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01-11-2019 | Metastasis | Brief Report

Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma

Authors: Yasuhiko Mizuguchi, Taku Sakamoto, Taiki Hashimoto, Shunsuke Tsukamoto, Satoru Iwasa, Yutaka Saito, Shigeki Sekine

Published in: Virchows Archiv | Issue 5/2019

Abstract

Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesion. We here report a sigmoid colon cancer derived from SuSA, which exhibited aggressive clinical behavior. Endoscopically, the tumor appeared as a superficial elevated lesion with a large nodule. Histological examination of the surgically resected material showed tubular adenocarcinoma associated with SuSA. Although tumor invasion was limited to the submucosal layer, lymph node and extranodal metastases were detected. The patient subsequently developed peritoneal metastases and died 15 months after surgery. Molecular analyses identified a KRAS mutation and a novel PRR15L-RSPO2 fusion, which retains the entire coding region of RSPO2, in both SuSA and adenocarcinoma components. The present study demonstrates the malignant potential of SuSA and expands the spectrum of RSPO fusions in colorectal neoplasms.

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Title: Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma
Authors: Yasuhiko Mizuguchi
Taku Sakamoto
Taiki Hashimoto
Shunsuke Tsukamoto
Satoru Iwasa
Yutaka Saito
Shigeki Sekine
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Metastasis
Colorectal Cancer
Colorectal Cancer
Colon Cancer
Colon Cancer
Published in: Virchows Archiv / Issue 5/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02604-x

At a glance: The STEP trials

Springer Medicine

Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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