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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2015

01-04-2015 | Glaucoma

Retinal vascular caliber between eyes with asymmetric glaucoma

Authors: John Mark S. De Leon, Carol Y. Cheung, Tien-Yin Wong, Xiang Li, Haslina Hamzah, Tin Aung, Daniel Hsien-Wen SU

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2015

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Abstract

Purpose

To compare differences in retinal arterial and venular caliber (RAC and RVC respectively) between fellow eyes with glaucoma of asymmetric severity.

Methods

We included subjects with bilateral primary glaucoma that had vertical cup–disc ratios (VCDR) >0.2 between both eyes, or visual field (VF) mean deviation (MD) >6.0 decibels (dB) between both eyes.

Results

Among 158 subjects, the average RAC in glaucoma eyes was 131.5 ± 17.8 μm vs 141.6 ± 18.8 μm in fellow eyes with mild disease (p < 0.001). RVCs in glaucoma eyes were 201.0 ± 21.4 μm vs 211.7 ± 25.3 μm in fellow eyes with mild disease (p < 0.001). This relationship held in clustered linear regression models adjusted for age, gender, vascular risk factors, visual acuity, axial length, and intraocular pressure, with RVCs narrower in eyes with worse disease vs mild disease. Eyes with worse disease had greater VCDR (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.001), and worse VF MD (−18.5 ± 8.6 vs −6.6 ± 5.6, p < 0.001).

Conclusion

In glaucoma with asymmetric severity between fellow eyes, retinal vascular caliber is less in the eye with more severe disease.
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Metadata
Title
Retinal vascular caliber between eyes with asymmetric glaucoma
Authors
John Mark S. De Leon
Carol Y. Cheung
Tien-Yin Wong
Xiang Li
Haslina Hamzah
Tin Aung
Daniel Hsien-Wen SU
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2895-9

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