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01-10-2010 | Original Article

Mucin core protein expression in serrated polyps of the large intestine

Authors: Kohei Fujita, Minako Hirahashi, Hidetaka Yamamoto, Takayuki Matsumoto, Masaki Gushima, Yoshinao Oda, Junji Kishimoto, Takashi Yao, Mitsuo Iida, Masazumi Tsuneyoshi

Published in: Virchows Archiv | Issue 4/2010

Abstract

Sessile serrated adenoma (SSA) has been proposed as a precursor to microsatellite-unstable colorectal carcinoma. However, histological criteria dictating how to differentiate serrated lesions have not been completely established, and a histological overlap exists between SSA and hyperplastic polyps (HPs), particularly the microvesicular type. In this study, based on a critical review of histology, we aimed to elucidate the potential utility of the mucin phenotype in the identification of SSA. We evaluated mucin core protein expression (MUC2, MUC5AC, and MUC6) by immunohistochemical stain in 65 cases of microvesicular-type HPs, 51 SSAs, and 72 traditional serrated adenomas (TSAs). SSAs had clinicopathological and morphological features distinct from those of HPs and TSAs. MUC6 was more frequently positive in SSAs (39%) than in TSAs (4%) and HPs (19%) (P < 0.001 and P = 0.0107, respectively). Right-sided HPs more frequently expressed MUC6 than did left-sided HPs (60% vs. 4%, respectively; P < 0.0001), but SSAs and TSAs showed no regional differences. These findings suggest that determination of mucin core protein expression is insufficient for differentiating SSAs from other types of serrated polyps, and that microvesicular-type HPs of the right colon and SSAs may belong to the same mucin spectrum.

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Title: Mucin core protein expression in serrated polyps of the large intestine
Authors: Kohei Fujita
Minako Hirahashi
Hidetaka Yamamoto
Takayuki Matsumoto
Masaki Gushima
Yoshinao Oda
Junji Kishimoto
Takashi Yao
Mitsuo Iida
Masazumi Tsuneyoshi
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2010
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0959-8

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Mucin core protein expression in serrated polyps of the large intestine

Abstract

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