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Published in: Langenbeck's Archives of Surgery 7/2020

Open Access 01-11-2020 | Pancreatic Cancer | How-I-Do-It articles

Cavernous transformation of the portal vein in pancreatic cancer surgery—venous bypass graft first

Authors: Thomas Schmidt, Oliver Strobel, Martin Schneider, Markus K. Diener, Christoph Berchtold, André L. Mihaljevic, Arianeb Mehrabi, Beat P. Müller-Stich, Thilo Hackert, Markus W. Büchler

Published in: Langenbeck's Archives of Surgery | Issue 7/2020

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Abstract

Background

In recent years, several techniques have been introduced to allow safe oncologic resections of cancers of the pancreatic head. While resections of the mesenterico-portal axis became now a part of the routine treatment, patients with a cavernous transformation of the portal vein still pose a surgical challenge and are regularly deemed unresectable.

Objective

Here, we describe a technique of initial venous bypass graft placement between the superior mesenteric vein or its tributaries and the portal vein before the resection of the pancreatic head. This approach avoids uncontrollable bleeding as well as venous congestion of the intestine with a continuous hepatic perfusion and facilitates oncologic resection of pancreatic head cancers. This technique, in combination with previously published resection strategies, enables tumor resection in locally advanced pancreatic head cancers.

Conclusions

Venous bypass graft first operations facilitate and enable the resection of the pancreatic head cancers in patients with a cavernous transformation of the portal vein thus rendering these patients resectable.
Literature
4.
5.
go back to reference Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernandez-Del Castillo C, Ferrone CR, Hong TS (2018) Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial. JAMA Oncol 4(7):963–969. https://doi.org/10.1001/jamaoncol.2018.0329CrossRefPubMedPubMedCentral Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernandez-Del Castillo C, Ferrone CR, Hong TS (2018) Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial. JAMA Oncol 4(7):963–969. https://​doi.​org/​10.​1001/​jamaoncol.​2018.​0329CrossRefPubMedPubMedCentral
6.
go back to reference Versteijne E, Vogel JA, Besselink MG, Busch ORC, Wilmink JW, Daams JG, van Eijck CHJ, Groot Koerkamp B, Rasch CRN, van Tienhoven G, Dutch Pancreatic Cancer G (2018) Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer. Br J Surg 105(8):946–958. https://doi.org/10.1002/bjs.10870CrossRefPubMedPubMedCentral Versteijne E, Vogel JA, Besselink MG, Busch ORC, Wilmink JW, Daams JG, van Eijck CHJ, Groot Koerkamp B, Rasch CRN, van Tienhoven G, Dutch Pancreatic Cancer G (2018) Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer. Br J Surg 105(8):946–958. https://​doi.​org/​10.​1002/​bjs.​10870CrossRefPubMedPubMedCentral
9.
go back to reference Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, Andren-Sandberg A, Asbun HJ, Bassi C, Bockhorn M, Charnley R, Conlon KC, Dervenis C, Fernandez-Cruz L, Friess H, Gouma DJ, Imrie CW, Lillemoe KD, Milicevic MN, Montorsi M, Shrikhande SV, Vashist YK, Izbicki JR, Buchler MW, International Study Group on Pancreatic S (2014) Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery 156(1):1–14. https://doi.org/10.1016/j.surg.2014.02.009CrossRefPubMed Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, Andren-Sandberg A, Asbun HJ, Bassi C, Bockhorn M, Charnley R, Conlon KC, Dervenis C, Fernandez-Cruz L, Friess H, Gouma DJ, Imrie CW, Lillemoe KD, Milicevic MN, Montorsi M, Shrikhande SV, Vashist YK, Izbicki JR, Buchler MW, International Study Group on Pancreatic S (2014) Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery 156(1):1–14. https://​doi.​org/​10.​1016/​j.​surg.​2014.​02.​009CrossRefPubMed
13.
23.
go back to reference Castleberry AW, White RR, De La Fuente SG, Clary BM, Blazer DG 3rd, McCann RL, Pappas TN, Tyler DS, Scarborough JE (2012) The impact of vascular resection on early postoperative outcomes after pancreaticoduodenectomy: an analysis of the American College of Surgeons National Surgical Quality Improvement Program database. Ann Surg Oncol 19(13):4068–4077. https://doi.org/10.1245/s10434-012-2585-yCrossRefPubMed Castleberry AW, White RR, De La Fuente SG, Clary BM, Blazer DG 3rd, McCann RL, Pappas TN, Tyler DS, Scarborough JE (2012) The impact of vascular resection on early postoperative outcomes after pancreaticoduodenectomy: an analysis of the American College of Surgeons National Surgical Quality Improvement Program database. Ann Surg Oncol 19(13):4068–4077. https://​doi.​org/​10.​1245/​s10434-012-2585-yCrossRefPubMed
24.
go back to reference Yekebas EF, Bogoevski D, Cataldegirmen G, Kunze C, Marx A, Vashist YK, Schurr PG, Liebl L, Thieltges S, Gawad KA, Schneider C, Izbicki JR (2008) En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients. Ann Surg 247(2):300–309. https://doi.org/10.1097/SLA.0b013e31815aab22CrossRefPubMed Yekebas EF, Bogoevski D, Cataldegirmen G, Kunze C, Marx A, Vashist YK, Schurr PG, Liebl L, Thieltges S, Gawad KA, Schneider C, Izbicki JR (2008) En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients. Ann Surg 247(2):300–309. https://​doi.​org/​10.​1097/​SLA.​0b013e31815aab22​CrossRefPubMed
26.
go back to reference Kurahara H, Shinchi H, Ohtsuka T, Miyasaka Y, Matsunaga T, Noshiro H, Adachi T, Eguchi S, Imamura N, Nanashima A, Sakamoto K, Nagano H, Ohta M, Inomata M, Chikamoto A, Baba H, Watanabe Y, Nishihara K, Yasunaga M, Okuda K, Natsugoe S, Nakamura M (2019) Significance of neoadjuvant therapy for borderline resectable pancreatic cancer: a multicenter retrospective study. Langenbecks Arch Surg 404(2):167–174. https://doi.org/10.1007/s00423-019-01754-5CrossRefPubMed Kurahara H, Shinchi H, Ohtsuka T, Miyasaka Y, Matsunaga T, Noshiro H, Adachi T, Eguchi S, Imamura N, Nanashima A, Sakamoto K, Nagano H, Ohta M, Inomata M, Chikamoto A, Baba H, Watanabe Y, Nishihara K, Yasunaga M, Okuda K, Natsugoe S, Nakamura M (2019) Significance of neoadjuvant therapy for borderline resectable pancreatic cancer: a multicenter retrospective study. Langenbecks Arch Surg 404(2):167–174. https://​doi.​org/​10.​1007/​s00423-019-01754-5CrossRefPubMed
27.
go back to reference Nakao A, Harada A, Nonami T, Kaneko T, Takagi H (1995) Regional vascular resection using catheter bypass procedure for pancreatic cancer. Hepatogastroenterology 42(5):734–739PubMed Nakao A, Harada A, Nonami T, Kaneko T, Takagi H (1995) Regional vascular resection using catheter bypass procedure for pancreatic cancer. Hepatogastroenterology 42(5):734–739PubMed
30.
go back to reference Conway WC, Bolton JS (2014) Mesocaval shunt to facilitate complex venous resection during pancreaticoduodenectomy. Am Surg 80(11):1179–1181CrossRef Conway WC, Bolton JS (2014) Mesocaval shunt to facilitate complex venous resection during pancreaticoduodenectomy. Am Surg 80(11):1179–1181CrossRef
36.
go back to reference Diener MK, Huttner FJ, Kieser M, Knebel P, Dorr-Harim C, Distler M, Grutzmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Borner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Buchler MW, ChroPac Trial G (2017) Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet 390(10099):1027–1037. https://doi.org/10.1016/S0140-6736(17)31960-8CrossRefPubMed Diener MK, Huttner FJ, Kieser M, Knebel P, Dorr-Harim C, Distler M, Grutzmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Borner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Buchler MW, ChroPac Trial G (2017) Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet 390(10099):1027–1037. https://​doi.​org/​10.​1016/​S0140-6736(17)31960-8CrossRefPubMed
Metadata
Title
Cavernous transformation of the portal vein in pancreatic cancer surgery—venous bypass graft first
Authors
Thomas Schmidt
Oliver Strobel
Martin Schneider
Markus K. Diener
Christoph Berchtold
André L. Mihaljevic
Arianeb Mehrabi
Beat P. Müller-Stich
Thilo Hackert
Markus W. Büchler
Publication date
01-11-2020
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 7/2020
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-020-01974-0

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