Top

Published in:

Open Access 01-02-2021 | Constipation | Original Communication

The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Authors: Marina Picillo, Raffaele Palladino, Roberto Erro, Rossella Alfano, Carlo Colosimo, Roberto Marconi, Angelo Antonini, Paolo Barone, on behalf of the PRIAMO study group

Published in: Journal of Neurology | Issue 2/2021

Abstract

Objectives

To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages.

Methods

A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).

Results

As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.

Conclusions

Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

Available only for authorised users

Heizel S, Berg D, Gasser T, Chen H, Yao C, Postuma RB, MDS Task Force on the Definition of Parkinson’s Disease (2019) Update of the MDS Research criteria for prodromal Parkinson’s disease. Mov Disord 34:1464–1470CrossRef

Pilotto A, Heinzel S, Suenkel U, Lerche S, Brockmann K, Roeben B, Schaeffer E, Wurster I, Yilmaz R, Liepelt-Scarfone I, von Thaler AK, Metzger FG, Eschweiler GW, Postuma RB, Maetzler W, Berg D (2017) Application of the Movement Disorder Society prodromal Parkinson’s disease research criteria in 2 independent prospective cohorts. Mov Disord 32(7):1025–1034CrossRef

Schrag A, Anastasiou Z, Ambler G, Noyce A, Walters K (2020) Predicting diagnosis of Parkinson’s disease: a risk algorithm based on primary care presentations. Mov Disord 34(2):480–486

Heinzel S, Kasten M, Behnke S, Vollstedt EJ, Klein C, Hagenah J, Pausch C, Heilmann R, Brockmann K, Suenkel U, Yilmaz R, Liepelt-Scarfone I, Walter U, Berg D (2018) Age- and sex-related heterogeneity in prodromal Parkinson’s disease. Mov Disord 33(6):1025–1027CrossRef

Cottone C, Tosetti C, Disclafani G, Ubaldi E, Cogliandro R, Stanghellini V (2014) Clinical features of constipation in general practice in Italy. United Eur Gatroenterol J 2(3):232–238CrossRef

Yu Q, Yu S, Zuo L, Lian T, Hu Y, Wang R, Piano Y, Guo P, Liu L, Jin Z, Li L, Chan P, Chen S, Wang X, Zhang W (2018) Parkinson disease with constipation: clinical features and relevant factors. Sci Rep 8(1):567CrossRef

Martinez-Martin P, Pecurariu CF, Odin P, van Hilten J, Antonini A, Rojo-Abuin JM, Borges V, Trenkwalder C, Aarsland D, Brooks DJ, Chaudhuri KR (2012) Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease. J Neurol 259(8):1639–1647CrossRef

Stokholm MG, Danielsen EH, Hamilton-Dutoit SJ, Borghammer P (2016) Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients. Ann Neurol 79:940–949CrossRef

Breen DP, Halliday GM, Lang AE (2019) Gut–brain axis and the spread of α-synuclein pathology: vagal highway or dead end? Mov Disord 34:307–316CrossRef

10.

Antonini A, Colosimo C, Marconi R, Morgante L, Barone P, PRIAMO study group (2008) The PRIAMO study: background, methods and recruitment. Neurol Sci 29(2):61–65CrossRef

11.

Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, Bottacchi E, Cannas A, Ceravolo G, Ceravolo R, Cicarelli G, Gaglio RM, Giglia RM, Iemolo F, Manfredi M, Meco G, Nicoletti A, Pederzoli M, Petrone A, Pisani A, Pontieri FE, Quatrale R, Ramat S, Scala R, Volpe G, Zappulla S, Bentivoglio AR, Stocchi F, Trianni G, Dotto PD, PRIAMO study group (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24:1641–1649CrossRef

12.

Antonini A, Barone P, Marconi R, Morgante L, Zappulla S, Pontieri FE, Ramat S, Ceravolo MG, Meco G, Cicarelli G, Pederzoli M, Manfredi M, Ceravolo R, Mucchiut M, Volpe G, Abbruzzese G, Bottacchi E, Bartolomei L, Ciacci G, Cannas A, Randisi MG, Petrone A, Baratti M, Toni V, Cossu G, Del Dotto P, Bentivoglio AR, Abrignani M, Scala R, Pennisi F, Quatrale R, Gaglio RM, Nicoletti A, Perini M, Avarello T, Pisani A, Scaglioni A, Martinelli PE, Iemolo F, Ferigo L, Simone P, Soliveri P, Troianiello B, Consoli D, Mauro A, Lopiano L, Nastasi G, Colosimo C (2012) The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life. J Neurol 259(12):2621–2631CrossRef

13.

Picillo M, Palladino R, Barone P, Erro R, Colosimo C, Marconi R, Morgante L, Antonini A, PRIAMO Study Group (2017) The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson’s disease. Eur J Neurol 24:788–795CrossRef

14.

Picillo M, Palladino R, Erro R, Colosimo C, Marconi R, Antonini A, Barone P, PRIAMO study group (2019) The PRIAMO study: active sexual life is associated with better motor and non-motor outcomes in men with early Parkinson’s disease. Eur J Neurol 26(10):1327–1333CrossRef

15.

Savica R, Carlin JM, Grossardt BR, Bower JH, Ahlskog JE, Maraganore DM, Bharucha AE, Rocca WA (2009) Medical records documentation of constipation preceding Parkinson disease: a case-control study. Neurology 73(21):1752–1758CrossRef

16.

De Pablo-Fernandez E, Tur C, Revesz T, Lees AJ, Holton JL, Warner TT (2017) Association of autonomic dysfunction with disease progression and survival in Parkinson Disease. JAMA Neurol 74(8):970–976CrossRef

17.

Jones JD, Rahmani E, Garcia E, Jacobs JP (2020) Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson’s disease. Parkinson Relat Disord 72:7–12CrossRef

18.

Liping Z, Qiying S, Jifeng G, Xinxiang Y, Beisha T (2018) Study on the clinical features and related factors of constipation in patients with parkinson’s disease. J Chin Phys 20(1):6–8

19.

Sauerbier A, Jenner P, Todorova A, Chaudhuri KR (2016) Non motor subtypes and Parkinson’s disease. Parkinson Relat Disord 22:S41–46CrossRef

20.

Heinzel S, Aho VTE, Suenkel U, von Thaler AK, Schulte C, Deuschle C, Paulin L, Hantunen S, Brockmann K, Eschweiler GW, Maetzler W, Berg D, Auvinen P, Scheperjans F (2020) Gut microbiome signatures of risk and prodromal markers of Parkinson disease. Ann Neurol 00:1–12

21.

Verkujl SJ, Meinds RJ, Trzpis M, Broens PMA (2020) The influence of demographic characteristics on constipation symptoms: a detailed overview. BMC Gastroenterol 20:168CrossRef

Title: The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease
Authors: Marina Picillo
Raffaele Palladino
Roberto Erro
Rossella Alfano
Carlo Colosimo
Roberto Marconi
Angelo Antonini
Paolo Barone
on behalf of the PRIAMO study group
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Constipation
Parkinson's Disease
Constipation
Levodopa
Published in: Journal of Neurology / Issue 2/2021
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-10156-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 2/2021

Vestibular impairment in Charcot–Marie–Tooth disease

Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis

Specific B- and T-cell populations are associated with cognition in patients with epilepsy and antibody positive and negative suspected limbic encephalitis

Does pallidal neuromodulation influence cognitive decline in Huntington’s disease?

Deep brain stimulation of the internal globus pallidus does not affect the limbic circuit in patients with Parkinson’s disease: a PET study

Hemorrhagic reversible cerebral vasoconstriction syndrome: A retrospective observational study