Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-04-2018 | Retinal Disorders

Comparison of anterior segment optical coherence tomography angiography and fluorescein angiography for iris vasculature analysis

Authors: Claudio Zett, Deborah M. Rosa Stina, Renata Tiemi Kato, Eduardo Amorim Novais, Norma Allemann

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2018

Abstract

Purpose

The aim of this study is to perform imaging of irises of different colors using spectral domain anterior segment optical coherence tomography angiography (AS-OCTA) and iris fluorescein angiography (IFA) and compare their effectiveness in examining iris vasculature.

Methods

This is a cross-sectional observational clinical study. Patients with no vascular iris alterations and different pigmentation levels were recruited. Participants were imaged using OCTA adapted with an anterior segment lens and IFA with a confocal scanning laser ophthalmoscope (cSLO) adapted with an anterior segment lens. AS-OCTA and IFA images were then compared. Two blinded readers classified iris pigmentation and compared the percentage of visible vessels between OCTA and IFA images.

Results

Twenty eyes of 10 patients with different degrees of iris pigmentation were imaged using AS-OCTA and IFA. Significantly more visible iris vessels were observed using OCTA than using FA (W = 5.22; p < 0.001). Iris pigmentation was negatively correlated to the percentage of visible vessels in both imaging methods (OCTA, rho = − 0.73, p < 0.001; IFA, rho = − 0.77, p < 0.001). Unlike FA, AS-OCTA could not detect leakage of dye, delay, or impregnation. Nystagmus and inadequate fixation along with motion artifacts resulted in lower quality images in AS-OCTA than in IFA.

Conclusions

AS-OCTA is a new imaging modality which allows analysis of iris vasculature. In both AS-OCTA and IFA, iris pigmentation caused vasculature imaging blockage, but AS-OCTA provided more detailed iris vasculature images than IFA. Additional studies including different iris pathologies are needed to determine the most optimal scanning parameters in OCTA of the anterior segment.

Han SB, Mehta JS, Liu YC, Mohamed-Noriega K (2016) Advances and clinical applications of anterior segment imaging techniques. J Ophthalmol 2016:8529406. https://doi.org/10.1155/2016/8529406 PubMedPubMedCentral

Parodi MB, Bondel E, Saviano S, Ravalico G (1999) Iris fluorescein angiography and iris indocyanine green videoangiography in pseudoexfoliation syndrome. Eur J Ophthalmol 9:284–290CrossRefPubMed

Brancato R, Bandello F, Lattanzio R (1997) Iris fluorescein angiography in clinical practice. Surv Ophthalmol 42:41–70CrossRefPubMed

Maruyama Y, Kishi S, Kamei Y, Shimizu R, Kimura Y (1995) Infrared angiography of the anterior ocular segment. Surv Ophthalmol 39(Suppl 1):S40–S48CrossRefPubMed

Fariza E, Ormerod LD, O'Day T, Celorio JM (1991) Practical anterior segment fluorescein angiography. Graefes Arch Clin Exp Ophthalmol 229:105–110CrossRefPubMed

Gillies WE, Tangas C (1986) Fluorescein angiography of the iris in anterior segment pigment dispersal syndrome. Br J Ophthalmol 70:284–289CrossRefPubMedPubMedCentral

Lewis ML (1981) Iris fluorescein angiography. Dev Ophthalmol 2:282–285CrossRefPubMed

Lopez-Saez MP, Ordoqui E, Tornero P, Baeza A, Sainza T, Zubeldia JM, Baeza ML (1998) Fluorescein-induced allergic reaction. Ann Allergy Asthma Immunol 81:428–430. https://doi.org/10.1016/S1081-1206(10)63140-7 CrossRefPubMed

Obana A, Miki T, Hayashi K, Takeda M, Kawamura A, Mutoh T, Harino S, Fukushima I, Komatsu H, Takaku Y et al (1994) Survey of complications of indocyanine green angiography in Japan. Am J Ophthalmol 118:749–753CrossRefPubMed

10.

Kwiterovich KA, Maguire MG, Murphy RP, Schachat AP, Bressler NM, Bressler SB, Fine SL (1991) Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study. Ophthalmology 98:1139–1142CrossRefPubMed

11.

Yannuzzi LA, Rohrer KT, Tindel LJ, Sobel RS, Costanza MA, Shields W, Zang E (1986) Fluorescein angiography complication survey. Ophthalmology 93:611–617CrossRefPubMed

12.

Kaeser PF, Klainguti G (2012) Anterior segment angiography in strabismus surgery. Klin Monatsbl Augenheilkd 229:362–364. https://doi.org/10.1055/s-0031-1299283 CrossRefPubMed

13.

Bron AJ, Tripathi RC, Tripathi BJ (1997) Wolff's anatomy of the eye and orbit. Chapman & Hall Medical, London

14.

Hayreh SS, Scott WE (1978) Fluorescein iris angiography. I. Normal pattern. Arch Ophthalmol 96:1383–1389CrossRefPubMed

15.

de Carlo TE, Romano A, Waheed NK, Duker JS (2015) A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous 1:5. https://doi.org/10.1186/s40942-015-0005-8 CrossRefPubMedPubMedCentral

16.

Cai Y, Alio Del Barrio JL, Wilkins MR, Ang M (2016) Serial optical coherence tomography angiography for corneal vascularization. Graefes Arch Clin Exp Ophthalmol. https://doi.org/10.1007/s00417-016-3505-9

17.

Ang M, Cai Y, Tan AC (2016) Swept source optical coherence tomography angiography for contact lens-related corneal vascularization. J Ophthalmol 2016:9685297. https://doi.org/10.1155/2016/9685297 CrossRefPubMedPubMedCentral

18.

Ang M, Cai Y, Shahipasand S, Sim DA, Keane PA, Sng CC, Egan CA, Tufail A, Wilkins MR (2016) En face optical coherence tomography angiography for corneal neovascularisation. Br J Ophthalmol 100:616–621. https://doi.org/10.1136/bjophthalmol-2015-307338 CrossRefPubMed

19.

Ang M, Cai Y, Mac Phee B, Sim DA, Keane PA, Sng CC, Egan CA, Tufail A, Larkin DF, Wilkins MR (2016) Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation. Br J Ophthalmol. https://doi.org/10.1136/bjophthalmol-2015-307706

20.

Ang M, Sim DA, Keane PA, Sng CC, Egan CA, Tufail A, Wilkins MR (2015) Optical coherence tomography angiography for anterior segment vasculature imaging. Ophthalmology 122:1740–1747. https://doi.org/10.1016/j.ophtha.2015.05.017 CrossRefPubMed

21.

Skalet AH, Li Y, Lu CD, Jia Y, Lee B, Husvogt L, Maier A, Fujimoto JG, Thomas CR, Jr., Huang D (2017) Optical coherence tomography angiography characteristics of iris melanocytic tumors. Ophthalmology 124: 197–204 DOI https://doi.org/10.1016/j.ophtha.2016.10.003

22.

Chien JL, Sioufi K, Ferenczy S, Say EAT, Shields CL (2017) Optical coherence tomography angiography features of iris racemose hemangioma in 4 cases. JAMA Ophthalmol. https://doi.org/10.1001/jamaophthalmol.2017.3390

23.

Allegrini D, Montesano G, Pece A (2016) Optical coherence tomography angiography in a normal iris. Ophthalmic Surg Lasers Imaging Retina 47:1138–1139. https://doi.org/10.3928/23258160-20161130-08 CrossRefPubMed

24.

Roberts PK, Goldstein DA, Fawzi AA (2017) Anterior segment optical coherence tomography angiography for identification of iris vasculature and staging of iris neovascularization: a pilot study. Curr Eye Res:1–7. https://doi.org/10.1080/02713683.2017.1293113

25.

Mackey DA, Wilkinson CH, Kearns LS, Hewitt AW (2011) Classification of iris colour: review and refinement of a classification schema. Clin Exp Ophthalmol 39:462–471. https://doi.org/10.1111/j.1442-9071.2010.02487.x CrossRefPubMed

26.

Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710–4725. https://doi.org/10.1364/OE.20.004710 CrossRefPubMedPubMedCentral

27.

Allegrini D, Montesano G, Pece A (2016) Optical coherence tomography angiography of iris nevus: a case report. Case Rep Ophthalmol 7:172–178. https://doi.org/10.1159/000450572 CrossRefPubMedPubMedCentral

28.

Carrasco-Zevallos OM, Nankivil D, Viehland C, Keller B, Izatt JA (2016) Pupil tracking for real-time motion corrected anterior segment optical coherence tomography. PLoS One 11:e0162015. https://doi.org/10.1371/journal.pone.0162015 CrossRefPubMedPubMedCentral

29.

Spaide RF, Fujimoto JG, Waheed NK (2015) Image artifacts in optical coherence tomography angiography. Retina 35:2163–2180. https://doi.org/10.1097/IAE.0000000000000765 CrossRefPubMedPubMedCentral

Title: Comparison of anterior segment optical coherence tomography angiography and fluorescein angiography for iris vasculature analysis
Authors: Claudio Zett
Deborah M. Rosa Stina
Renata Tiemi Kato
Eduardo Amorim Novais
Norma Allemann
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-3935-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparison of anterior segment optical coherence tomography angiography and fluorescein angiography for iris vasculature analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2018

Correlation between central stromal demarcation line depth and changes in K values after corneal cross-linking (CXL)

The effect of non-neovascular age-related macular degeneration on face recognition performance

Mortality associated with bevacizumab intravitreal injections in age-related macular degeneration patients after acute myocardial infarct: a retrospective population-based survival analysis

Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy

The fate of eyes with wet AMD beyond four years of anti-VEGF therapy

Normative measurements of inferior oblique muscle thickness in Japanese by magnetic resonance imaging using a new technique