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01-07-2019 | Gestational Trophoblastic Disease | Brief Report

Gestational trophoblastic neoplasms (GTNs) do not display epithelial-to-mesenchymal transition (EMT) features

Authors: Estelle Dubruc, Fabienne Allias, Anne Pierre Morel, François Golfier, Alain Puisieux, Mojgan Devouassoux-Shisheboran

Published in: Virchows Archiv | Issue 1/2019

Abstract

Although epithelial-to-mesenchymal transition (EMT) has been described in the development of complete hydatidiform moles and the invasion of the maternal decidua by trophoblasts during normal human placentation, its implication in gestational trophoblastic neoplasm (GTN) without villi is totally unknown. We studied the immunoexpression of EMT transcription factors (TWIST1, ZEB1, ZEB2), E-cadherin, and vimentin in 18 trophoblastic tumors and pseudo-tumors. Weak nuclear TWIST1 immunostaining was seen in 5% to 10% of all trophoblastic cells, without ZEB1 and ZEB2 nuclear staining. Trophoblastic cells did not express vimentin, and the expression of E-cadherin was maintained in all cases, indicating the absence of EMT features in GTN.

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Title: Gestational trophoblastic neoplasms (GTNs) do not display epithelial-to-mesenchymal transition (EMT) features
Authors: Estelle Dubruc
Fabienne Allias
Anne Pierre Morel
François Golfier
Alain Puisieux
Mojgan Devouassoux-Shisheboran
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keyword: Gestational Trophoblastic Disease
Published in: Virchows Archiv / Issue 1/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02551-7

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Gestational trophoblastic neoplasms (GTNs) do not display epithelial-to-mesenchymal transition (EMT) features

Abstract

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