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European Journal of Applied Physiology

Published in:

01-09-2016 | Original Article

Strenuous physical exercise accelerates the lipid peroxide clearing transport by HDL

Authors: Iiro A. Välimäki, Timo Vuorimaa, Markku Ahotupa, Tommi J. Vasankari

Published in: European Journal of Applied Physiology | Issue 9/2016

Abstract

Purpose

Physical exercise has cardioprotective functions, which have been partly linked to high-density lipoprotein (HDL), and its functions. We studied the effects of endogenous oxidative stress, induced by acute exhaustive physical exercise, on concentration of oxidized HDL lipids.

Methods

Twenty-four male national top-level endurance runners, 12 middle-distance runners and 12 marathon runners performed a maximal run on a treadmill until exhaustion. We analyzed concentrations of oxidized HDL (oxHDLlipids) and LDL lipids (oxLDLlipids), serum antioxidant potential (TRAP), paraoxonase activity and malondialdehyde. Venous blood samples were taken before, immediately, 15 and 90 min after exercise.

Results

Immediately after the treadmill run the concentration of oxHDLlipids was increased by 24 % (p < 0.01). Simultaneously, the ratio of oxHDLlipids to oxLDLlipids increased by 55 % and the oxLDLlipids levels decreased by 19 % (p < 0.001), while serum malondialdehyde and TRAP increased by 54 % (p < 0.001) and 29 % (p < 0.01), respectively. After the 90 min recovery the concentration of oxHDLlipids was decreased towards the pre-exercise level, but that of oxLDLlipids remained decreased below pre-exercise values (p < 0.001). The change in oxLDLlipids after the run correlated positively with VO_2max (r = 0.67, p < 0.001) and negatively with the change in paraoxonase activity (r = −0.47, p < 0.05).

Conclusions

We conclude that acute exhaustive physical exercise increased the concentration of oxHDLlipids and decreased that of oxLDLlipids and the ratio of oxLDLlipids to oxHDLlipids, which suggests that during physical exercise HDL has an active role in the removal of lipid peroxides.

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Title: Strenuous physical exercise accelerates the lipid peroxide clearing transport by HDL
Authors: Iiro A. Välimäki
Timo Vuorimaa
Markku Ahotupa
Tommi J. Vasankari
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3422-y

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Strenuous physical exercise accelerates the lipid peroxide clearing transport by HDL

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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