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01-12-2012 | Original Article

Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity

Authors: Johan Friso Lock, Maciej Malinowski, Daniel Seehofer, Steffi Hoppe, Rhea Isabel Röhl, Stefan Markus Niehues, Peter Neuhaus, Martin Stockmann

Published in: Langenbeck's Archives of Surgery | Issue 8/2012

Abstract

Background

The regenerative capacity of the liver is an essential pre-condition for the successful application of partial hepatectomy. However, the actual kinetics of functional recovery remains unspecified and no adequate tool for its clinical monitoring has yet been available.

Methods

Eighty-five patients receiving major hepatectomy were investigated from the preoperative evaluation until 12 weeks after surgery. Liver function was determined by the LiMAx test for the enzymatic capacity of cytochrome P450 1A2. Liver volume was determined by volumetric analysis of repeated computer tomography scans. Functional and volume recovery were compared during follow-up.

Results

Major hepatectomy decreased liver function capacity to 35.7 ± 13.8 % of preoperative function. It was shown that functional recovery already reaches 77.2 ± 33.5 % of preoperative values within 10 days. The actual kinetics were dependent from the type and extent of hepatectomy. Complete functional restoration was achieved within 12 weeks, while liver volume still remained at 73.2 ± 14.8 % of preoperative. A constant but interindividually variable correlation between function and volume was observed at all points in time.

Conclusion

Partial hepatectomy leads to fast and complete functional recovery, while volume recovery is delayed and remains often incomplete. The functional recovery is mainly influenced by the preoperative liver function, the residual liver volume, and by obesity.

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Title: Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity
Authors: Johan Friso Lock
Maciej Malinowski
Daniel Seehofer
Steffi Hoppe
Rhea Isabel Röhl
Stefan Markus Niehues
Peter Neuhaus
Martin Stockmann
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 8/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-012-0972-2

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Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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