Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 6/2018

Open Access 01-06-2018 | Retinal Disorders

Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy

Authors: Ling Chen, Xiongze Zhang, Feng Wen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2018

Login to get access

Abstract

Purpose

To determine whether venous beading (VB) in two or more quadrants is an appropriate grading criterion for severe nonproliferative diabetic retinopathy (NPDR).

Methods

A hospital-based, retrospective, cross-sectional study. A total of 806 patients admitted with diabetic retinopathy (DR) from January 2014 to April 2017 were included in this study. DR severity was graded by the international grading criterion. The status of VB, intraretinal microvascular abnormalities (IRMA), capillary nonperfusion, arteriovenous nicking, and diabetic macular edema was evaluated based on fundus fluorescein angiography.

Results

The prevalence of VB in eyes with proliferative diabetic retinopathy (PDR), severe NPDR, and moderate NPDR was 41.3% (327/791), 5.9% (31/526), and 0% (0/295), respectively (p < 0.001). Moreover, the proportion of VB in two or more quadrants was even lower (27.1% for PDR and 2.1% for severe NPDR, p < 0.001), and among the total of 225 eyes with VB in two or more quadrants, 214 eyes (95.1%) were graded as PDR. Furthermore, VB formation was significantly correlated with capillary nonperfusion, duration of diabetes (both p < 0.001), and smoking (p < 0.05). After adjusting for age, sex, and other possible factors, VB (OR = 7.479, p < 0.001) and IRMA (OR = 2.433, p < 0.001) were determined as independent risk factors for developing PDR.

Conclusions

Our study suggested that VB in two or more quadrants might not be a sensitive grading criterion for severe NPDR among a Chinese population with type 2 diabetes. Nevertheless, VB has a great specificity to define an advanced form of DR.
Literature
1.
2.
Yang WY, Lu JM, Weng JP et al (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362(12):1090–1101CrossRefPubMed
3.
Unnikrishnan R, Anjana RM, Mohan V (2016) Diabetes mellitus and its complications in India. Nat Rev Endocrinol 12(6):357–370CrossRefPubMed
4.
5.
Chappelow AV, Tan K, Waheed NK, Kaiser PK (2012) Panretinal photocoagulation for proliferative diabetic retinopathy: pattern scan laser versus argon laser. Am J Ophthalmol 153(1):137–142CrossRefPubMed
6.
Cheung N, Wong IY, Wong TY (2014) Ocular anti-VEGF therapy for diabetic retinopathy: overview of clinical efficacy and evolving applications. Diabetes Care 37(4):900–905CrossRefPubMed
7.
Forster AS, Forbes A, Dodhia H et al (2013) Changes in detection of retinopathy in type 2 diabetes in the first 4 years of a population-based diabetic eye screening program: retrospective cohort study. Diabetes Care 36(9):2663–2669CrossRefPubMedPubMedCentral
8.
Early Treatment Diabetic Retinopathy Study Research Group (1991) Grading diabetic retinopathy from stereoscopic color fundus photographs—an extension of the modified Airlie House classification. ETDRS report number 10. Ophthalmology 98(5 Suppl):786–806
9.
Early Treatment Diabetic Retinopathy Study Research Group (1991) Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Ophthalmology 98(5 Suppl):766–785
10.
Wilkinson CP, Ferris FL 3rd, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110(9):1677–1682CrossRefPubMed
11.
American Academy of Ophthalmology Retina/Vitreous Panel (2016) Preferred practice pattern guidelines. Diabetic retinopathy, San Francisco, CA(American Academy of Ophthalmology):Available at: http://​www.​aao.​org/​ppp. Accessed 20 Sep 2014
12.
Stolk RP, van Schooneveld MJ, Cruickshank JK et al (2008) Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study. Diabetes Care 31(4):708–713CrossRefPubMed
13.
Early Treatment Diabetic Retinopathy Study Research Group (1991) Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Ophthalmology 98(5 Suppl):807–822
14.
Cole ED, Novais EA, Louzada RN, Waheed NK (2016) Contemporary retinal imaging techniques in diabetic retinopathy: a review. Clin Exp Ophthalmol 44(4):289–299CrossRefPubMed
15.
Lee VS, Kingsley RM, Lee ET et al (1993) The diagnosis of diabetic retinopathy. Ophthalmoscopy versus fundus photography. Ophthalmology 100(10):1504–1512CrossRefPubMed
16.
Patel SN, Klufas MA, Ryan MC et al (2015) Color fundus photography versus fluorescein angiography in identification of the macular center and zone in retinopathy of prematurity. Am J Ophthalmol 159(5):950–7e2CrossRefPubMedPubMedCentral
17.
Sato Y, Kamata A, Matsui M (1993) Clinical study of venous abnormalities in diabetic retinopathy. Jpn J Ophthalmol 37(2):136–142PubMed
18.
Imesch PD, Bindley CD, Wallow IH (1997) Clinicopathologic correlation of intraretinal microvascular abnormalities. Retina 17(4):321–329CrossRefPubMed
19.
Lee CS, Lee AY, Baughman D et al (2017) The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group: Report 3: Baseline Retinopathy and Clinical Features Predict Progression of Diabetic Retinopathy. Am J Ophthalmol 180:64–71CrossRefPubMedPubMedCentral
20.
Fonseca RA, Dantas MA (2002) Retinal venous beading associated with recurrent branch vein occlusion. Can J Ophthalmol 37(3):182–183CrossRefPubMed
21.
Keyser BJ, Ferguson JB 3rd (1997) Retinal venous beading with recurrent preretinal hemorrhage. Am J Ophthalmol 123(5):696–698CrossRefPubMed
22.
Beltramo E, Porta M (2013) Pericyte loss in diabetic retinopathy: mechanisms and consequences. Curr Med Chem 20(26):3218–3225CrossRefPubMed
23.
Wat N, Wong RLM, Wong IYH (2016) Associations between diabetic retinopathy and systemic risk factors. Hong Kong Med J 22(6):589–599PubMed
24.
Penman A, Hancock H, Papavasileiou E et al (2016) Risk factors for proliferative diabetic retinopathy in African Americans with type 2 diabetes. Ophthalmic Epidemiol 23(2):88–93CrossRefPubMedPubMedCentral
25.
Zou W, Ni L, Lu Q et al (2016) Diabetes onset at 31–45 years of age is associated with an increased risk of diabetic retinopathy in type 2 diabetes. Sci Rep 6:38113CrossRefPubMedPubMedCentral
26.
Lin S, Ramulu P, Lamoureux EL, Sabanayagam C (2016) Addressing risk factors, screening, and preventative treatment for diabetic retinopathy in developing countries: a review. Clin Exp Ophthalmol 44(4):300–320CrossRefPubMed
27.
Olafsdottir E, Andersson DK, Dedorsson I, Svardsudd K, Jansson SP, Stefansson E (2016) Early detection of type 2 diabetes mellitus and screening for retinopathy are associated with reduced prevalence and severity of retinopathy. Acta Ophthalmol 94(3):232–239CrossRefPubMed
28.
Leese GP, Stratton IM, Land M et al (2015) Progression of diabetes retinal status within community screening programs and potential implications for screening intervals. Diabetes Care 38:488–494 Diabetes Care, 38(12):E209-E210CrossRefPubMed
29.
Wang F, Liang Y, Zhang F et al (2009) Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology 116(3):461–467CrossRefPubMed
Metadata
Title
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy
Authors
Ling Chen
Xiongze Zhang
Feng Wen
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-018-3971-3

Other articles of this Issue 6/2018

Graefe's Archive for Clinical and Experimental Ophthalmology 6/2018 Go to the issue

Glaucoma

The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma

Basic Science

Cryopreservation of amniotic membrane with and without glycerol additive

Letter to the Editor

Polymegathism as a biomarker of mitochondrial disorders

Editorial

The legacy of Jules Gonin: one hundred years of identifying and treating retinal breaks

Retinal Disorders

23G pars plana vitrectomy for vitreal floaters: prospective assessment of subjective self-reported visual impairment and surgery-related risks during the course of treatment

Oculoplastics and Orbit

Concerns of anophthalmic patients—a comparison between cryolite glass and polymethyl methacrylate prosthetic eye wearers