Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 8/2016

01-08-2016 | Glaucoma

Retinal vessel diameter in bilateral glaucoma suspects: comparison between the eye converted to glaucoma and the contralateral non-converted eye

Authors: Eunjoo Yoo, Chungkwon Yoo, Tae-Eun Lee, Yong Yeon Kim

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 8/2016

Login to get access

Abstract

Purpose

To investigate retinal vessel diameter in patients classified as bilateral glaucoma suspects who showed unilateral glaucomatous conversion.

Methods

This retrospective study included 21 patients who had initially been diagnosed as bilateral glaucoma suspects but showed unilateral glaucomatous conversion during a follow-up period of more than 2 years. Conversion to glaucoma was determined either by documentation of a new retinal nerve fiber layer defect on red-free photography or a reproducible glaucomatous visual field defect. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured from fundus photographs taken at baseline and at the point of glaucoma conversion.

Results

The mean CRAE of the converted eyes was significantly lower than that of the non-converted eyes at baseline (164.9 ± 13.2 μm vs 175.2 ± 15.6 μm; p = 0.001), but no significant difference was observed in the mean CRVE (p = 0.108). The mean CRAE of the converted eyes was also lower than in the non-converted eyes at the point of glaucoma conversion (158.6 ± 13.5 μm vs 168.0 ± 17.2 μm; p = 0.011).

Conclusion

In bilateral glaucoma suspects, there was a significant inter-eye difference in CRAE at baseline between eyes that converted to glaucoma and those that did not. These findings suggest that measurement of retinal arteriolar diameter may help clinicians when evaluating the risk of conversion in glaucoma suspects.
Literature
3.
go back to reference Tielsch JM, Katz J, Quigley HA et al (1988) Intraobserver and interobserver agreement in measurement of optic disc characteristics. Ophthalmology 95:350–356CrossRefPubMed Tielsch JM, Katz J, Quigley HA et al (1988) Intraobserver and interobserver agreement in measurement of optic disc characteristics. Ophthalmology 95:350–356CrossRefPubMed
5.
go back to reference Iverson SM, Feuer WJ, Shi W, Greenfield DS (2014) Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study. Br J Ophthalmol 98:920–925. doi:10.1136/bjophthalmol-2013-303877 CrossRefPubMed Iverson SM, Feuer WJ, Shi W, Greenfield DS (2014) Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study. Br J Ophthalmol 98:920–925. doi:10.​1136/​bjophthalmol-2013-303877 CrossRefPubMed
6.
7.
go back to reference Da Pozzo S, Fuser M, Vattovani O, Di Stefano G, Ravalico G (2006) GDx-VCC performance in discriminating normal from glaucomatous eyes with early visual field loss. Graefes Arch Clin Exp Ophthalmol 244:689–695. doi:10.1007/s00417-005-0144-y CrossRefPubMed Da Pozzo S, Fuser M, Vattovani O, Di Stefano G, Ravalico G (2006) GDx-VCC performance in discriminating normal from glaucomatous eyes with early visual field loss. Graefes Arch Clin Exp Ophthalmol 244:689–695. doi:10.​1007/​s00417-005-0144-y CrossRefPubMed
8.
go back to reference Leung CK, Cheung CY, Weinreb RN, Qiu K, Liu S, Li H, Xu G, Fan N, Pang CP, Tse KK, Lam DS (2010) Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis. Invest Ophthalmol Vis Sci 51:217–222. doi:10.1167/iovs.09-3468 CrossRefPubMed Leung CK, Cheung CY, Weinreb RN, Qiu K, Liu S, Li H, Xu G, Fan N, Pang CP, Tse KK, Lam DS (2010) Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis. Invest Ophthalmol Vis Sci 51:217–222. doi:10.​1167/​iovs.​09-3468 CrossRefPubMed
9.
go back to reference Bowd C, Balasubramanian M, Weinreb RN, Vizzeri G, Alencar LM, O’Leary N, Sample PA, Zangwill LM (2009) Performance of confocal scanning laser tomograph topographic change analysis (TCA) for assessing glaucomatous progression. Invest Ophthalmol Vis Sci 50:691–701. doi:10.1167/iovs.08-2136 CrossRefPubMed Bowd C, Balasubramanian M, Weinreb RN, Vizzeri G, Alencar LM, O’Leary N, Sample PA, Zangwill LM (2009) Performance of confocal scanning laser tomograph topographic change analysis (TCA) for assessing glaucomatous progression. Invest Ophthalmol Vis Sci 50:691–701. doi:10.​1167/​iovs.​08-2136 CrossRefPubMed
10.
11.
go back to reference Burr JM, Mowatt G, Hernandez R, Siddiqui MA, Cook J, Lourenco T, Ramsay C, Vale L, Fraser C, Azuara-Blanco A, Deeks J, Cairns J, Wormald R, McPherson S, Rabindranath K, Grant A (2007) The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation. Health Technol Assess 11(41): iii–iv, ix–x, 1–190 Burr JM, Mowatt G, Hernandez R, Siddiqui MA, Cook J, Lourenco T, Ramsay C, Vale L, Fraser C, Azuara-Blanco A, Deeks J, Cairns J, Wormald R, McPherson S, Rabindranath K, Grant A (2007) The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation. Health Technol Assess 11(41): iii–iv, ix–x, 1–190
12.
go back to reference Amerasinghe N, Aung T, Cheung N, Fong CW, Wang JJ, Mitchell P, Saw SM, Wong TY (2008) Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population. Invest Ophthalmol Vis Sci 49:5397–5402. doi:10.1167/iovs.08-2142 CrossRefPubMed Amerasinghe N, Aung T, Cheung N, Fong CW, Wang JJ, Mitchell P, Saw SM, Wong TY (2008) Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population. Invest Ophthalmol Vis Sci 49:5397–5402. doi:10.​1167/​iovs.​08-2142 CrossRefPubMed
16.
go back to reference Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, 2nd, Wilson MR, Gordon MO (2002) The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 120(6):701–713, discussion 829–730 Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, 2nd, Wilson MR, Gordon MO (2002) The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 120(6):701–713, discussion 829–730
17.
go back to reference Anderson DR, Patella VM (1999) Automated static perimetry, 2nd edn. Mosby, St. Louis, pp 121–190 Anderson DR, Patella VM (1999) Automated static perimetry, 2nd edn. Mosby, St. Louis, pp 121–190
18.
go back to reference Berger JW, Patel TR, Shin DS, Piltz JR, Stone RA (2000) Computerized stereochronoscopy and alternation flicker to detect optic nerve head contour change. Ophthalmology 107:1316–1320CrossRefPubMed Berger JW, Patel TR, Shin DS, Piltz JR, Stone RA (2000) Computerized stereochronoscopy and alternation flicker to detect optic nerve head contour change. Ophthalmology 107:1316–1320CrossRefPubMed
20.
go back to reference Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE (2003) Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 27:143–149CrossRefPubMed Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE (2003) Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 27:143–149CrossRefPubMed
22.
go back to reference Yamada H, Hangai M, Nakano N, Takayama K, Kimura Y, Miyake M, Akagi T, Ikeda HO, Noma H, Yoshimura N (2014) Asymmetry analysis of macular inner retinal layers for glaucoma diagnosis. Am J Ophthalmol 158:1318.e3–1329.e3. doi:10.1016/j.ajo.2014.08.040 CrossRef Yamada H, Hangai M, Nakano N, Takayama K, Kimura Y, Miyake M, Akagi T, Ikeda HO, Noma H, Yoshimura N (2014) Asymmetry analysis of macular inner retinal layers for glaucoma diagnosis. Am J Ophthalmol 158:1318.e3–1329.e3. doi:10.​1016/​j.​ajo.​2014.​08.​040 CrossRef
24.
go back to reference Riva CE, Grunwald JE, Sinclair SH, Petrig BL (1985) Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci 26:1124–1132PubMed Riva CE, Grunwald JE, Sinclair SH, Petrig BL (1985) Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci 26:1124–1132PubMed
25.
go back to reference Kim JM, Sae Kim M, Ju Jang H, Ho Park K, Caprioli J (2012) The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients. Invest Ophthalmol Vis Sci 53:5609–5614. doi:10.1167/iovs.12-9783 CrossRefPubMed Kim JM, Sae Kim M, Ju Jang H, Ho Park K, Caprioli J (2012) The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients. Invest Ophthalmol Vis Sci 53:5609–5614. doi:10.​1167/​iovs.​12-9783 CrossRefPubMed
27.
go back to reference Piltz-seymour JR, Grunwald JE, Hariprasad SM, Dupont J (2001) Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects. Am J Ophthalmol 132:63–69CrossRefPubMed Piltz-seymour JR, Grunwald JE, Hariprasad SM, Dupont J (2001) Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects. Am J Ophthalmol 132:63–69CrossRefPubMed
30.
go back to reference Wong TY, Knudtson MD, Klein R, Klein BE, Meuer SM, Hubbard LD (2004) Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 111:1183–1190. doi:10.1016/j.ophtha.2003.09.039 CrossRefPubMed Wong TY, Knudtson MD, Klein R, Klein BE, Meuer SM, Hubbard LD (2004) Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 111:1183–1190. doi:10.​1016/​j.​ophtha.​2003.​09.​039 CrossRefPubMed
31.
go back to reference Polo V, Larrosa JM, Pinilla I, Perez S, Gonzalvo F, Honrubia FM (2002) Predictive value of short-wavelength automated perimetry: a 3-year follow-up study. Ophthalmology 109:761–765CrossRefPubMed Polo V, Larrosa JM, Pinilla I, Perez S, Gonzalvo F, Honrubia FM (2002) Predictive value of short-wavelength automated perimetry: a 3-year follow-up study. Ophthalmology 109:761–765CrossRefPubMed
33.
go back to reference Mwanza JC, Durbin MK, Budenz DL, Sayyad FE, Chang RT, Neelakantan A, Godfrey DG, Carter R, Crandall AS (2012) Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head. Ophthalmology 119:1151–1158. doi:10.1016/j.ophtha.2011.12.014 CrossRefPubMed Mwanza JC, Durbin MK, Budenz DL, Sayyad FE, Chang RT, Neelakantan A, Godfrey DG, Carter R, Crandall AS (2012) Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head. Ophthalmology 119:1151–1158. doi:10.​1016/​j.​ophtha.​2011.​12.​014 CrossRefPubMed
34.
go back to reference Sherry LM, Wang JJ, Rochtchina E, Wong T, Klein R, Hubbard L, Mitchell P (2002) Reliability of computer-assisted retinal vessel measurement in a population. Clin Experiment Ophthalmol 30:179–182CrossRefPubMed Sherry LM, Wang JJ, Rochtchina E, Wong T, Klein R, Hubbard L, Mitchell P (2002) Reliability of computer-assisted retinal vessel measurement in a population. Clin Experiment Ophthalmol 30:179–182CrossRefPubMed
35.
go back to reference Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, Pinsky JL, Klein R (1999) Retinal arteriolar diameters and elevated blood pressure: the atherosclerosis risk in communities study. Am J Epidemiol 150:263–270CrossRefPubMed Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, Pinsky JL, Klein R (1999) Retinal arteriolar diameters and elevated blood pressure: the atherosclerosis risk in communities study. Am J Epidemiol 150:263–270CrossRefPubMed
41.
42.
go back to reference Hao H, Sasongko MB, Wong TY, Che Azemin MZ, Aliahmad B, Hodgson L, Kawasaki R, Cheung CY, Wang JJ, Kumar DK (2012) Does retinal vascular geometry vary with cardiac cycle? Invest Ophthalmol Vis Sci 53:5799–5805. doi:10.1167/iovs.11-9326 CrossRefPubMed Hao H, Sasongko MB, Wong TY, Che Azemin MZ, Aliahmad B, Hodgson L, Kawasaki R, Cheung CY, Wang JJ, Kumar DK (2012) Does retinal vascular geometry vary with cardiac cycle? Invest Ophthalmol Vis Sci 53:5799–5805. doi:10.​1167/​iovs.​11-9326 CrossRefPubMed
44.
go back to reference Lalezary M, Medeiros FA, Weinreb RN, Bowd C, Sample PA, Tavares IM, Tafreshi A, Zangwill LM (2006) Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects. Am J Ophthalmol 142:576–582. doi:10.1016/j.ajo.2006.05.004 CrossRefPubMed Lalezary M, Medeiros FA, Weinreb RN, Bowd C, Sample PA, Tavares IM, Tafreshi A, Zangwill LM (2006) Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects. Am J Ophthalmol 142:576–582. doi:10.​1016/​j.​ajo.​2006.​05.​004 CrossRefPubMed
Metadata
Title
Retinal vessel diameter in bilateral glaucoma suspects: comparison between the eye converted to glaucoma and the contralateral non-converted eye
Authors
Eunjoo Yoo
Chungkwon Yoo
Tae-Eun Lee
Yong Yeon Kim
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 8/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-016-3392-0

Other articles of this Issue 8/2016

Graefe's Archive for Clinical and Experimental Ophthalmology 8/2016 Go to the issue