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01-04-2007 | Original Article

Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men

Authors: Weili Zhu, Chongfa Zhong, Yingjie Yu, Keji Li

Published in: European Journal of Applied Physiology | Issue 6/2007

Abstract

Post-prandial hyperglycaemia impairs endothelial function as evaluated by brachial artery flow-mediated dilation (FMD). Exercise is an intervention to protect against cardiovascular disease and to improve FMD. In this study, we examined whether the effect of acute hyperglycaemia on endothelial function in healthy young men is restored by aerobic exercise. Using a counterbalanced, randomized crossover design, we measured the brachial artery FMD at baseline and 1, 2, 3 and 4 h after 75 g glucose ingestion in 11 healthy young men, with and without a single bout of aerobic exercise. Brachial artery FMD declined from 11.4 ± 3.8% at baseline to 7.3 ± 3.4% 1 h after oral glucose ingestion, and returned to baseline after 4 h. When the oral glucose ingestion was followed immediately by 45 min of treadmill exercise at an intensity of 60% maximal oxygen uptake, FMD demonstrated no significant decrease (11.8 ± 2.5, 11.3 ± 2.8, 12.2 ± 2.7, 13.5 ± 3.5, and 12.6 ± 2.4% at baseline and 4 h after ingestion, respectively). The results indicate that the aerobic exercise restores the impaired FMD induced by oral glucose ingestion.

Akbari CM, Saouaf R, Barnhill DF, Newman PA, LoGerfo FW, Veves A (1998) Endothelium-dependent vasodilatation is impaired in both microcirculation and macrocirculation during acute hyperglycemia. J Vasc Surg 28:687–694PubMedCrossRef

Asakawa T, Matsushita S (1979) Thiobarbituric acid test for detecting lipid peroxides. Lipids 14:401–406CrossRef

Ceriello A (1998) The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications. Diabet Med 15:188–193PubMedCrossRef

Ceriello A, Bortolotti N, Crescentini A, Motz E, Lizzio S, Russo A, Ezsol Z, Tonutti L, Taboga C (1998) Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects. Eur J Clin Invest 28:329–333PubMedCrossRef

Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, Da Ros R, Motz E (2002) Evidence for an independent and cumulative effect of post-prandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation 106:1211–1218PubMedCrossRef

Chowienczyk PJ, Watts GF, Cockcroft JR, Ritter JM (1992) Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia. Lancet 340:1430–1432PubMedCrossRef

Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force. J Am Coll Cardiol 39:257–265PubMedCrossRef

Cosentino F, Hishikawa K, Katusic ZS, Luscher TF (1997) High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 96:25–28PubMed

Dickinson S, Brand-Miller J (2005) Glycemic index, post-prandial glycemia and cardiovascular disease. Curr Opin Lipidol 16:69–75PubMedCrossRef

Feener EP, King GL (1997) Vascular dysfunction in diabetes mellitus. Lancet 350:9–13CrossRef

Fisslthaler B, Dimmeler S, Hermann C, Busse R, Fleming I (2000) Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand 168:81–88PubMedCrossRef

Giugliano D, Marfella R, Coppola L, Verrazzo G, Acampora R, Giunta R, Nappo F, Lucarelli C, D’Onofrio F (1997) Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 95:1783–1790PubMed

Gori T, Harvey P, Floras JS, Parker JD (2004) Continuous therapy with nitroglycerin impairs endothelium-dependent vasodilation but does not cause tolerance in conductance arteries: a human in vivo study. J Cardiovasc Pharmacol 44:601–606PubMedCrossRef

Graier WF, Simecek S, Kukovetz WR, Kostner GM (1996) High d-glucose-induced changes in endothelial Ca21/EDRF signaling are due to generation of superoxide anions. Diabetes 45:1386–1395PubMedCrossRef

Gryglewski RJ, Palmer RM, Moncada S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320:454–456PubMedCrossRef

Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107:3152–3158PubMedCrossRef

Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G (2000) Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 342:454–460PubMedCrossRef

Harvey PJ, Morris BL, Kubo T, Picton PE, Su WS, Notarius CF, Floras JS (2005a) Hemodynamic after-effects of acute dynamic exercise in sedentary normotensive postmenopausal women. J Hypertens 23:285–292CrossRef

Harvey PJ, Picton PE, Su WS, Morris BL, Notarius CF, Floras JS (2005b) Exercise as an alternative to oral estrogen for amelioration of endothelial dysfunction in postmenopausal women. Am Heart J 149:291–297CrossRef

Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, Sagara Y, Taketani Y, Orimo H, Ouchi Y (1995) Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation 92:3431–3435PubMed

Heinecke JW (2003) Oxidative stress: new approaches to diagnosis and prognosis in atherosclerosis. Am J Cardiol 91:12A–16APubMedCrossRef

Higashi Y, Sasaki S, Sasaki N, Nakagawa K, Ueda T, Yoshimizu A, Kurisu S, Matsuura H, Kajiyama G, Oshima T (1999) Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension. Hypertension 33:591–597PubMed

Ihlemann N, Rask-Madsen C, Perner A, Dominguez H, Hermann T, Kober L, Torp-Pedersen C (2003) Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. Am J Physiol Heart Circ Physiol 285: H875–H882PubMed

Jain SK, Palmer M, Chen Y (1999) Effect of vitamin E and N-acetylcysteine on phosphatidylserine externalization and induction of coagulation by high-glucose-treated human erythrocytes. Metabolism 48:957–959PubMedCrossRef

Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314–1319PubMed

Jungersten L, Ambring A, Wall B, Wennmalm A (1997) Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol 82:760–764PubMedCrossRef

Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H (1999) Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 34:146–154PubMedCrossRef

Kingwell BA, Sherrard B, Jennings GL, Dart AM (1997) Four weeks of cycle training increases basal production of nitric oxide from the forearm. Am J Physiol 272: H1070–H1077PubMed

Konukoglu D, Hatemi H, Ozer E, Gonen S, Akcay T (1997) The erythrocyte glutathione levels during oral glucose tolerance test. J Endocrinol Invest 20:471–475PubMed

Lefebvre PJ, Scheen AJ (1998) The postprandial state and risk of cardiovascular disease. Diabet Med 15: S63–S68PubMedCrossRef

Ma SW, Tomlinson B, Benzie IF (2005) A study of the effect of oral glucose loading on plasma oxidant:antioxidant balance in normal subjects. Eur J Nutr 44:250–254PubMedCrossRef

Maiorana A, O’Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C, Taylor R, Green D (2001) The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38:860–866PubMedCrossRef

Marsh SA, Coombes JS (2005) Exercise and the endothelial cell. Int J Cardiol 99:165–169PubMedCrossRef

Node K, Kitakaze M, Sato H, Koretsune Y, Katsube Y, Karita M, Kosaka H, Hori M (1997) Effect of acute dynamic exercise on circulating plasma nitric oxide level and correlation to norepinephrine release in normal subjects. Am J Cardiol 79:526–528PubMedCrossRef

Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP (2006) The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98:256–262PubMedCrossRef

Ross R (1986) The pathogenesis of atherosclerosis-an update. N Engl J Med 314:488–500PubMedCrossRef

Rubanyi GM, Vanhoutte PM (1986) Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am J physiol 250: H815–H821PubMed

Siafarikas A, Watts K, Beye P, Jones TW, Davis EA, Green DJ (2004) Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects. Clin Sci (Lond) 107:191–196CrossRef

Tanriverdi H, Evrengul H, Tanriverdi S, Turgut S, Akdag B, Kaftan HA, Semiz E (2005) Improved endothelium dependent vasodilation in endurance athletes and its relation with ACE I/D polymorphism. Circ J 69:1105–1110PubMedCrossRef

Tesfamariam B, Cohen RA (1992) Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 263:H321–H326PubMed

Title LM, Cummings PM, Giddens K, Nassar BA (2000) Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J Am Coll Cardiol 36:2185–2191PubMedCrossRef

Treasure CB, Klein JL, Vita JA, Manoukian SV, Renwick GH, Selwyn AP, Ganz P, Alexander RW (1993) Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels. Circulation 87:86–93PubMed

Walsh JH, Bilsborough W, Maiorana A, Best M, O’Driscoll GJ, Taylor RR, Green DJ (2003) Exercise training improves conduit vessel function in patients with coronary artery disease. J Appl Physiol 95:20–25PubMed

Walther C, Gielen S, Hambrecht R (2004) The effect of exercise training on endothelial function in cardiovascular disease in humans. Exerc Sport Sci Rev 32:129–134PubMedCrossRef

Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, Creager MA (1998) Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97:1695–1701PubMed

Title: Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men
Authors: Weili Zhu
Chongfa Zhong
Yingjie Yu
Keji Li
Publication date: 01-04-2007
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 6/2007
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-006-0378-3

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Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men

Abstract

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