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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2015

01-04-2015 | Pathology

A pilot study on total, corneal, and internal aberrations in insulin-dependent and non-insulin-dependent diabetes mellitus patients

Authors: Ana M. Calvo-Maroto, Rafael J. Pérez-Cambrodí, Santiago García-Lázaro, César Albarrán-Diego, Alejandro Cerviño

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2015

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Abstract

Purpose

To explore the distribution of total, corneal, and internal higher-order aberrations (HOAs) in both insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetic patients.

Methods

Pilot study including seven patients with IDDM (14 eyes) and 11 patients with NIDDM (22 eyes). Ocular HOAs were examined using ray tracing aberrometry (i-Trace, Tracey Technologies Corp., Houston, TX) and the measurements of anterior segment using Scheimpflug imaging (Pentacam, Oculus Inc. Germany).

Results

Total HOAs was slightly higher in IDDM (0.634 ± 0.228 μm, 95% IC ± 0.131) than in NIDDM patients (0.527 ± 0.245 μm, 95% IC ± 0.108) (p = 0.267). The greatest contributor for total ocular HOAs was internal vertical coma (Z3 − 1) for both diabetic groups. In NIDDM, age and central corneal thickness (CCT) were correlated with total HOAs (p < 0.001, p = 0.0180 respectively); however, anterior chamber volume (ACV) was inversely correlated with total HOAs (p = 0.019). In IDDM, total HOAs were correlated with posterior asphericity (Q) (p = 0.002) and inversely correlated with ageing (p = 0.013).

Conclusions

Diabetic patients showed high values of total and internal vertical coma (Z3 − 1). There might be a role for optical quality measurements in monitoring changes due to DM.
Literature
1.
Williams R, Airey M, Baxter H, Forrester J, Kennedy-Martin T, Girach A (2004) Epidemiology of diabetic retinopathy and macular oedema: a systematic review. Eye (Lond) 18:963–983CrossRef
2.
Ederer F, Hiller R, Taylor HR (1981) Senile lens changes and diabetes in two population studies. Am J Ophthalmol 91:381–395CrossRefPubMed
3.
Nielsen NV, Vinding T (1984) The prevalence of cataract in insulin-dependent and non-insulin dependent diabetes mellitus. Acta Ophthalmol (Copenh) 62:595–602CrossRef
4.
Klein BE, Klein R, Moss RE (1985) Prevalence of cataracts in a population-based study of person with diabetes mellitus. Ophthalmology 92:1191–1196CrossRefPubMed
5.
Sahin A, Bayer A, Ozge G, Mumcuoglu T (2009) Corneal biomechanical changes in diabetes mellitus and their influence on intraocular pressure measurements. Invest Ophthalmol Vis Sci 50:4597–4604CrossRefPubMed
6.
7.
Qwinp G, Villareal A (1976) Relationship of serum glucose concentration to changes in refraction. Diabetes 25:29–31CrossRef
8.
Dogru M, Katakami C, Inoue M (2001) Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology 108:586–592CrossRefPubMed
9.
Ozdemir M, Buyukbese MA, Cetinkaya A, Ozdemir G (2003) Risk factors for ocular surface disorders in patients with diabetes mellitus. Diabetes Res Clin Pract 59:195–199CrossRefPubMed
10.
Yoon KC, Im SK, Seo MS (2004) Changes of tear film and ocular surface in diabetes mellitus. Korean J Ophthalmol 18:168–174CrossRefPubMed
11.
12.
13.
Rehany U, Ishii Y, Lahav M, Rumelt S (2000) Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study. Cornea 19:534–538CrossRefPubMed
14.
Brown N, Hungerford J (1982) The influence of the size of the lens in ocular disease. Trans Ophthalmol Soc U K 102:359–363PubMed
15.
Bron AJ, Sparrow J, Brown NA, Harding JJ, Blakytny R (1993) The lens in diabetes. Eye (Lond) 7:260–275CrossRef
16.
Liang J, Williams DR (1997) Aberrations and retinal image quality of the normal human eye. J Opt Soc Am A Opt Image Sci Vis 14:2873–2883CrossRefPubMed
17.
Schlegel Z, Lteif Y, Bains HS, Gatinel D (2009) Total, corneal, and internal ocular optical aberrations in patients with keratoconus. J Refract Surg 25:S951–S957CrossRefPubMed
18.
Gobbe M, Guillon M (2005) Corneal wavefront aberration measurements to detect keratoconus patients. Cont Lens Anterior Eye 28:57–66CrossRefPubMed
19.
Oliveira CM, Ferreira A, Franco S (2012) Wavefront analysis and Zernike polynomial decomposition for evaluation of corneal optical quality. J Cataract Refract Surg 38:343–356CrossRefPubMed
20.
Wiemer NG, Dubbelman M, Ringens PJ, Polak BC (2009) Measuring the refractive properties of the diabetic eye during blurred vision and hyperglycaemia using aberrometry and Scheimpflug imaging. Acta Ophthalmol 87:176–182CrossRefPubMed
21.
Shahidi M, Blair NP, Mori Z, Zelkha R (2004) Optical section retinal imaging and wavefront sensing in diabetes. Optom Vis Sci 81:778–784CrossRefPubMed
22.
Cerviño A, Hosking SL, Montes-Mico R, Bates K (2007) Clinical ocular wavefront analyzers. J Refract Surg 23:603–616PubMed
23.
Lombardo M, Lombardo G (2010) Wave aberration of human eyes and new descriptors of image optical quality and visual performance. J Cataract Refract Surg 36:313–331CrossRefPubMed
24.
Montés-Micó R, Alió JL, Muñoz G, Pérez-Santonja JJ, Charman WN (2004) Postblink changes in total and corneal ocular aberrations. Ophthalmology 111:758–767CrossRefPubMed
25.
Thibos L, Wheeler W, Horner D (1997) Power Vectors: an application of Fourier analysis to the description and statistical analysis of refractive error. Optom Vis Sci 74:367–375CrossRefPubMed
26.
Inoue K, Kato S, Inoue Y, Amano S, Oshika T (2002) The corneal endothelium and thickness in type II diabetes mellitus. Jpn J Ophthalmol 46:65–69CrossRefPubMed
27.
Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G (1999) Corneal endothelium evaluation in type I and type II diabetes mellitus [Abstract]. Ophthalmologica 213:258–261CrossRefPubMed
28.
Hager A, Wegscheider K, Wiegand W (2009) Changes of extracellular matrix of the cornea in diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 247:1369–1374CrossRefPubMed
29.
Stitt AW, Moore JE, Sharkey JA, Murphy G, Simpson DA, Bucala R, Vlassara H, Archer DB (1998) Advanced glycation end products in vitreous: structural and functional implications for diabetic vitreopathy. Invest Ophthalmol Vis Sci 39:2517–2523PubMed
30.
Porter J, Guirao A, Cox IG, Williams DR (2001) Monochromatic aberrations of the human eye in a large population. J Opt Soc Am A Opt Image Sci Vis 18:1793–1803CrossRefPubMed
31.
Castejón-Mochón JF, López-Gil N, Benito A, Artal P (2002) Ocular wave-front aberration statistics in a normal young population. Vision Res 42:1611–1617CrossRefPubMed
32.
Wang L, Koch DD (2003) Ocular higher-order aberrations in individuals screened for refractive surgery. J Cataract Refract Surg 29:1896–1903CrossRefPubMed
33.
Wang L, Santaella RM, Booth M, Koch DD (2005) Higher-order aberrations from the internal optics of the eye. J Cataract Refract Surg 31:1512–1519CrossRefPubMed
34.
Wang L, Dai E, Koch DD, Nathoo A (2003) Optical aberrations of the human anterior cornea. J Cataract Refract Surg 29:1514–1521CrossRefPubMed
35.
Artal P, Guirao A, Berrio E, Williams DR (2001) Compensation of corneal aberrations by the internal optics in the human eye. J Vis 1:1–8CrossRefPubMed
36.
He JC, Gwiazda J, Thorn F, Held R (2003) Wave-front aberrations in the anterior corneal surface and the whole eye. J Opt Soc Am A Opt Image Vis Sci 20:1155–1163CrossRef
37.
Kelly JE, Mihashi T, Howland HC (2004) Compensation of corneal horizontal/vertical astigmatism, lateral coma, and spherical aberration by internal optics of the eye. J Vis 4:262–271CrossRefPubMed
38.
Guirao A, Redondo M, Artal P (2000) Optical aberrations of the human cornea as a function of age. J Opt Soc Am A Opt Image Sci Vis 17:1697–1702CrossRefPubMed
39.
Dubbelman M, Sicam VA, van der Heijde RG (2007) The contribution of the posterior surface to the coma aberration of the human cornea. J Vis 7:1–8CrossRef
Metadata
Title
A pilot study on total, corneal, and internal aberrations in insulin-dependent and non-insulin-dependent diabetes mellitus patients
Authors
Ana M. Calvo-Maroto
Rafael J. Pérez-Cambrodí
Santiago García-Lázaro
César Albarrán-Diego
Alejandro Cerviño
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2864-3

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