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Published in: Langenbeck's Archives of Surgery 6/2012

01-08-2012 | Original Article

Outcomes and prognostic factors in gallbladder cancer: a single-centre experience

Authors: Katharina Cziupka, Lars Ivo Partecke, Lutz Mirow, Claus-Dieter Heidecke, Christian Emde, Wolfgang Hoffmann, Ulrike Siewert, Neeltje van den Berg, Wolfram von Bernstorff, Albrecht Stier

Published in: Langenbeck's Archives of Surgery | Issue 6/2012

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Abstract

Introduction

Gallbladder cancer is the most common malignant tumour of the biliary system with an extraordinarily poor prognosis. In this study, we retrospectively evaluated forty-two patients with histologically proven gallbladder cancer.

Patients and methods

Estimated survival rates were calculated by the Kaplan–Meier method, and differences were assessed using the logrank test. The GKR (combined registry of cancer) and demographic data were used to gain information on community cancer statistics.

Results

In this study, patients with metastases showed poorer survival rates. Furthermore, the survival was significantly better in patients with R0 resections, smaller tumour sizes and without lymph node infiltration. T stage, M stage and R stage were independent prognostic parameters. Sex and age had no significant effect on survival. Also, we found that patients with incidental gallbladder cancer and those with cholecystolithiasis showed significantly better survival rates. Demographic analyses of the study group confirmed a high coverage of our institution for incident cases in our catchment area and no significant regional deviations from the expected incidence of gallbladder cancer.

Conclusion

Despite differences in the incidence in different geographical areas, gallbladder cancer appears to be fairly normally distributed in Western Pomerania, a predominantly rural area of Northeastern Germany. Coverage of incident cases in our catchment area was high. T stage, M stage and R stage were independent prognostic factors in our study. We conclude that, whenever possible, an R0 resection should be the surgical goal in all patients staged resectable before surgery, but heroic resections in patients with highly advanced cancer disease or severe accompanying non-tumour diseases are not warranted.
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Metadata
Title
Outcomes and prognostic factors in gallbladder cancer: a single-centre experience
Authors
Katharina Cziupka
Lars Ivo Partecke
Lutz Mirow
Claus-Dieter Heidecke
Christian Emde
Wolfgang Hoffmann
Ulrike Siewert
Neeltje van den Berg
Wolfram von Bernstorff
Albrecht Stier
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 6/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-012-0950-8

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