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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-07-2008 | Retinal Disorders

One-year results of a multicenter controlled clinical trial of triamcinolone in pars plana vitrectomy

Authors: Keita Yamakiri, Taiji Sakamoto, Yoshihiro Noda, Masaaki Nakahara, Nobuchika Ogino, Toshiaki Kubota, Mitsunobu Yokoyama, Mariko Furukawa, Tatsuro Ishibashi

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2008

Abstract

Purpose

To evaluate the 1-year results of using triamcinolone acetonide (TA) in pars plana vitrectomy (PPV).

Design

Multicenter prospective controlled clinical trial.

Methods

SETTING and STUDY POPULATION: the study population comprised 774 eyes from patients treated at eight Japanese hospitals, among which 391 eyes underwent TA-assisted PPV and 383 control eyes underwent conventional PPV. The patients were assigned to the two groups using a single-blind quasi-randomization approach within the participating clinical centers. INTERVENTION: intra-operative use of TA to aid visualization of the vitreous. MAIN OUTCOME MEASURES: changes of visual acuity, post-operative complications (including additional surgery), and adverse events occurring within 1 year of the operation were compared between the TA-PPV group and the conventional PPV group.

Results

The visual acuity improved over time, and no significant differences were found between the two groups (log-rank versus TA, P = 0.98 for improvement, P = 0.26 for deterioration). The logistic regression model also showed that the intra-operative use of TA was not a significant factor for the improvement of visual acuity [P = 0.91, odds ratio (OR) = 1.10, 95% confidence interval (95%CI) = 0.860–1.183)] after adjustments for age, gender, and diagnosis. Intra-operative TA was not a significant factor for the need for additional surgery (log-rank test P = 0.45, logistic regression test P = 0.35, OR = 1.23, 95%CI = 0.797–1.911]. No serious adverse events related to surgery were observed.

Conclusions

This 1-year follow-up study of a controlled clinical trial showed that TA-assisted PPV had neither a positive nor a negative effect on visual acuity, the incidence of additional surgeries, or adverse events compared with conventional PPV.

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Title: One-year results of a multicenter controlled clinical trial of triamcinolone in pars plana vitrectomy
Authors: Keita Yamakiri
Taiji Sakamoto
Yoshihiro Noda
Masaaki Nakahara
Nobuchika Ogino
Toshiaki Kubota
Mitsunobu Yokoyama
Mariko Furukawa
Tatsuro Ishibashi
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0829-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

One-year results of a multicenter controlled clinical trial of triamcinolone in pars plana vitrectomy

Abstract

Purpose

Design

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Design

Methods

Results

Conclusions

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