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International Archives of Occupational and Environmental Health

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01-04-2019 | Tremor | Original Article

Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease

Authors: Dag G. Ellingsen, Grigoriy Shvartsman, Rita Bast-Pettersen, Maxim Chashchin, Yngvar Thomassen, Valery Chashchin

Published in: International Archives of Occupational and Environmental Health | Issue 3/2019

Abstract

Purpose

There is a lack of knowledge about neurobehavioral performance among patients with manganism and how their performance differs from that of idiopathic Parkinson disease patients (PD). This study was initiated with the aim to describe and compare neurobehavioral performance among patients diagnosed with manganism, PD and a group of referents.

Materials and methods

Neurobehavioral performance was assessed in 34 patients diagnosed with manganism, 13 with PD, and 43 healthy workers (turners/fitters) who served as the reference group. Seventeen of the manganism patients had also been tested approximately 65 months previously.

Results

Manganism patients scored substantially more poorly than referents on tests for motor speed, manual dexterity and balance. They also performed more poorly than the PD patients on the postural sway test. In contrast, the PD patients had higher postural tremor intensity with narrower frequency dispersion than manganism patients. The pattern of neurobehavioral performance was more asymmetrical in PD compared to manganism patients, in particular when testing for tremor intestity, grooved pegboard and static steadiness, indicating lateralized impairment in the PD patients. The amount of bradykinesia was comparable between the patient groups. Neurobehavioral performance deteriorated slightly among 17 manganism patients followed for 65 months compared with the age-related decline among referents.

Conclusions

Patients with manganism had severe bradykinesia and balance disturbances, but only slight postural tremor. In contrast, PD patients had significant postural tremor and bradykinesia, but only slight balance disturbances. Their neurobehavioral performance indicated lateralized impairment, more unilateral. Neurobehavioral performance deteriorated slightly in manganism patients during a 65-month follow-up.

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Title: Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease
Authors: Dag G. Ellingsen
Grigoriy Shvartsman
Rita Bast-Pettersen
Maxim Chashchin
Yngvar Thomassen
Valery Chashchin
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keywords: Tremor
Parkinson's Disease
Published in: International Archives of Occupational and Environmental Health / Issue 3/2019
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-019-01415-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease

Abstract

Purpose

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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