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Published in: Langenbeck's Archives of Surgery 8/2014

01-12-2014 | Original Article

Improving the outcome of acute cholecystitis: the non-standardized treatment must no longer be employed

Authors: Juan Ignacio González-Muñoz, María Angoso, José María Sayagués, Ana Belén Sánchez-Casado, Alvaro Hernández, Antonio Velasco, Luís Muñoz-Bellvis

Published in: Langenbeck's Archives of Surgery | Issue 8/2014

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Abstract

Purpose

Therapeutic recommendations of acute cholecystitis are not consistently implemented, which generates greater patient morbidity and higher health care costs. The aim of this article is to evaluate the burden of acute cholecystitis, to detect potentially modifiable variables, and to propose a therapeutic strategy that will allow us to improve the quality of care.

Methods

We carried out a retrospective study of patients who were admitted to the hospital from January 2010 to December 2012 using a univariate analysis of parameters including the admitting department, age, treatment administered, and length of stay.

Results

A total of 967 patients were admitted to the hospital with a diagnosis of acute cholecystitis, 692 (72 %) to the Surgery Department, 257 (26 %) to Internal Medicine-Digestive, and 18 (2 %) to other departments. Four hundred ninety-eight (51.5 %) were operated on: 107 (21 %) on an urgent basis, 111 (22 %) at an early stage (<96 h at diagnosis), 152 (30 %) at a late stage (>96 h at diagnosis), and 128 (26 %) at a delayed date (other admission). Patients who were admitted into the surgery department were five times more likely to be operated on than patients admitted into other departments (p < 0.01). Patients operated on at a late stage had a longer length of stay than early stage surgery patients (p < 0.05) and than non-operated ones (p < 0.05). Patients <74 years old were more frequently operated than older ones (p < 0.05).

Conclusions

The non-standardized treatment of acute cholecystitis causes high clinical and surgical variability, long average stay, more readmissions, and high hospital costs. Therefore, patients with a diagnosis of acute cholecystitis should be admitted to the Surgery Department, thereby increasing the probability of receiving definite treatment.
Literature
3.
go back to reference McSherry CK, Ferstenberg H, Calhown WF et al (1985) Natural history of diagnosed gallstone disease in symptomatic and asymptomatic patients. Ann Surg 202:59–63PubMedCentralPubMedCrossRef McSherry CK, Ferstenberg H, Calhown WF et al (1985) Natural history of diagnosed gallstone disease in symptomatic and asymptomatic patients. Ann Surg 202:59–63PubMedCentralPubMedCrossRef
4.
go back to reference Carter HR, Cox RL, Polk HC Jr (1987) Operative therapy for cholecystitis and cholelithiasis: trends over three decades. Am Surg 53:565PubMed Carter HR, Cox RL, Polk HC Jr (1987) Operative therapy for cholecystitis and cholelithiasis: trends over three decades. Am Surg 53:565PubMed
5.
go back to reference Hickman MS, Schwesinger WH, Page CP (1988) Acute cholecystitis in the diabetic: a case-control study of outcome. Arch Surg 123:409–11PubMedCrossRef Hickman MS, Schwesinger WH, Page CP (1988) Acute cholecystitis in the diabetic: a case-control study of outcome. Arch Surg 123:409–11PubMedCrossRef
6.
go back to reference Halldestam I, Enell EL, Kullman E et al (2004) Development of symptoms and complications in individuals with asymptomatic gallstones. Br J Surg 91:734–8PubMedCrossRef Halldestam I, Enell EL, Kullman E et al (2004) Development of symptoms and complications in individuals with asymptomatic gallstones. Br J Surg 91:734–8PubMedCrossRef
7.
go back to reference Lee HK, Han HS, Min SK (2005) Sex-based analysis of the outcome of laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 92:463–6PubMedCrossRef Lee HK, Han HS, Min SK (2005) Sex-based analysis of the outcome of laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 92:463–6PubMedCrossRef
9.
go back to reference Norrby S, Herlin P, Holmin T et al (1983) Early or delayed cholecystectomy in acute cholecystitis? A clinical trial. Br J Surg 70:163–5PubMedCrossRef Norrby S, Herlin P, Holmin T et al (1983) Early or delayed cholecystectomy in acute cholecystitis? A clinical trial. Br J Surg 70:163–5PubMedCrossRef
10.
go back to reference Overby DW, Apelgren KN, Richardson W et al (2010) SAGES guidelines for the clinical application of laparoscopic biliary tract surgery. Surg Endosc 24:2368–86PubMedCrossRef Overby DW, Apelgren KN, Richardson W et al (2010) SAGES guidelines for the clinical application of laparoscopic biliary tract surgery. Surg Endosc 24:2368–86PubMedCrossRef
11.
go back to reference Takada T, Strasberg S, Solomkin JS et al (2013) Updated Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:1–7PubMedCrossRef Takada T, Strasberg S, Solomkin JS et al (2013) Updated Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:1–7PubMedCrossRef
12.
go back to reference Gutt CN, Encke J, Koninger J et al (2013) Acute cholecystitis. Early versus delayed cholecystectomy. A multicenter randomized trial. (ACDC study, NCT 00447304). Ann Surg 258(3):385–93PubMedCrossRef Gutt CN, Encke J, Koninger J et al (2013) Acute cholecystitis. Early versus delayed cholecystectomy. A multicenter randomized trial. (ACDC study, NCT 00447304). Ann Surg 258(3):385–93PubMedCrossRef
14.
go back to reference 14. Gurusumany KS, Samraj K (2006) Early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Cochrane Database Syst Rev CD005440. 14. Gurusumany KS, Samraj K (2006) Early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Cochrane Database Syst Rev CD005440.
15.
go back to reference Livingstone EH, Rege RV (2004) A nationwide study of conversion from laparoscopic to open cholecystectomy. Am J Surg 188:205–11CrossRef Livingstone EH, Rege RV (2004) A nationwide study of conversion from laparoscopic to open cholecystectomy. Am J Surg 188:205–11CrossRef
16.
go back to reference Casillas R, Yegiyants S, Collins C (2008) Early laparoscopic cholecystectomy is the preferred management of acute cholecystitis. Arch Surg 143(6):533–37PubMedCrossRef Casillas R, Yegiyants S, Collins C (2008) Early laparoscopic cholecystectomy is the preferred management of acute cholecystitis. Arch Surg 143(6):533–37PubMedCrossRef
17.
18.
go back to reference Senapati PS, Bhattarcharya D, Harinath G et al (2003) A survey of timing and approach to the surgical management of cholelithiasis in patients with acute biliary pancreatitis and acute cholecystitis in the UK. Am R Coll Surg Engl 85:306–12CrossRef Senapati PS, Bhattarcharya D, Harinath G et al (2003) A survey of timing and approach to the surgical management of cholelithiasis in patients with acute biliary pancreatitis and acute cholecystitis in the UK. Am R Coll Surg Engl 85:306–12CrossRef
19.
go back to reference Stephens M, Beaton C (2010) Early cholecystectomy after acute admission with cholecystitis: how much work? World J Surg 34:2041–44PubMedCrossRef Stephens M, Beaton C (2010) Early cholecystectomy after acute admission with cholecystitis: how much work? World J Surg 34:2041–44PubMedCrossRef
20.
go back to reference Yamashita Y, Takada T, Hirata K (2006) A Survey of the timing and approach to the surgical management of patients with acute colecystitis in Japanese hospitals. J Hepato-Biliary-Pancreat Surg 13:409–15CrossRef Yamashita Y, Takada T, Hirata K (2006) A Survey of the timing and approach to the surgical management of patients with acute colecystitis in Japanese hospitals. J Hepato-Biliary-Pancreat Surg 13:409–15CrossRef
21.
go back to reference Mestral C, Laupacis A, Rotsein O et al (2013) Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practices. CMAJ open 1(2):E62–7PubMedCentralPubMedCrossRef Mestral C, Laupacis A, Rotsein O et al (2013) Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practices. CMAJ open 1(2):E62–7PubMedCentralPubMedCrossRef
22.
go back to reference Askew J (2005) A survey of the current surgical treatment of gallstones in Queensland. ANZ J Surg 75:1086–9PubMedCrossRef Askew J (2005) A survey of the current surgical treatment of gallstones in Queensland. ANZ J Surg 75:1086–9PubMedCrossRef
23.
go back to reference Barceló M, Cruz-Santamaría D, Alba-López C et al (2013) Advantages of early cholecystectomy in clinical practice of a tertiary care center. Hepatobiliary Pancreat Dis Int 12(1):87–93PubMedCrossRef Barceló M, Cruz-Santamaría D, Alba-López C et al (2013) Advantages of early cholecystectomy in clinical practice of a tertiary care center. Hepatobiliary Pancreat Dis Int 12(1):87–93PubMedCrossRef
24.
go back to reference Germanos S, Gourgiotis S, MKocher H (2007) Clinical update: early surgery for acute cholecystitis. Lancet 369:1774–6PubMedCrossRef Germanos S, Gourgiotis S, MKocher H (2007) Clinical update: early surgery for acute cholecystitis. Lancet 369:1774–6PubMedCrossRef
25.
go back to reference De Mestral C, Rotsein O, Laupa A et al (2014) Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis. Ann Surg 259(1):10–7PubMedCrossRef De Mestral C, Rotsein O, Laupa A et al (2014) Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis. Ann Surg 259(1):10–7PubMedCrossRef
26.
go back to reference Greenwald JA, McMullen HF, Coppa GF et al (2000) Standardization of surgeon-controlled variables. Impact on outcome in patients with acute cholecystitis. Ann Surg 231(3):339–44PubMedCentralPubMedCrossRef Greenwald JA, McMullen HF, Coppa GF et al (2000) Standardization of surgeon-controlled variables. Impact on outcome in patients with acute cholecystitis. Ann Surg 231(3):339–44PubMedCentralPubMedCrossRef
27.
go back to reference Hadad SM, Vaidya JS, Baker L et al (2007) Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. World J Surg 31:1298–1301PubMedCrossRef Hadad SM, Vaidya JS, Baker L et al (2007) Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. World J Surg 31:1298–1301PubMedCrossRef
28.
go back to reference The burden of gastrointestinal diseases. Bethesda, MD. American gastrointestinal Association, 2001. The burden of gastrointestinal diseases. Bethesda, MD. American gastrointestinal Association, 2001.
29.
go back to reference Wilson E, Gurusamy K, Gluud C et al (2010) Cost-utility and value-of-information analysis of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 97:210–9PubMedCrossRef Wilson E, Gurusamy K, Gluud C et al (2010) Cost-utility and value-of-information analysis of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 97:210–9PubMedCrossRef
30.
go back to reference Macafee DAL, Humes DJ, Bouliotis G (2009) Prospective randomized trial using cost-utility analysis of early versus delayed laparoscopic cholecystectomy for acute gallbladder disease. Br J Surg 96:1031–40PubMedCrossRef Macafee DAL, Humes DJ, Bouliotis G (2009) Prospective randomized trial using cost-utility analysis of early versus delayed laparoscopic cholecystectomy for acute gallbladder disease. Br J Surg 96:1031–40PubMedCrossRef
31.
go back to reference Johner A, Raymakers A, Wiserman SM (2013) Cost utility of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Surg Endosc 27:256–62PubMedCrossRef Johner A, Raymakers A, Wiserman SM (2013) Cost utility of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Surg Endosc 27:256–62PubMedCrossRef
32.
go back to reference Clasificación internacional de enfermedades 9ª revisión modificación clínica. CIE · 9 · MC 8ª edición, enero 2012. (The International Classification of Diseases, 9th Revision, Clinical Modification. 1978, Commission on Professional and Hospital Activities, Ann Arbor, Michigan 48705). Editado por el Ministerio de Sanidad, Política Social e Igualdad, Secretaría General Técnica. © Ministerio de Sanidad, Política Social e Igualdad. Gobierno de España. ISBN: 978–84–7670–715–9. NIPO papel: 860–11–264–7. Depósito legal: M-45671–2011. Clasificación internacional de enfermedades 9ª revisión modificación clínica. CIE · 9 · MC 8ª edición, enero 2012. (The International Classification of Diseases, 9th Revision, Clinical Modification. 1978, Commission on Professional and Hospital Activities, Ann Arbor, Michigan 48705). Editado por el Ministerio de Sanidad, Política Social e Igualdad, Secretaría General Técnica. © Ministerio de Sanidad, Política Social e Igualdad. Gobierno de España. ISBN: 978–84–7670–715–9. NIPO papel: 860–11–264–7. Depósito legal: M-45671–2011.
33.
go back to reference Evolución y proyección de la esperanza de vida al nacer 1992–2011. Tablas de mortalidad de la población de España. Parámetros de evolución demográfica. Instituto Nacional de Estadística (INE). (National Institute of Statistics. Spain). Evolución y proyección de la esperanza de vida al nacer 1992–2011. Tablas de mortalidad de la población de España. Parámetros de evolución demográfica. Instituto Nacional de Estadística (INE). (National Institute of Statistics. Spain).
34.
go back to reference Yokoe M, Takada T, Strasberg SM et al (2013) TG13 diagnostic criteria and severity grading of acute cholecystitis. J Hepatobiliary Pancreat Sci 20:35–46PubMedCrossRef Yokoe M, Takada T, Strasberg SM et al (2013) TG13 diagnostic criteria and severity grading of acute cholecystitis. J Hepatobiliary Pancreat Sci 20:35–46PubMedCrossRef
35.
go back to reference Tsuyuguchi T, Itoi T, Takada T et al (2013) TG13 indications and techniques for gallbladder drainage in acute cholecystitis. J Hepatobiliary Pancreat Sci 20:81–88PubMedCrossRef Tsuyuguchi T, Itoi T, Takada T et al (2013) TG13 indications and techniques for gallbladder drainage in acute cholecystitis. J Hepatobiliary Pancreat Sci 20:81–88PubMedCrossRef
36.
go back to reference Miura F, Takada T, Strasberg SM et al (2013) TG13 flowcharts for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:47–54PubMedCrossRef Miura F, Takada T, Strasberg SM et al (2013) TG13 flowcharts for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:47–54PubMedCrossRef
37.
go back to reference Okamoto K, Takada T, Strasberg SM et al (2013) TG13 management bundles for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:55–59PubMedCrossRef Okamoto K, Takada T, Strasberg SM et al (2013) TG13 management bundles for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 20:55–59PubMedCrossRef
38.
go back to reference Zakko S, Afdhal N. Vollmer C (2012) Treatment of acute cholecystitis. UpToDate, sep Zakko S, Afdhal N. Vollmer C (2012) Treatment of acute cholecystitis. UpToDate, sep
39.
go back to reference Hatzidakis AA, Prassopoulos P, Petinarakis I et al (2002) Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol 12:1778–84PubMedCrossRef Hatzidakis AA, Prassopoulos P, Petinarakis I et al (2002) Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol 12:1778–84PubMedCrossRef
40.
go back to reference Degrate L, Ciravegna AL, Luperto M et al (2013) Acute colecystitis: the Golden 72 hs period is not a strict limit to perform early cholecystectomy. Results from 316 consecutive patients. Langenbecks Arch Surg 398(8):1129–36PubMedCrossRef Degrate L, Ciravegna AL, Luperto M et al (2013) Acute colecystitis: the Golden 72 hs period is not a strict limit to perform early cholecystectomy. Results from 316 consecutive patients. Langenbecks Arch Surg 398(8):1129–36PubMedCrossRef
41.
go back to reference Gurusumany KS, Rossi M., Davidson BR (2013) Percutaneous cholecystostomy for high-risk surgical patients with acute calculous cholecystitis. Cochrane Database Syst Rv Aug 12;8:CD007088. Gurusumany KS, Rossi M., Davidson BR (2013) Percutaneous cholecystostomy for high-risk surgical patients with acute calculous cholecystitis. Cochrane Database Syst Rv Aug 12;8:CD007088.
42.
go back to reference Abi-Haidar Y, Sánchez V, Williams S et al (2012) Revisiting percutaneous cholecystostomy for acute cholecystitis based on a 10-year experience. Arch Surg 147(5):416–422PubMedCrossRef Abi-Haidar Y, Sánchez V, Williams S et al (2012) Revisiting percutaneous cholecystostomy for acute cholecystitis based on a 10-year experience. Arch Surg 147(5):416–422PubMedCrossRef
43.
go back to reference Kortmam K, van Ramshorst B, Bollen T et al (2012) Acute cholecystitis in high risk surgical patients: percutaneous cholecystostomy versus laparoscopic cholecystostomy (CHOCOLATE trial): study protocol for a randomized controlled trial. Trials 13:7CrossRef Kortmam K, van Ramshorst B, Bollen T et al (2012) Acute cholecystitis in high risk surgical patients: percutaneous cholecystostomy versus laparoscopic cholecystostomy (CHOCOLATE trial): study protocol for a randomized controlled trial. Trials 13:7CrossRef
44.
go back to reference Yamashita Y, Takada T, Kawarada Y et al (2007) Surgical treatment of patients with acute colecistitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg 14:91–97PubMedCentralPubMedCrossRef Yamashita Y, Takada T, Kawarada Y et al (2007) Surgical treatment of patients with acute colecistitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg 14:91–97PubMedCentralPubMedCrossRef
45.
go back to reference Kiviluoto T, Siren J, Luukkonen P et al (1998) Randomized trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet 351:321–5PubMedCrossRef Kiviluoto T, Siren J, Luukkonen P et al (1998) Randomized trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet 351:321–5PubMedCrossRef
Metadata
Title
Improving the outcome of acute cholecystitis: the non-standardized treatment must no longer be employed
Authors
Juan Ignacio González-Muñoz
María Angoso
José María Sayagués
Ana Belén Sánchez-Casado
Alvaro Hernández
Antonio Velasco
Luís Muñoz-Bellvis
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 8/2014
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-014-1245-z

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