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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2019

Open Access 01-11-2019 | Glaucoma | Glaucoma

Changes in spectral parameters of corneal pulse following canaloplasty

Authors: Monika E. Danielewska, Aleksandra K. Kicińska, Michał M. Placek, Katarzyna Lewczuk, Marek Rękas

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2019

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Abstract

Purpose

To ascertain whether changes in the spectral content of the corneal pulse (CP) signal, measured in vivo in primary open-angle glaucoma (POAG) patients, indirectly reflect changes in corneal biomechanics after canaloplasty.

Methods

Fifteen eyes of 15 POAG patients who underwent canaloplasty combined with phacoemulsification were enrolled. Standard ophthalmic examinations were conducted before washout, pre-operatively, at days 1, 7, and 1, 3, 6, and 12 months after surgery. Non-contact measurements of the CP signal were performed at pre-washout, pre-operatively, and at 3, 6, and 12 months post-operatively. Then, amplitudes of the CP first five harmonics associated with the heart rate were estimated. Temporal changes of all considered parameters were tested at a Bonferroni-adjusted significance level set to 0.005.

Results

A decrease in the amplitude of the first harmonic and an increase in the normalized amplitude of the third harmonic (ACP3n) of the CP signal were noticed between the pre-washout and the pre-operative stages (p = 0.003 and p = 0.004, respectively). This corresponds to an increase in median intraocular pressure (IOP) values by 6.0 mmHg (p = 0.0045). After surgery, ACP3n reached the highest value at 3 months post-operatively, compared with pre-washout level (p = 0.0045).

Conclusions

Alterations in corneoscleral stiffness caused by surgery are reflected in changes in the ACP3n value. Hence, post-operative corneal biomechanics could be monitored indirectly by this supporting indicator that can be used to estimate the time at which measures of IOP are no longer biased by the changed cornea boundary conditions caused by canaloplasty.

Clinical Trials Registration

NCT02908633
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Metadata
Title
Changes in spectral parameters of corneal pulse following canaloplasty
Authors
Monika E. Danielewska
Aleksandra K. Kicińska
Michał M. Placek
Katarzyna Lewczuk
Marek Rękas
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Keyword
Glaucoma
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04433-9

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