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Virchows Archiv

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01-03-2019 | Letter to the Editor

Intratumoral HER2 heterogeneity in early gastric carcinomas: potential bias in therapeutic management

Authors: Antonio Ieni, Roberta Cardia, Maria Lentini, Giovanni Tuccari

Published in: Virchows Archiv | Issue 3/2019

Excerpt

Dear Editor, …

Kanayama K, Imai H, Usugi E, Shiraishi T, Hirokawa YS, Watanabe M (2018) Association of HER2 gene amplification and tumor progression in early gastric cancer. Virchows Arch 473(5):559–565. https://doi.org/10.1007/s00428-018-2433-y CrossRefPubMed

Yan Y, Lu L, Liu C, Li W, Liu T, Fu W (2015) HER2/neu overexpression predicts poor outcome in early gastric cancer without lymph node metastasis. Clin Res Hepatol Gastroenterol 39(1):121–126. https://doi.org/10.1016/j.clinre.2014.06.019 CrossRefPubMed

Grillo F, Fassan M, Sarocchi F, Fiocca R, Mastracci L (2016) HER2 heterogeneity in gastric/gastroesophageal cancers: from benchside to practice. World J Gastroenterol 22(26):5879–5887. https://doi.org/10.3748/wjg.v22.i26.5879 CrossRefPubMedPubMedCentral

Ieni A, Barresi V, Rigoli L, Caruso RA, Tuccari G (2015) HER2 status in premalignant, early, and advanced neoplastic lesions of the stomach. Dis Markers 2015:234851. https://doi.org/10.1155/2015/234851 CrossRefPubMedPubMedCentral

Ieni A, Barresi V, Caltabiano R, Caleo A, Bonetti LR, Lanzafame S, Zeppa P, Caruso RA, Tuccari G (2014) Discordance rate of HER2 status in primary gastric carcinomas and synchronous lymph node metastases: a multicenter retrospective analysis. Int J Mol Sci 15(12):22331–22341. https://doi.org/10.3390/ijms151222331 CrossRefPubMedPubMedCentral

Title: Intratumoral HER2 heterogeneity in early gastric carcinomas: potential bias in therapeutic management
Authors: Antonio Ieni
Roberta Cardia
Maria Lentini
Giovanni Tuccari
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 3/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2502-2

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Intratumoral HER2 heterogeneity in early gastric carcinomas: potential bias in therapeutic management

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