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Breast Cancer Research
Published in: Breast Cancer Research 4/2004

01-08-2004 | Review

S100A7 and the progression of breast cancer

Authors: Ethan D Emberley, Leigh C Murphy, Peter H Watson

Published in: Breast Cancer Research | Issue 4/2004

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Abstract

The S100 gene family comprises more than 20 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. The expression of individual family members is not ubiquitous for all tissues and there appears to be an element of tissue-specific expression. Molecular analysis of breast tumors has revealed that several S100s, including S100A2, S100A4 and S100A7, exhibit altered expression levels during breast tumorigenesis and/or progression. Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify. The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer.
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Metadata
Title
S100A7 and the progression of breast cancer
Authors
Ethan D Emberley
Leigh C Murphy
Peter H Watson
Publication date
01-08-2004
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2004
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr816

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