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International Archives of Occupational and Environmental Health

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01-08-2021 | Hypertension | Review Article

Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis

Authors: Mojtaba Davoudi, Fateme Barjasteh-Askari, Mohammad Sarmadi, Mohammad Ghorbani, Mehdi Yaseri, Edris Bazrafshan, Amir Hossein Mahvi, Mohsen Moohebati

Published in: International Archives of Occupational and Environmental Health | Issue 6/2021

Abstract

Background and objective

Previous studies showed controversial results of the relationship between fluoride exposure through drinking water and elevated blood pressure. We conducted a systematic review and meta-analysis to assess the direct relationship of drinking water fluoride exposure with blood pressure and essential hypertension prevalence in general populations.

Methods

We conducted a systematic search in databases including Web of Knowledge, PubMed, Scopus, and Embase by MeSH and non-MeSH terms for relevant studies with any design published until August 2019, with no limitation in time and language. The pooled effect measure was calculated within a 95% confidence interval (CI).

Results

Our search retrieved 630 journal articles, six of which were eligible for data extraction. The random-effects model found significantly higher systolic blood pressure (mean difference = 6.49 mmHg; 95% CI 3.73–9.25; p value < 0.01) and diastolic blood pressure (mean difference = 4.33 mmHg; 95% CI 1.39–7.26; p value < 0.01) in groups exposed to high-fluoride drinking water than in groups exposed to normal/low-fluoride drinking water. A significant relationship was also found between high-fluoride drinking water and essential hypertension (odds ratio = 2.14; 95% CI 1.02–4.49; p value = 0.045).

Conclusion

The risk of elevated blood pressure increases in the general population of fluoride endemic areas. However, more research is needed to make a firm conclusion about the adverse effects of excess fluoride intake on the cardiovascular system at the individual level.

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Title: Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis
Authors: Mojtaba Davoudi
Fateme Barjasteh-Askari
Mohammad Sarmadi
Mohammad Ghorbani
Mehdi Yaseri
Edris Bazrafshan
Amir Hossein Mahvi
Mohsen Moohebati
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hypertension
Hypertension
Published in: International Archives of Occupational and Environmental Health / Issue 6/2021
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-021-01714-x

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Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis

Abstract

Background and objective

Methods

Results

Conclusion

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Abstract

Background and objective

Methods

Results

Conclusion

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