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01-03-2018 | Brief Report

Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience

Authors: Ehab Y. Hanna, Ahmed S. A. Abdelmeguid, Dianna Roberts, Achim H. Bell, Randal S. Weber, Diana Bell

Published in: Virchows Archiv | Issue 3/2018

Excerpt

Adenoid cystic carcinoma (ACC) is a biphasic salivary gland malignancy that is characterized by cellular, morphologic, and clinical heterogeneity [1]. ACCs are the second most common salivary gland malignancy, are the most common malignancy of minor salivary glands, and comprise 15–25% of all salivary carcinomas. Despite locally aggressive growth with frequent perineural invasion, ACCs demonstrate slow biologic progression and lymph node metastasis is rare [1]. …

Speight PM, Barrett AW (2002) Salivary gland tumours. Oral Dis 8:229–240CrossRefPubMed

Adenoid cystic carcinoma (2017). In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of tumors of the head and neck, 4^th ed. Tumors of salivary glands. Lyon:IARC Press; 164–165

Bell D, Hanna EY (2013) Head and neck adenoid cystic carcinoma: what is new in biological markers and treatment? Curr Opin Otolaryngol Head Neck Surg 21:124–129CrossRefPubMed

Barsky SH, Karlin NJ (2005) Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 10:249–260CrossRefPubMed

Hu M, Yao J, Carroll DK et al (2008) Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 13:394–406CrossRefPubMedPubMedCentral

Bell D, Bell AH, Bondaruk J, Hanna EY, Weber RS (2016) In-depth characterization of the salivary adenoid cystic carcinoma transcriptome with emphasis on dominant cell type. Cancer 122:1513–1522CrossRefPubMed

Bell D, Roberts D, Karpowicz M, Hanna EY, Weber RS, El-Naggar AK (2011) Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. Cancer Biol Ther 12:569–573CrossRefPubMedPubMedCentral

Bell D, Roberts D, Kies M, Rao P, Weber RS, El-Naggar AK (2010) Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer 116:5749–5756CrossRefPubMedPubMedCentral

Lloyd S, JB Y, Wilson LD, Decker RH (2011) Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapy. Am J Clin Oncol 34:76–81CrossRefPubMed

10.

Hu Z, Fan C, DS O et al (2006) The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7:96CrossRefPubMedPubMedCentral

11.

Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752CrossRefPubMed

12.

Prat A, Perou CM (2011) Deconstructing the molecular portraits of breast cancer. Mol Oncol 5:5–23CrossRefPubMed

13.

Raouf A, Zhao Y, To K et al (2008) Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell 3:109–118CrossRefPubMed

14.

Weigelt B, Hu Z, He X et al (2005) Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 65:9155–9158CrossRefPubMed

Title: Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience
Authors: Ehab Y. Hanna
Ahmed S. A. Abdelmeguid
Dianna Roberts
Achim H. Bell
Randal S. Weber
Diana Bell
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 3/2018
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2248-2

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Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients—a single-institution experience

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