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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 3/2013

01-03-2013 | Retinal Disorders

Serum cortisol and testosterone levels in chronic central serous chorioretinopathy

Authors: Hasan Ali Tufan, Baran Gencer, Arzu Taskiran Comez

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2013

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Abstract

Purpose

To investigate the potential role of serum cortisol and testosterone levels in chronic central serous chorioretinopathy (CSC).

Material and methods

Serum cortisol and testosterone levels of six male patients with chronic CSC were evaluated by chemiluminescent immunassay. Hormone levels were compared with the normal reference values of healthy people.

Results

All patients were male, and the median age was 48 years (range: 42–54). The median duration of visual disturbance at presentation was 23 months (range: 12–48). Median 8:00 a.m. serum cortisol level was 11.6 μg/dl (min. 4.74, max. 18.3) and the cortisol levels were within the normal range in five of the six patients. All patients had normal serum testosterone levels, with a median value of 549.5 ng/ml (min. 246, max. 794).

Conclusion

Serum cortisol and testosterone levels were within normal ranges and in patients with chronic CSC. The association between these hormones and chronic CSC might be weak.
Literature
1.
Yanuzzi LA (1986) Type: A behavior and central serous chorioretinopathy. Trans Am Ophthalmol Soc 84:799–845
2.
Hussain D, Gass JD (1998) Idiopathic central serous chorioretinopathy. Indian J Ophthalmol 46:131–137PubMed
3.
Gass JDM (1967) Pathogenesis of disciform detachment of the neuroepithelium II. Idiopathic central serous choroidopathy. Am J Ophthalmol 63:587–615
4.
Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR, Slakter JS, Sorenson JA, Orlock DA (1996) Central serous chorioretinopathy in younger and older adults. Ophthalmology 103:2070–2079PubMed
5.
Tittl MK, Spaide RF, Wong D, Pilotto E, Yannuzzi LA, Fisher YL, Freund B, Guyer DR, Slakter JS, Sorenson JA (1999) Systemic findings associated with central serous chorioretinopathy. Am J Ophthalmol 128:63–68PubMedCrossRef
6.
Jain IS, Singh K (1966) Maculopathy a corticosteroid side-effect. J All India Ophthalmol Soc 14:250–252PubMed
7.
Bouzas EA, Scott MH, Mastorakos G, Chrousos GP, Kaiser-Kupfer MI (1993) Central serous chorioretinopathy in endogenous hypercortisolism. Arch Ophthalmol 111:1229–1233PubMedCrossRef
8.
Thoelen AM, Bernasconi PP, Schmid C, Messmer EP (2000) Central serous chorioretinopathy associated with a carcinoma of the adrenal cortex. Retina 20:98–99PubMedCrossRef
9.
Zumoff B, Rosenfeld RS, Friedman M, Byers SO, Rosenman RH, Hellman L (1984) Elevated daytime urinary excretion of testesterone glucuronide in men with type A behavior pattern. Psychocom Med 46:223–225
10.
Rocha EM, Wickham LA, da Silveira LA, Krenzer KL, Yu FS, Toda I, Sullivan BD, Sullivan DA (2000) Identification of androgen receptor protein and 5 alpha-reductase mRNA in human ocular tissues. Br J Ophthalmol 84:76–84PubMedCrossRef
11.
Ahad MA, Chua CN, Evans NM (2006) Central serous chorioretinopathy associated with testosterone therapy. Eye 20:503–505PubMedCrossRef
12.
Grieshaber MC, Staub JJ, Flammer J (2007) The potential role of testosterone in central serous chorioretinopathy. Br J Ophthalmol 91:118–119PubMedCrossRef
13.
Jacobson L (2005) Hypothalamic–pituitary–adrenocortical axis regulation. Endocrinol Metab Clin North Am 34:271–292PubMedCrossRef
14.
Valero-Politi J, Fuentes-Arderiu X (1996) Daily rhythmic and non-rhythmic variations of follitropin, lutropin, testosterone, and sex-hormone-binding globulin in men. Eur J Clin Chem Clin Biochem 34:455–62PubMed
15.
Matsumoto AM, Bremner WJ (2011) Testosterone disorders. In : Melmed S, Polonsky KS, Larsen PR, Kronenberg HM (eds.) Williams textbook of endocrinology.Saunders Elsevier, Philadelphia, pp 724-732
16.
Kapetanios AD, Donati G, Bouzas E, Mastorakos G, Pournaras CJ (1998) Serous central chorioretinopathy and endogenous hypercortisolemia. Klin Monatsbl Augenheilkd 212:343–344PubMedCrossRef
17.
Garg SP, Dada T, Talwar D, Biswas NR (1997) Endogenous cortisol profile in patients with central serous chorioretinopathy. Br J Ophthalmol 81:962–964PubMedCrossRef
18.
Zakir SM, Shukla M, Simi ZU, Ahmad J, Sajid M (2009) Serum cortisol and testosterone levels in idiopathic central serous chorioretinopathy. Indian J Ophthalmol 57:419–422PubMedCrossRef
19.
Haimovici R, Rumelt S, Melby J (2003) Endocrine abnormalities in patients with central serous chorioretinopathy. Ophthalmology 110:698–703PubMedCrossRef
20.
Forooghian F, Meleth AD, Cukras C, Chew EY, Wong WT, Meyerle CB (2011) Finasteride for chronic central serous chorioretinopathy. Retina 31:766–771PubMed
21.
Meyerle CB, Freund KB, Bhatnagar P, Shah V, Yannuzzi LA (2007) Ketoconazole in the treatment of chronic idiopathic central serous chorioretinopathy. Retina 27:943–946PubMedCrossRef
22.
Carpenter MT, O'Boyle JE, Enzenauer RW, Enzenauer RJ, Waterhouse WJ (1994) Choroiditis in systemic lupus erythematosus. Am J Ophthalmol 117:535–536PubMed
Metadata
Title
Serum cortisol and testosterone levels in chronic central serous chorioretinopathy
Authors
Hasan Ali Tufan
Baran Gencer
Arzu Taskiran Comez
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-012-2075-8

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