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01-09-2013 | Original Article

Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury

Authors: Melissa Lynn Erickson, Terence E. Ryan, Hui-Ju Young, Kevin K. McCully

Published in: European Journal of Applied Physiology | Issue 9/2013

Abstract

After spinal cord injury (SCI) skeletal muscle decreases in size, increases in intramuscular fat, and has potential declines in mitochondrial function. Reduced mitochondrial function has been linked to the development of metabolic disease. The aim of this study was to measure mitochondrial function in persons with SCI using near-infrared spectroscopy (NIRS). Oxygen consumption of the vastus lateralis muscle was measured with NIRS during repeated short-duration arterial occlusions in nine able-bodied (AB) and nine persons with motor complete SCI. Skeletal muscle oxidative capacity (V _max) was evaluated with two approaches: (1) rate constant of the recovery of oxygen consumption after exercise and (2) extrapolated maximum oxygen consumption from a progressive work test. V _max as indicated by the rate constant (k) from the recovery kinetics test was lower in SCI compared with AB participants (k: SCI 0.7 ± 0.3 vs. AB 1.9 ± 0.4 min⁻¹; p < 0.001). Time constants were SCI 91.9 ± 37.8 vs. AB 33.6 ± 8.3 s. V _max from the progressive work test approached a significant difference between groups (SCI 5.1 ± 2.9 vs. AB 9.8 ± 5.5 % Hb-Mb/s; p = 0.06). NIRS measurements of V _max suggest a deficit of 50–60 % in participants with SCI compared with AB controls, consistent with previous studies using ³¹P-MRS and muscle biopsies. NIRS measurements can assess mitochondrial capacity in people with SCI and potentially other injured/diseased populations.

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Title: Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury
Authors: Melissa Lynn Erickson
Terence E. Ryan
Hui-Ju Young
Kevin K. McCully
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2013
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-013-2657-0

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Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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