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01-10-2005 | Original Article

Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer

Authors: Reiko Ito, Naohide Oue, Kazuhiro Yoshida, Kyoko Kunimitsu, Hirofumi Nakayama, Kei Nakachi, Wataru Yasui

Published in: Virchows Archiv | Issue 4/2005

Abstract

Cadherin-17 (CDH17), also called liver–intestine cadherin, is a structurally unique member of the cadherin superfamily. Our serial analysis of gene expression demonstrated that CDH17 was one of the most up-regulated genes in advanced gastric carcinomas. CDH17 expression is known to be regulated by Cdx2. In the present study, we examined the expression of CDH17 in primary gastric carcinoma tissues by immunohistochemistry, and analyzed the correlation of CDH17 expression with clinicopathological characteristics and patients prognosis. CDH17 expression was detected in 63/94 (67%) of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of CDH17 tended to be associated with intestinal type carcinoma, and carcinomas with CDH17 expression was significantly more frequent in advanced stage cases (80%) than in early stage (53%). The prognosis of patients with positive CDH17 expression was significantly poorer than that of the negative cases (P=0.0314). However, multivariate analysis revealed that CDH17 was not an independent prognostic factor. Six of seven cases that showed positive expression of Cdx2 simultaneously expressed CDH17 protein. These results suggested that the expression of CDH17 was characteristic of the advanced gastric carcinoma that is associated with poor prognosis.

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Title: Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer
Authors: Reiko Ito
Naohide Oue
Kazuhiro Yoshida
Kyoko Kunimitsu
Hirofumi Nakayama
Kei Nakachi
Wataru Yasui
Publication date: 01-10-2005
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2005
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0015-2

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Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer

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