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01-05-2009 | Original Article

Extranodular background liver parenchyma of focal nodular hyperplasia: histopathological characteristics

Authors: Utaroh Motosugi, Shin-ichi Murata, Michio Shimizu, Masanori Yasuda, Takaki Sakurai, Yoshihiko Shimizu, Shinichi Ban, Kohji Nagata, Hiroshi Yamaguchi, Seiya Sannohe

Published in: Virchows Archiv | Issue 5/2009

Abstract

Focal nodular hyperplasia (FNH) of the liver is considered to develop as a hyperplastic response to a preexisting vascular abnormality. From the pathogenic point of view, we studied histological alterations in the extranodular background liver tissue of FNH (FNH-bg-liver). We compared ten FNH-bg-livers with ten non-FNH cases (non-FNH-liver) and found small uniform nodule formations with ring-like siderosis in the FNH-bg-livers (4/7, 57%) but not in the non-FNH-livers. Abnormal small arteries not accompanied by portal tracts were observed in six of six FNH-bg-livers for which immunohistochemical study was available, while this was observed in only three of the ten non-FNH-livers. CD34-positive sinusoids around the portal tracts were observed in only the FNH-bg-livers (3/6, 50%). Further, two of ten FNH-bg-livers had ectopic pancreatic tissue. Ring-like siderosis, abnormal small arteries, CD34-positive sinusoids, and ectopic pancreatic tissue were characteristic in the extranodular background liver tissue in cases of FNH.

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Title: Extranodular background liver parenchyma of focal nodular hyperplasia: histopathological characteristics
Authors: Utaroh Motosugi
Shin-ichi Murata
Michio Shimizu
Masanori Yasuda
Takaki Sakurai
Yoshihiko Shimizu
Shinichi Ban
Kohji Nagata
Hiroshi Yamaguchi
Seiya Sannohe
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2009
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0743-9

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Extranodular background liver parenchyma of focal nodular hyperplasia: histopathological characteristics

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