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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2020 | Glaucoma | Glaucoma

Short-term effects of caffeine intake on anterior chamber angle and intraocular pressure in low caffeine consumers

Authors: Beatríz Redondo, Jesús Vera, Rubén Molina, Raimundo Jiménez

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2020

Abstract

Background

Acute caffeine consumption causes a transient increase in IOP; however, the mechanisms underlying this phenomenon remain unknown. This study aims to determine the structural changes in cornea and anterior chamber associated with caffeine ingestion.

Methods

Seventeen healthy low caffeine consumers ingested a capsule of caffeine (~ 4 mg/kg) or placebo (300 mg of corn-starch) in a counterbalanced manner. We measured IOP by rebound tonometry and the anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) and central corneal thickness (CCT) with the Pentacam rotating Scheimpflug camera. Subjective feelings of arousal were also obtained. All the dependent variables were obtained before and 30, 60 and 90 min after caffeine/placebo intake.

Results

Caffeine intake caused an acute IOP rise (p = 0.005, η² = 0.403) and a narrowing ACA (p = 0.028, η² = 0.266). However, our data did not reveal any effect on CCT, ACD and ACV after caffeine ingestion (p = 0.798, p = 0.346, p = 0.175, respectively). Participants reported greater levels of activation after ingesting caffeine in comparison to placebo (p = 0.037, η² = 0.245).

Conclusion

The IOP rise associated with caffeine intake may be caused by an ACA reduction, which may add resistance to the outflow of aqueous humour. The current results may be of special relevance for subjects at high risk for glaucoma onset or progression and may help to understand the mechanisms underlying caffeine-induced ocular hypertension.

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Title: Short-term effects of caffeine intake on anterior chamber angle and intraocular pressure in low caffeine consumers
Authors: Beatríz Redondo
Jesús Vera
Rubén Molina
Raimundo Jiménez
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keyword: Glaucoma
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04556-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Short-term effects of caffeine intake on anterior chamber angle and intraocular pressure in low caffeine consumers

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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