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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-04-2015 | Glaucoma

Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects

Authors: Henrietta Ho, Mineo Ozaki, Takanori Mizoguchi, Shamira A. Perera, Daniel H. Su, Mingguang He, Tien Y. Wong, Monisha E. Nongpiur, Tin Aung

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2015

Abstract

Purpose

To compare anterior segment parameters in Chinese and Japanese subjects with angle closure using anterior segment optical coherence tomography (ASOCT).

Methods

One hundred and forty-two Japanese and one hundred and ninety-two Chinese subjects with primary angle closure (PAC) or primary angle-closure glaucoma (PACG) were recruited. All participants underwent A-scan biometry and ASOCT imaging (Visante, Carl Zeiss Meditec, Dublin, CA, USA). Customized software was used to measure ASOCT parameters in horizontal ASOCT scans. The parameters were compared, and multivariate analysis was performed to determine predictors of angle opening distance at 750 μm from the scleral spur (AOD750).

Results

Ethnic difference evaluated by multiple linear regression adjusted for age, gender, spherical equivalent, pupil diameter, and axial length showed that Japanese angle-closure subjects had significantly shallower anterior chamber depth (ACD;β = −0.3, p < 0.001), smaller anterior chamber area (ACA; β = −0.21, p = 0.02) and volume (ACV; β = −0.19, p = 0.01), greater lens vault (LV, β = 0.3, p < 0.001), lens thickness (LT; β = 0.48, p < 0.001), greater iris area (IArea; β = 0.19, p = 0.01), and more curved iris (ICurv; β = 0.16, p = 0.04). The significant determinants of AOD750 were iris thickness (IT; β = −0.21, p = 0.04), ICurv (β = −0.17, p = 0.04), pupil diameter (PD; β = −0.34, p = 0.001) and ACV (β = 0.32, p < 0.001) in Japanese; and IT (β = −0.25, p = 0.001), ACV (β = 0.37, p < 0.001), PD (β = −0.26, p = 0.001), and LV (β = −0.18, p = 0.03) in Chinese.

Conclusions

Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses. ACV, IT, and PD are important factors for angle width in both races. These results suggest possible ethnic differences in angle-closure mechanism(s).

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Title: Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects
Authors: Henrietta Ho
Mineo Ozaki
Takanori Mizoguchi
Shamira A. Perera
Daniel H. Su
Mingguang He
Tien Y. Wong
Monisha E. Nongpiur
Tin Aung
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-2935-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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