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Published in: Langenbeck's Archives of Surgery 3/2008

01-05-2008 | How to do it

Living donor liver resection: A low-tech but highly efficient technique. The Regensburg experience

Authors: Aiman Obed, Andreas A. Schnitzbauer, Tung-Yu Tsui, Hani Abu Gosh, Anwar Jarrad, Abdulla Bashir, Hans J. Schlitt

Published in: Langenbeck's Archives of Surgery | Issue 3/2008

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Abstract

Background

To evaluate a low-tech blunt liver dissecting technique for living-liver-donor procedures. Thirty three adult-to-adult living-donor operations were performed at Regensburg University and Jordan Hospital, Amman.

Patients and methods

For the technique of parenchymal dissection, dissecting scissors were used for blunt preparation; branches were closed, carefully pressing into the hepatic parenchyma. Donor, surgical procedure data, and data on liver function and recovery were analyzed and compared to literature.

Results

Median procedure time was 280 min (210 to 420 min). Median blood loss was 350 ml (0 to 650 ml). GOT levels decreased from 260 U/l (140 to 510 U/l) on day 1 to 65 U/l (31 to 220 U/l) on day 7. Bilirubin levels were at 2.0 mmol/l (1.29 to 5.99 mmol/l) on day 1 and 1.26 mmol/l (0.63 to 4.70 mmol/l) on day 7. After 12 days (6 to 23), all donors were discharged. There was no donor mortality. One major complication (biliary leakage) and seven minor complications occurred.

Conclusion

This technique is a low-tech but efficient donor-dissection technique in living liver transplantation, which is comparable to other well established dissection techniques utilizing technical devices in regards to risk for the donor, performance, and recovery.
Literature
1.
go back to reference Deutsche Stiftung für Organtransplantation (2007) Organspende und transplantation 2006. DSO 2007, Neu-Isenburg Deutsche Stiftung für Organtransplantation (2007) Organspende und transplantation 2006. DSO 2007, Neu-Isenburg
2.
go back to reference Bismuth H, Castaing D, Garden OJ (1988) Segmental surgery of the liver. Surg Annu 20:291–310PubMed Bismuth H, Castaing D, Garden OJ (1988) Segmental surgery of the liver. Surg Annu 20:291–310PubMed
3.
go back to reference Bismuth H, Houssin D, Michel F (1983) Operative risk in hepatectomies. Experience with 154 hepatectomies.109(4):342–348PubMed Bismuth H, Houssin D, Michel F (1983) Operative risk in hepatectomies. Experience with 154 hepatectomies.109(4):342–348PubMed
4.
go back to reference Rau HG, Schauer R, Pickelmann S, Beyer BC, Angele MK, Zimmermann A, Meimarakis G, Heizmann O, Schildberg FW (2001) Dissection techniques in liver surgery. Chirurg 72(2):105–112PubMedCrossRef Rau HG, Schauer R, Pickelmann S, Beyer BC, Angele MK, Zimmermann A, Meimarakis G, Heizmann O, Schildberg FW (2001) Dissection techniques in liver surgery. Chirurg 72(2):105–112PubMedCrossRef
5.
go back to reference Lesurtel M, Selzner M, Petrowsky H, McCormack L, Clavien PA (2005) How should transection of the liver be performed?: a prospective randomized study in 100 consecutive patients: comparing four different transection strategies. Ann Surg 242(6):814–822PubMedCrossRef Lesurtel M, Selzner M, Petrowsky H, McCormack L, Clavien PA (2005) How should transection of the liver be performed?: a prospective randomized study in 100 consecutive patients: comparing four different transection strategies. Ann Surg 242(6):814–822PubMedCrossRef
6.
go back to reference Yamamoto Y, Ikai I, Kume M, Sakai Y, Yamauchi A, Shinohara H, Morimoto T, Shimahara Y, Yamamoto M, Yamaoka Y (1999) New simple technique for hepatic parenchymal resection using a Cavitron Ultrasonic Surgical Aspirator and bipolar cautery equipped with a channel for water dripping. World J Surg 23(10):1032–1037PubMedCrossRef Yamamoto Y, Ikai I, Kume M, Sakai Y, Yamauchi A, Shinohara H, Morimoto T, Shimahara Y, Yamamoto M, Yamaoka Y (1999) New simple technique for hepatic parenchymal resection using a Cavitron Ultrasonic Surgical Aspirator and bipolar cautery equipped with a channel for water dripping. World J Surg 23(10):1032–1037PubMedCrossRef
7.
go back to reference Marcos A (2000) Right-lobe living donor liver transplantation. Liver Transpl 6(6 Suppl 2):S59–S63PubMedCrossRef Marcos A (2000) Right-lobe living donor liver transplantation. Liver Transpl 6(6 Suppl 2):S59–S63PubMedCrossRef
8.
go back to reference Lo CM, Fan ST, Liu CL, Yong BH, Wong Y, Lau GK, Lai CL, Ng IO, Wong J (2004) Lessons learned from one hundred right lobe living donor liver transplants. Ann Surg 240(1):151–158PubMedCrossRef Lo CM, Fan ST, Liu CL, Yong BH, Wong Y, Lau GK, Lai CL, Ng IO, Wong J (2004) Lessons learned from one hundred right lobe living donor liver transplants. Ann Surg 240(1):151–158PubMedCrossRef
9.
go back to reference Fan ST, Lo CM, Liu CL (2000) Technical refinement in adult-to-adult living donor liver transplantation using right lobe graft. Ann Surg 231(1):126–131PubMedCrossRef Fan ST, Lo CM, Liu CL (2000) Technical refinement in adult-to-adult living donor liver transplantation using right lobe graft. Ann Surg 231(1):126–131PubMedCrossRef
10.
go back to reference Fujita S, Kim ID, Uryuhara K, Asonuma K, Egawa H, Kiuchi T, Hayashi M, Uemeto S, Inomata Y, Tanaka K (2000) Hepatic grafts from live donors: donor morbidity for 470 cases of live donation. Transpl Int 13(5):333–339PubMedCrossRef Fujita S, Kim ID, Uryuhara K, Asonuma K, Egawa H, Kiuchi T, Hayashi M, Uemeto S, Inomata Y, Tanaka K (2000) Hepatic grafts from live donors: donor morbidity for 470 cases of live donation. Transpl Int 13(5):333–339PubMedCrossRef
11.
go back to reference Grewal HP, Thistlewaite JR Jr, Loss GE, Fisher JS, Cronin DC, Siegel CT, Newell KA, Bruce DS, Woodle ES, Brady L, Kelly S, Boone P, Oswald K, Millis JM (1998) Complications in 100 living-liver donors. Ann Surg 228(2):214–219PubMedCrossRef Grewal HP, Thistlewaite JR Jr, Loss GE, Fisher JS, Cronin DC, Siegel CT, Newell KA, Bruce DS, Woodle ES, Brady L, Kelly S, Boone P, Oswald K, Millis JM (1998) Complications in 100 living-liver donors. Ann Surg 228(2):214–219PubMedCrossRef
12.
go back to reference de Villa VH, Chen CL, Chen YS, Wang CC, Lin CC, Cheng YF, Huang TL, Jawan B, Eng HL (2003) Right lobe living donor liver transplantation-addressing the middle hepatic vein controversy. Ann Surg 238(2):275–282PubMed de Villa VH, Chen CL, Chen YS, Wang CC, Lin CC, Cheng YF, Huang TL, Jawan B, Eng HL (2003) Right lobe living donor liver transplantation-addressing the middle hepatic vein controversy. Ann Surg 238(2):275–282PubMed
13.
go back to reference Shah SA, Grant DR, Greig PD, McGilvray ID, Adcock LD, Girgrah N, Wong P, Kim RD, Smith R, Lilly LB, Levy GA, Cattral MS (2005) Analysis and outcomes of right lobe hepatectomy in 101 consecutive living donors. Am J Transplant 5(11):2764–2769PubMedCrossRef Shah SA, Grant DR, Greig PD, McGilvray ID, Adcock LD, Girgrah N, Wong P, Kim RD, Smith R, Lilly LB, Levy GA, Cattral MS (2005) Analysis and outcomes of right lobe hepatectomy in 101 consecutive living donors. Am J Transplant 5(11):2764–2769PubMedCrossRef
14.
go back to reference Malago M, Testa G, Frilling A, Nadalin S, Valentin-Gamazo C, Paul A, Lang H, Treichel U, Cicinnati V, Gerken G, Broelsch CE (2003) Right living donor liver transplantation: an option for adult patients: single institution experience with 74 patients. Ann Surg 238(6):853–862PubMedCrossRef Malago M, Testa G, Frilling A, Nadalin S, Valentin-Gamazo C, Paul A, Lang H, Treichel U, Cicinnati V, Gerken G, Broelsch CE (2003) Right living donor liver transplantation: an option for adult patients: single institution experience with 74 patients. Ann Surg 238(6):853–862PubMedCrossRef
15.
go back to reference Broering DC, Wilms C, Bok P, Fischer L, Mueller L, Hillert C, Lenk C, Kim JS, Sterneck M, Schulz KH, Krupski G, Nierhaus A, Ameis D, Burdelski M, Rogiers X (2004) Evolution of donor morbidity in living related liver transplantation: a single-center analysis of 165 cases. Ann Surg 240(6):1013–1024PubMedCrossRef Broering DC, Wilms C, Bok P, Fischer L, Mueller L, Hillert C, Lenk C, Kim JS, Sterneck M, Schulz KH, Krupski G, Nierhaus A, Ameis D, Burdelski M, Rogiers X (2004) Evolution of donor morbidity in living related liver transplantation: a single-center analysis of 165 cases. Ann Surg 240(6):1013–1024PubMedCrossRef
16.
go back to reference Lo CM, Fan ST, Liu CL, Wei WI, Lo RJ, Lai CL, Chan JK, Ng IO, Fung A, Wong J (1997) Adult-to-adult living donor liver transplantation using extended right lobe grafts. Ann Surg 226(3):261–269PubMedCrossRef Lo CM, Fan ST, Liu CL, Wei WI, Lo RJ, Lai CL, Chan JK, Ng IO, Fung A, Wong J (1997) Adult-to-adult living donor liver transplantation using extended right lobe grafts. Ann Surg 226(3):261–269PubMedCrossRef
17.
go back to reference Nadalin S, Malagò M, Radtke A, Erim Y, Saner F, Valentin-Gamazo C, Schröder T, Schaffer R, Sotiropoulos GC, Li J, Frilling A, Broelsch CE (2007) Current trends in live liver donation. Transpl Int 20:312–330PubMedCrossRef Nadalin S, Malagò M, Radtke A, Erim Y, Saner F, Valentin-Gamazo C, Schröder T, Schaffer R, Sotiropoulos GC, Li J, Frilling A, Broelsch CE (2007) Current trends in live liver donation. Transpl Int 20:312–330PubMedCrossRef
18.
go back to reference Une Y, Uchino J, Horie T, Sato Y, Ogasawara K, Kakita A, Sano F (1989) Liver resection using a water jet. Cancer Chemother Pharmacol 23:S74–S77 (Suppl)PubMedCrossRef Une Y, Uchino J, Horie T, Sato Y, Ogasawara K, Kakita A, Sano F (1989) Liver resection using a water jet. Cancer Chemother Pharmacol 23:S74–S77 (Suppl)PubMedCrossRef
19.
go back to reference Obed A, Schnitzbauer AA, Bein T, Lehn N, Linde HJ, Schlitt HJ (2006) Fatal pneumonia caused by Panton-Valentine Leucocidine-positive methicillin-resistant Staphylococcus aureus (PVL-MRSA) transmitted from a healthy donor in living-donor liver transplantation. Transplantation 81(1):121–124PubMedCrossRef Obed A, Schnitzbauer AA, Bein T, Lehn N, Linde HJ, Schlitt HJ (2006) Fatal pneumonia caused by Panton-Valentine Leucocidine-positive methicillin-resistant Staphylococcus aureus (PVL-MRSA) transmitted from a healthy donor in living-donor liver transplantation. Transplantation 81(1):121–124PubMedCrossRef
20.
go back to reference Trotter JF, Campsen J, Bak T, Wachs M, Forman L, Everson G, Kam I (2006) Outcomes of donor evaluations for adult-to-adult right hepatic lobe living donor liver transplantation. Am J Transplant 6(8):1882–1889PubMedCrossRef Trotter JF, Campsen J, Bak T, Wachs M, Forman L, Everson G, Kam I (2006) Outcomes of donor evaluations for adult-to-adult right hepatic lobe living donor liver transplantation. Am J Transplant 6(8):1882–1889PubMedCrossRef
21.
go back to reference Broelsch CE, Whitington PF, Emond JC, Heffron TG, Thistlethwaite JR, Stevens L, Piper J, Whitington SH, Lichtor JL (1991) Liver transplantation in children from living related donors. Surgical techniques and results. Ann Surg 214(4):428–437PubMedCrossRef Broelsch CE, Whitington PF, Emond JC, Heffron TG, Thistlethwaite JR, Stevens L, Piper J, Whitington SH, Lichtor JL (1991) Liver transplantation in children from living related donors. Surgical techniques and results. Ann Surg 214(4):428–437PubMedCrossRef
22.
go back to reference Liu CL, Fan ST (2006) Adult-to-adult live-donor liver transplantation: the current status. J Hepatobiliary Pancreat Surg 13(2):110–116PubMedCrossRef Liu CL, Fan ST (2006) Adult-to-adult live-donor liver transplantation: the current status. J Hepatobiliary Pancreat Surg 13(2):110–116PubMedCrossRef
23.
go back to reference Middleton PF, Duffield M, Lynch SV, Padbury RT, House T, Stanton P, Verran D, Maddern G (2006) Living donor liver transplantation–adult donor outcomes: a systematic review. Liver Transpl 12(1):24–30PubMedCrossRef Middleton PF, Duffield M, Lynch SV, Padbury RT, House T, Stanton P, Verran D, Maddern G (2006) Living donor liver transplantation–adult donor outcomes: a systematic review. Liver Transpl 12(1):24–30PubMedCrossRef
Metadata
Title
Living donor liver resection: A low-tech but highly efficient technique. The Regensburg experience
Authors
Aiman Obed
Andreas A. Schnitzbauer
Tung-Yu Tsui
Hani Abu Gosh
Anwar Jarrad
Abdulla Bashir
Hans J. Schlitt
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 3/2008
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-007-0261-7

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