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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-06-2020 | Glaucoma | Glaucoma

Diagnostic power of scleral spur length in primary open-angle glaucoma

Authors: Mu Li, Zhaoxia Luo, Xiaoqin Yan, Hong Zhang

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2020

Abstract

Purpose

To investigate the diagnostic capability of scleral spur length in discriminating eyes with primary open-angle glaucoma (POAG) from healthy eyes.

Methods

Seventy-eight eyes of 78 patients with POAG and 93 eyes of 93 age-, sex- and axial length-matched healthy subjects were included. The scleral spur length was measured using swept-source optical coherence tomography. Receiver operating characteristic (ROC) curves were derived based on the measurements.

Results

The scleral spur length was significantly shorter in POAG eyes compared with healthy eyes (Method I, 164.91 ± 23.36 vs. 197.60 ± 25.32 μm; Method II, 145.15 ± 16.59 vs. 166.95 ± 19.31 μm; Method III, 162.33 ± 22.83 vs. 185.12 ± 23.58 μm, respectively; all p < 0.001). The areas under ROC curves were 0.841 (Method I), 0.810 (Method II), and 0.753 (Method III) for the scleral spur length. Moreover, Schlemm’s canal area was significantly associated with the scleral spur length (Method I) in both POAG (β = 0.027; p < 0.001) and healthy (β = 0.016; p = 0.009) groups.

Conclusions

The scleral spur length had a good discriminating capability between POAG and healthy eyes, and it could be a novel biomarker for POAG evaluation clinically.

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Title: Diagnostic power of scleral spur length in primary open-angle glaucoma
Authors: Mu Li
Zhaoxia Luo
Xiaoqin Yan
Hong Zhang
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Glaucoma
Refractive Errors
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04637-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Diagnostic power of scleral spur length in primary open-angle glaucoma

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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