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01-07-2017 | Original Article

High neuronatin (NNAT) expression is associated with poor outcome in breast cancer

Authors: Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski

Published in: Virchows Archiv | Issue 1/2017

Abstract

Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3.55, p = 0.002) and overall survival (HR = 6.29, p < 0.001). However, NNAT expression was not associated with classical parameters such as hormone receptor expression (p = 0.86) or lymph node metastasis (p = 0.83). Additional independent risk factors in this study population were tumor size (≤2 cm; overall survival: HR = 0.36, p = 0.023; relapse-free survival: HR = 0.26, p < 0.01) and blood vessel infiltration (overall survival: HR = 0.34 p < 0.01). NNAT expression determined by immunohistochemistry might therefore become a helpful additional biomarker to identify high-risk breast cancer patients.

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Title: High neuronatin (NNAT) expression is associated with poor outcome in breast cancer
Authors: Norbert Nass
Sarah Walter
Dörthe Jechorek
Christine Weissenborn
Atanas Ignatov
Johannes Haybaeck
Saadettin Sel
Thomas Kalinski
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 1/2017
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2154-7

At a glance: The STEP trials

Springer Medicine

High neuronatin (NNAT) expression is associated with poor outcome in breast cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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