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01-12-2013 | Review Article

IPMN: surgical treatment

Authors: Reto M. Käppeli, Sascha A. Müller, Bianka Hummel, Christina Kruse, Philip Müller, Jürgen Fornaro, Alexander Wilhelm, Marcel Zadnikar, Bruno M. Schmied, Ignazio Tarantino

Published in: Langenbeck's Archives of Surgery | Issue 8/2013

Abstract

Purpose

Cystic pancreatic tumors are being detected more frequently, and particularly, intraductal papillary mucinous neoplasia (IPMN) has recently attracted increased attention. The detection rate of IPMN has increased over the last decade; however, management of this neoplasm remains controversial.

Methods

Based on a review of the relevant literature and the international guidelines, we discuss the diagnostic evaluation of IPMN, its treatment, and prognosis.

Results

While IPMN represents only a distinct minority of all pancreatic cancers, they appear to be a relatively frequent neoplastic form of pancreatic cystic neoplasm. It may not be possible to differentiate main duct disease from branch duct disease (MD-IPMN vs. BD-IPMN) prior to surgery. This distinction has not only an impact on treatment but also on prognosis, as MD-IPMN is more often malignant. IPMN has updated consensus guideline indications for conservative and surgical resection.

Conclusions

Since patients with IPMN of the pancreas are at risk of developing recurrent IPMN and pancreatic ductal adenocarcinoma in the remnant pancreas and extrapancreatic malignancies, early recognition, treatment, and systemic surveillance are of great importance. No conclusions can be drawn from the available evidence with respect to the efficacy of surveillance and follow-up treatment programs. A better understanding of the natural course of IPMN and the biology of pancreatic cancer is mandatory to enable further diagnostic and treatment improvements.

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Title: IPMN: surgical treatment
Authors: Reto M. Käppeli
Sascha A. Müller
Bianka Hummel
Christina Kruse
Philip Müller
Jürgen Fornaro
Alexander Wilhelm
Marcel Zadnikar
Bruno M. Schmied
Ignazio Tarantino
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 8/2013
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-013-1106-1

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Springer Medicine

IPMN: surgical treatment

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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