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01-03-2007 | Original Article

Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer

Authors: Guangying Qi, Ikuko Ogawa, Yasusei Kudo, Mutsumi Miyauchi, B. S. M. S. Siriwardena, Fumio Shimamoto, Masaaki Tatsuka, Takashi Takata

Published in: Virchows Archiv | Issue 3/2007

Abstract

Aurora-B kinase is a chromosomal passenger protein and is essential for chromosome segregation and cytokinesis. Aurora-B overexpression in various cancer cells induces chromosomal number instability to produce multinuclearity and relates to metastasis. Here, we examined the expression of Aurora-B in oral squamous cell carcinoma (OSCC) to elucidate the relationship between Aurora-B expression and clinico-pathological findings by immunohistochemistry. Aurora-B expression was observed in normal oral squamous epithelia and OSCC cases, but the number of positive cells was significantly higher in OSCC than in normal squamous epithelium (p < 0.01). The labeling index of Aurora-B was significantly correlated with lymph node metastasis (p < 0.01) and histological grades of differentiation (p < 0.01). We also compared Aurora-B expression with Ki-67 expression and a positive correlation was found (p < 0.0001). Moreover, Aurora-B expression is significantly more frequent in multinuclear tumor cells than in total tumor cells. In summary, we found that Aurora-B expression was well correlated with cell proliferation, induction of multinuclear cells, histological differentiation, and metastasis in OSCC. These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC.

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Title: Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer
Authors: Guangying Qi
Ikuko Ogawa
Yasusei Kudo
Mutsumi Miyauchi
B. S. M. S. Siriwardena
Fumio Shimamoto
Masaaki Tatsuka
Takashi Takata
Publication date: 01-03-2007
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 3/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0360-9

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Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer

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