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01-03-2010 | Original Article

Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity

Authors: Reinaldo Abunasser Bassit, Carlos Hermano da Justa Pinheiro, Kaio Fernando Vitzel, Antônio José Sproesser, Leonardo R. Silveira, Rui Curi

Published in: European Journal of Applied Physiology | Issue 5/2010

Abstract

The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal muscles was investigated. Eight Ironman triathletes were randomized into the placebo (Pl; n = 4) and creatine-supplemented (CrS; n = 4) groups. Five days prior to the Ironman competition, the CrS group received creatine monohydrate (20 g day⁻¹) plus maltodextrin (50 g) divided in two equal doses. The Pl group received maltodextrin (50 g day⁻¹) only. The effect of CrS (5 g day⁻¹/kg body weight for 5 days) was also evaluated in a protocol of strenuous contractile activity induced by electrical stimulation in rats. Blood samples were collected before and 36 and 60 h after the competition and were used to determine plasma activities of creatine kinase (CK), lactate dehydrogenase (LDH), aldolase (ALD), glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), and C-reactive protein (CRP) level. In rats, plasma activities of CK and LDH, muscle vascular permeability (MVP) using Evans blue dye, muscle force and fatigue were evaluated. Activities of CK, ALD, LDH, GOT, GTP, and levels of CRP were increased in the Pl group after the competition as compared to basal values. CrS decreased plasma activities of CK, LDH, and ALD, and prevented the rise of GOT and GPT plasma activities. In rats, CrS delayed the fatigue, preserved the force, and prevented the rise of LDH and CK plasma activities and MVP in the gastrocnemius muscle. CrS presented a protective effect on muscle injury induced by strenuous contractile activities.

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Title: Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity
Authors: Reinaldo Abunasser Bassit
Carlos Hermano da Justa Pinheiro
Kaio Fernando Vitzel
Antônio José Sproesser
Leonardo R. Silveira
Rui Curi
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 5/2010
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-009-1305-1

At a glance: The STEP trials

Springer Medicine

Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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