modpathol.2014.109CrossRefPubMed

53.

Michal M, Kazakov DV, Michal M (2017) Hybrid peripheral nerve sheath tumors: a review. Cesk Patol 53:81–88PubMed

54.

Kacerovska D, Michal M, Kuroda N, Tanaka A, Sima R, Denisjuk N, Kreuzberg B, Ricarova R, Kazakov DV (2013) Hybrid peripheral nerve sheath tumors, including a malignant variant in type 1 neurofibromatosis. Am J Dermatopathol 35:641–649. https://doi.org/10.1097/DAD.0b013e31827e2917CrossRefPubMed

55.

Izquierdo FM, Suárez-Vilela D, Honrado E (2013) Intraneural hybrid granular cell tumor-perineurioma. Apmis 121:678–680. https://doi.org/10.1111/apm.12038CrossRefPubMed

56.

Kim SS, Choi YD, Lee JH, Choi C, Park CS (2014) Hybrid granular cell tumor / perineurioma. Korean J Pathol 48:409–412. https://doi.org/10.4132/KoreanJPathol.2014.48.6.409CrossRefPubMedPubMedCentral

57.

Zarineh A, Costa ME, Rabkin MS (2008) Multiple hybrid granular cell tumor-perineuriomas. Am J Surg Pathol 32:1572–1577. https://doi.org/10.1097/PAS.0b013e318170f295CrossRefPubMed

58.

Stahn V, Nagel I, Fischer-Huchzermeyer S, Oyen F, Schneppenheim R, Gesk S, Bohring A, Chikobava L, Young P, Gess B, Werner M, Senner V, Harder A (2016) Molecular analysis of hybrid neurofibroma/schwannoma identifies common monosomy 22 and α-T-catenin/CTNNA3 as a novel candidate tumor suppressor. Am J Pathol 186:3285–3296. https://doi.org/10.1016/j.ajpath.2016.08.019CrossRefPubMed

59.

Kazakov DV, Pitha J, Sima R, Vanecek T, Shelekhova K, Mukensnabl P, Michal M (2005) Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma. A report of three cases in extradigital locations. Ann Diagn Pathol 9:16–23. https://doi.org/10.1016/j.anndiagpath.2004.12.001CrossRefPubMed

60.

Rodriguez FJ, Folpe AL, Giannini C, Perry A (2012) Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 123:295–319. https://doi.org/10.1007/s00401-012-0954-zCrossRefPubMedPubMedCentral

61.

Hornick JL, Bundock EA, Fletcher CDM (2009) Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol 33:1554–1561. https://doi.org/10.1097/PAS.0b013e3181accc6cCrossRefPubMed

62.

Lindholm K, Moran CA (2018) Primary mediastinal melanotic schwannian tumors: a clinicopathological and immunohistochemical study of 5 cases. Ann Diagn Pathol 37:103–106. https://doi.org/10.1016/j.anndiagpath.2018.10.001CrossRefPubMed

63.

Alexiev BA, Chou PM, Jennings LJ (2018) Pathology of melanotic schwannoma. Arch Pathol Lab Med 142:1517–1523. https://doi.org/10.5858/arpa.2017-0162-RACrossRefPubMed

64.

Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL (2014) Malignant melanotic schwannian tumor. Am J Surg Pathol 38:94–105. https://doi.org/10.1097/pas.0b013e3182a0a150CrossRefPubMed

65.

Le Guellec S, Decouvelaere AV, Filleron T et al (2016) Malignant peripheral nerve sheath tumor is a challenging diagnosis. Am J Surg Pathol 40:896–908. https://doi.org/10.1097/PAS.0000000000000655CrossRefPubMed

66.

Valentin T, Le Cesne A, Ray-Coquard I et al (2016) Management and prognosis of malignant peripheral nerve sheath tumors: the experience of the French Sarcoma Group (GSF-GETO). Eur J Cancer 56:77–84. https://doi.org/10.1016/j.ejca.2015.12.015CrossRefPubMed

67.

Allison KH, Patel RM, Goldblum JR, Rubin BP (2005) Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis. Am J Clin Pathol 124:685–692. https://doi.org/10.1309/V8XMK5R78Q96V090CrossRefPubMed

68.

Miki Y, Thway K (2017) Malignant peripheral nerve sheath tumor with divergent glandular differentiation. Int J Surg Pathol 25:310–313. https://doi.org/10.1177/1066896917696749CrossRefPubMed

69.

MacHado I, Arana E, Cruz J et al (2016) Malignant peripheral nerve sheath tumor with osseous heterologous differentiation in uncommon locations (heart and retropharynx). Int J Surg Pathol 24:456–462. https://doi.org/10.1177/1066896916632908CrossRefPubMed

70.

Thway K, Hamarneh W, Miah AB, Fisher C (2015) Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous and glandular elements: rare epithelial differentiation in a triton tumor. Int J Surg Pathol 23:377–383. https://doi.org/10.1177/1066896915583996CrossRefPubMed

71.

Mentzel T, Katenkamp D (1999) Intraneural angiosarcoma and angiosarcoma arising in benign and malignant peripheral nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases. Histopathology 35:114–120. https://doi.org/10.1046/j.1365-2559.1999.00714.xCrossRefPubMed

72.

Guo A, Liu A, Wei L, Song X (2012) Malignant peripheral nerve sheath tumors: differentiation patterns and immunohistochemical features - a mini-review and our new findings. J Cancer 3:303–309. https://doi.org/10.7150/jca.4179CrossRefPubMedPubMedCentral

73.

Ersen A, Pekmezci M, Folpe AL, Tihan T (2017) Comparision of new diagnostic tools for malignant peripheral nerve sheath tumors. Pathol Oncol Res 23:393–398. https://doi.org/10.1007/s12253-016-0125-yCrossRefPubMed

74.

Chen WS, Chen PL, Lu D, Lind AC, Dehner LP (2014) Growth-associated protein 43 in differentiating peripheral nerve sheath tumors from other non-neural spindle cell neoplasms. Mod Pathol 27:184–193. https://doi.org/10.1038/modpathol.2013.128CrossRefPubMed

75.

Schaefer IM, Fletcher CDM, Hornick JL (2016) Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Mod Pathol 29:4–13. https://doi.org/10.1038/modpathol.2015.134CrossRefPubMed

76.

Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M, Zhu S, Cao Z, Liang Y, Sboner A, Tap WD, Fletcher JA, Huberman KH, Qin LX, Viale A, Singer S, Zheng D, Berger MF, Chen Y, Antonescu CR, Chi P (2014) PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet 46:1227–1232. https://doi.org/10.1038/ng.3095CrossRefPubMedPubMedCentral

77.

Cleven AHGG, Al SGA, Briaire-de Bruijn I et al (2016) Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Mod Pathol 29:582–590. https://doi.org/10.1038/modpathol.2016.45CrossRefPubMedPubMedCentral

78.

Cheah AL, Billings SD, Goldblum JR, Carver P, Tanas MZ, Rubin BP (2014) STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology 46:389–395. https://doi.org/10.1097/PAT.0000000000000122CrossRefPubMed

79.

Makise N, Sekimizu M, Konishi E, Motoi T, Kubo T, Ikoma H, Watanabe SI, Okuma T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A (2019) H3K27me3 deficiency defines a subset of dedifferentiated chondrosarcomas with characteristic clinicopathological features. Mod Pathol 32:435–445. https://doi.org/10.1038/s41379-018-0140-5CrossRefPubMed

80.

Jo VY, Fletcher CDM (2015) Epithelioid malignant peripheral nerve sheath tumor: clinicopathologic analysis of 63 cases. Am J Surg Pathol 39:673–682. https://doi.org/10.1097/PAS.0000000000000379CrossRefPubMed

81.

Luzar B, Shanesmith R, Ramakrishnan R, Fisher C, Calonje E (2016) Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases. Histopathology 68:286–296. https://doi.org/10.1111/his.12756CrossRefPubMed

82.

Jo VY, Fletcher CDM (2015) Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features. Head Neck Pathol 9:32–38. https://doi.org/10.1007/s12105-015-0618-0CrossRefPubMedPubMedCentral

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

What’s new in nerve sheath tumors

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2020

What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification

What is new in endothelial neoplasia?

Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma

What’s new in fibroblastic tumors?

What is new in pericytomatous, myoid, and myofibroblastic tumors?

Update on selected advances in the immunohistochemical and molecular genetic analysis of soft tissue tumors