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01-04-2012 | Review Article

Immune responses triggering colitis and colitis-associated carcinoma

Authors: Rebecca Kesselring, Stefan Fichtner-Feigl

Published in: Langenbeck's Archives of Surgery | Issue 4/2012

Abstract

Inflammatory bowel diseases compromise of two forms of chronic intestinal inflammatory disorders: Crohn's disease and ulcerative colitis. Both forms of inflammatory bowel disease result from inappropriate inflammatory responses to the intestinal microbiota, but have different underlying immune responses. The connection between inflammation and cancer has long been established and longstanding inflammatory bowel diseases are an important risk factor for developing colorectal cancer. Colitis-associated colorectal cancer pathogenesis is highly influenced by specific inflammatory processes during inflammatory bowel disease. This article reviews the immunological responses affecting Crohn's disease and ulcerative colitis as well as the linkage of inflammatory bowel disease to the development of colitis-associated cancer. Finally, we discuss the prospects of using new research efforts to devise new immunotherapeutic approaches.

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Title: Immune responses triggering colitis and colitis-associated carcinoma
Authors: Rebecca Kesselring
Stefan Fichtner-Feigl
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 4/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-012-0927-7

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Immune responses triggering colitis and colitis-associated carcinoma

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