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01-04-2016 | Original Article

Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults

Authors: Kazuya Ishida, Takeshi Nakamura, Kenichi Kimura, Nami Kanno, Noriyo Takahashi, Yoshi-ichiro Kamijo, Fumihiro Tajima

Published in: European Journal of Applied Physiology | Issue 4/2016

Abstract

Purpose

While non-noxious local cooling is widely used in physical medicine, its effect on muscle sympathetic nerve activity (MSNA) and cardiovascular regulation are not clear. The purpose of the present study was to assess the responses of MSNA, blood pressure (BP), heart rate (HR) and local blood flow during non-noxious local cooling.

Methods

The study included two protocols. Both protocols consisted of 10-min rest in supine position, followed by 15-min local cooling (15 °C) of the shin and anterior foot, and 20-min recovery. MSNA of the right common peroneal nerve, BP, HR, and shin skin temperature (TSK) were recorded in eight men in the first protocol, while leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography in the second protocol.

Results

TSK gradually decreased from 31.5 ± 0.02 to 16.0 ± 1.01 °C (mean ± SEM) during local cooling, and gradually increased after the end of local cooling. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate increased significantly (p < 0.05) to 141.1 ± 12.5 % during local cooling, but decreased significantly (p < 0.05) to 73.6 ± 5.9 % during the recovery period. Total MSNA also increased to 148.0 ± 14.2 % (p < 0.05) during local cooling, and decreased to 74.0 ± 13.9 % (p < 0.05) at recovery. LBF remained constant through the experiment.

Conclusions

The results suggest that MSNA is activated by non-noxious local cooling, and attenuated after the end of local cooling without any changes in HR and BP.

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Title: Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults
Authors: Kazuya Ishida
Takeshi Nakamura
Kenichi Kimura
Nami Kanno
Noriyo Takahashi
Yoshi-ichiro Kamijo
Fumihiro Tajima
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 4/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3343-9

At a glance: The STEP trials

Springer Medicine

Suppression of activation of muscle sympathetic nerve during non-noxious local cooling after the end of local cooling in normal adults

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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