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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-04-2021 | Angiography | Retinal Disorders

Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

Authors: Thomas J. van Rijssen, Elon H. C. van Dijk, Paula Scholz, Robert E. MacLaren, Sascha Fauser, Susan M. Downes, Carel B. Hoyng, Camiel J. F. Boon

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2021

Abstract

Purpose

To evaluate the clinical outcomes after half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (cCSC) patients with pre-existent fovea-involving atrophy.

Methods

In this retrospective study, cCSC patients who had a window defect of the retinal pigment epithelium (RPE) on fluorescein angiography (FA), compatible with RPE atrophy, prior to half-dose PDT were included.

Results

Thirty-four cCSC eyes with typical findings of cCSC on multimodal imaging, and fovea-involving RPE atrophy on FA, were included. At the first visit after PDT (at a median of 1.8 months after half-dose PDT), 20 eyes (59%) had a complete resolution of SRF (p < 0.001), while this was the case in 19 eyes (56%) at final visit (median of 11.3 months after half-dose PDT; p < 0.001). The mean BCVA in Early Treatment of Diabetic Retinopathy Study letters was 71. 2 ± 15.9 at last visit before PDT, which increased to 74.1 ± 14.1 at first visit after PDT (p = 0.093, compared with baseline), and changed to 73.0 ± 19.1 at final visit (p = 0.392, compared with baseline). Both at first visit after PDT and at final visit, a significant decrease in subfoveal choroidal thickness was observed (p = 0.032 and p = 0.004, respectively).

Conclusions

Half-dose PDT in cCSC patients with pre-existing fovea-involving atrophy may lead to anatomical changes, but not to functional improvements. Ideally, cCSC should be treated with half-dose PDT before the occurrence of such atrophy.

Gass JD (1967) Pathogenesis of disciform detachment of the neuroepithelium: II. Idiopathic central serous choroidopathy. Am J Ophthalmol 63(3):587/515–615/543. https://doi.org/10.1016/0002-9394(67)90027-XCrossRef

Haimovici R, Koh S, Gagnon DR, Lehrfeld T, Wellik S (2004) Risk factors for central serous chorioretinopathy: a case-control study. Ophthalmology 111(2):244–249. https://doi.org/10.1016/j.ophtha.2003.09.024CrossRefPubMed

Sakurada Y, Fragiotta S, Leong BCS, Parikh R, Hussnain SA, Freund KB (2019) Relationship between choroidal vascular hyperpermeability, choriocapillaris flow density, and choroidal thickness in eyes with pachychoroid pigment epitheliopathy. Retina (Philadelphia, Pa). doi:https://doi.org/10.1097/IAE.0000000000002635

Singh SR, Matet A, van Dijk EHC, Daruich A, Fauser S, Yzer S, Peiretti E, Sivaprasad S, Lotery AJ, Boon CJF, Behar-Cohen F, Freund KB, Chhablani J (2018) Discrepancy in current central serous chorioretinopathy classification. Br J Ophthalmol 103(6):737–742. https://doi.org/10.1136/bjophthalmol-2018-312435CrossRefPubMed

Mrejen S, Balaratnasingam C, Kaden TR, Bottini A, Dansingani K, Bhavsar KV, Yannuzzi NA, Patel S, Chen KC, Yu S, Stoffels G, Spaide RF, Freund KB, Yannuzzi LA (2019) Long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy. Ophthalmology 126(4):576–588. https://doi.org/10.1016/j.ophtha.2018.12.048CrossRefPubMed

Breukink MB, Dingemans AJ, den Hollander AI, Keunen JE, MacLaren RE, Fauser S, Querques G, Hoyng CB, Downes SM, Boon CJ (2017) Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life. Clinical ophthalmology (Auckland, NZ) 11:39-46. https://doi.org/10.2147/OPTH.S115685

van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Blanco-Garavito R, Souied EH, MacLaren RE, Querques G, Fauser S, Hoyng CB, Downes SM, Boon CJF (2019) Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 257(7):1419–1425. https://doi.org/10.1007/s00417-019-04333-yCrossRefPubMed

van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Blanco-Garavito R, Souied EH, Keunen JEE, MacLaren RE, Querques G, Fauser S, Downes SM, Hoyng CB, Boon CJF (2019) Focal and diffuse chronic central serous chorioretinopathy treated with half-dose photodynamic therapy or subthreshold micropulse laser: PLACE trial report no. 3. Am J Ophthalmol 205:1–10. https://doi.org/10.1016/j.ajo.2019.03.025CrossRefPubMed

Mohabati D, van Dijk EH, van Rijssen TJ, de Jong EK, Breukink MB, Martinez-Ciriano JP, Dijkman G, Hoyng CB, Fauser S, Yzer S, Boon CJ (2018) Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clinical ophthalmology (Auckland, NZ) 12:2167–2176. https://doi.org/10.2147/opth.S174573CrossRef

10.

Mohabati D, Hoyng CB, Yzer S, Boon CJF (2019) Clinical characteristics and outcome of posterior cystoid macular degeneration in chronic central serous chorioretinopathy. Retina (Philadelphia, Pa). https://doi.org/10.1097/iae.0000000000002683

11.

van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S, Hoyng CB, Piccolino FC, Chhablani JK, Lai TYY, Lotery AJ, Larsen M, Holz FG, Freund KB, Yannuzzi LA, Boon CJF (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770. https://doi.org/10.1016/j.preteyeres.2019.07.003CrossRefPubMed

12.

Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82–118. https://doi.org/10.1016/j.preteyeres.2015.05.003CrossRefPubMed

13.

van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, Peters PJH, Dijkman G, Souied EH, MacLaren RE, Querques G, Downes SM, Hoyng CB, Boon CJF (2018) Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: the PLACE trial. Ophthalmology 125(10):1547–1555. https://doi.org/10.1016/j.ophtha.2018.04.021CrossRefPubMed

14.

Wang MS, Sander B, Larsen M (2002) Retinal atrophy in idiopathic central serous chorioretinopathy. Am J Ophthalmol 133(6):787–793. https://doi.org/10.1016/s0002-9394(02)01438-1CrossRefPubMed

15.

Imamura Y, Fujiwara T, Spaide RF (2011) Fundus autofluorescence and visual acuity in central serous chorioretinopathy. Ophthalmology 118(4):700–705. https://doi.org/10.1016/j.ophtha.2010.08.017CrossRefPubMed

16.

van Rijssen TJ, Mohabati D, Dijkman G, Theelen T, de Jong EK, van Dijk EHC, Boon CJF (2018) Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy. PLoS One 13(8):e0202549. https://doi.org/10.1371/journal.pone.0202549CrossRefPubMedPubMedCentral

17.

Cardillo Piccolino F, de la Longrais RR, Ravera G, Eandi CM, Ventre L, Abdollahi A, Manea M (2005) The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol 139(1):87–99. https://doi.org/10.1016/j.ajo.2004.08.037CrossRef

18.

Wang JS, Kefalov VJ (2011) The cone-specific visual cycle. Prog Retin Eye Res 30(2):115–128. https://doi.org/10.1016/j.preteyeres.2010.11.001CrossRefPubMed

19.

Fujita K, Imamura Y, Shinoda K, Matsumoto CS, Mizutani Y, Hashizume K, Mizota A, Yuzawa M (2015) One-year outcomes with half-dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy. Ophthalmology 122(3):555–561. https://doi.org/10.1016/j.ophtha.2014.09.034CrossRefPubMed

20.

Lai FH, Ng DS, Bakthavatsalam M, Chan VC, Young AL, Luk FO, Tsang CW, Brelen ME (2016) A multicenter study on the long-term outcomes of half-dose photodynamic therapy in chronic central serous chorioretinopathy. Am J Ophthalmol 170:91–99. https://doi.org/10.1016/j.ajo.2016.07.026CrossRefPubMed

21.

Lim JI, Glassman AR, Aiello LP, Chakravarthy U, Flaxel CJ, Spaide RF (2014) Collaborative retrospective macula society study of photodynamic therapy for chronic central serous chorioretinopathy. Ophthalmology 121(5):1073–1078. https://doi.org/10.1016/j.ophtha.2013.11.040CrossRefPubMed

22.

van Rijssen TJ, van Dijk EHC, Dijkman G, Boon CJF (2018) Clinical characteristics of chronic central serous chorioretinopathy patients with insufficient response to reduced-settings photodynamic therapy. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 256(8):1395–1402. https://doi.org/10.1007/s00417-018-4003-zCrossRefPubMed

Title: Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy
Authors: Thomas J. van Rijssen
Elon H. C. van Dijk
Paula Scholz
Robert E. MacLaren
Sascha Fauser
Susan M. Downes
Carel B. Hoyng
Camiel J. F. Boon
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Keywords: Angiography
Photodynamic Therapy
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04959-3

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Springer Medicine

Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

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Abstract

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Conclusions

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